Q8H0U5 · TIC62_ARATH
- ProteinProtein TIC 62, chloroplastic
- GeneTIC62
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids641 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in protein precursor import into chloroplasts. Part of the redox regulon consisting of TIC32, TIC 55 and TIC62 (PubMed:12426385).
Acts as a membrane anchor of LFNR1 and LFNR2. Has a NADPH-dependent dehydrogenase activity, but only after preincubation with lipids (By similarity).
Acts as a membrane anchor of LFNR1 and LFNR2. Has a NADPH-dependent dehydrogenase activity, but only after preincubation with lipids (By similarity).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 84-113 | NADP+ (UniProtKB | ChEBI) | |||
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chloroplast | |
Cellular Component | chloroplast envelope | |
Cellular Component | chloroplast inner membrane | |
Cellular Component | chloroplast stroma | |
Cellular Component | chloroplast thylakoid | |
Cellular Component | chloroplast thylakoid membrane | |
Cellular Component | chloroplast thylakoid membrane protein complex | |
Cellular Component | cytosol | |
Biological Process | protein transport |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameProtein TIC 62, chloroplastic
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ8H0U5
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Plastid, chloroplast inner membrane ; Peripheral membrane protein
Note: Shuttles between the membranes and the stroma, depending on the redox state of the plastidic NADP+/NADPH pool.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
No visible phenotype, but loss of membrane-bound LFNR1 or LFNR2.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 75 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for transit peptide, modified residue, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transit peptide | 1-63 | Chloroplast | |||
Modified residue | 64 | N-acetylalanine | |||
Chain | PRO_0000413675 | 64-641 | Protein TIC 62, chloroplastic | ||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in cotyledons and leaves, but not in roots.
Developmental stage
Expressed from day 3 of seedling development and continues throughout the development of photosynthetic tissues.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, repeat.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 328-641 | Disordered | |||
Compositional bias | 357-371 | Basic and acidic residues | |||
Repeat | 376-397 | 1 | |||
Region | 376-638 | 4 X 22 AA approximate repeats | |||
Compositional bias | 389-406 | Polar residues | |||
Compositional bias | 434-448 | Basic and acidic residues | |||
Repeat | 444-465 | 2 | |||
Compositional bias | 456-527 | Polar residues | |||
Repeat | 532-553 | 3 | |||
Compositional bias | 565-616 | Polar residues | |||
Repeat | 617-638 | 4 | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length641
- Mass (Da)68,342
- Last updated2003-03-01 v1
- ChecksumD99F4FB95A79833A
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 357-371 | Basic and acidic residues | |||
Compositional bias | 389-406 | Polar residues | |||
Compositional bias | 434-448 | Basic and acidic residues | |||
Compositional bias | 456-527 | Polar residues | |||
Compositional bias | 565-616 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP002039 EMBL· GenBank· DDBJ | BAB03098.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002686 EMBL· GenBank· DDBJ | AEE76164.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT002039 EMBL· GenBank· DDBJ | AAN72050.1 EMBL· GenBank· DDBJ | mRNA | ||
BT008403 EMBL· GenBank· DDBJ | AAP37762.1 EMBL· GenBank· DDBJ | mRNA |