Q8H0U5 · TIC62_ARATH

Function

function

Involved in protein precursor import into chloroplasts. Part of the redox regulon consisting of TIC32, TIC 55 and TIC62 (PubMed:12426385).
Acts as a membrane anchor of LFNR1 and LFNR2. Has a NADPH-dependent dehydrogenase activity, but only after preincubation with lipids (By similarity).

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site84-113NADP+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchloroplast
Cellular Componentchloroplast envelope
Cellular Componentchloroplast inner membrane
Cellular Componentchloroplast stroma
Cellular Componentchloroplast thylakoid
Cellular Componentchloroplast thylakoid membrane
Cellular Componentchloroplast thylakoid membrane protein complex
Cellular Componentcytosol
Biological Processprotein transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein TIC 62, chloroplastic
  • Alternative names
    • Translocon at the inner envelope membrane of chloroplasts 62
      (AtTIC62
      )

Gene names

    • Name
      TIC62
    • ORF names
      MCB22.6
    • Ordered locus names
      At3g18890

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q8H0U5
  • Secondary accessions
    • Q9LHN0

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype, but loss of membrane-bound LFNR1 or LFNR2.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 75 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for transit peptide, modified residue, chain.

Type
IDPosition(s)Description
Transit peptide1-63Chloroplast
Modified residue64N-acetylalanine
ChainPRO_000041367564-641Protein TIC 62, chloroplastic

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in cotyledons and leaves, but not in roots.

Developmental stage

Expressed from day 3 of seedling development and continues throughout the development of photosynthetic tissues.

Gene expression databases

Interaction

Subunit

Part of the Tic complex. Interacts with TIC110 and TIC55. Interacts with LFNR1 and LFNR2. Component of high molecular weight thylakoid LFNRs-containing protein complexes containing LIR1, LFNR1, LFNR2, TIC62 and TROL proteins.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, repeat.

Type
IDPosition(s)Description
Region328-641Disordered
Compositional bias357-371Basic and acidic residues
Repeat376-3971
Region376-6384 X 22 AA approximate repeats
Compositional bias389-406Polar residues
Compositional bias434-448Basic and acidic residues
Repeat444-4652
Compositional bias456-527Polar residues
Repeat532-5533
Compositional bias565-616Polar residues
Repeat617-6384

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    641
  • Mass (Da)
    68,342
  • Last updated
    2003-03-01 v1
  • Checksum
    D99F4FB95A79833A
MEGTCFLRGQPLTTIPSLPSRKGFLLQRWKTNRIVRFSGFKNHSVSGKSRSFDLSLRASGPIRASSVVTEASPTNLNSKEEDLVFVAGATGKVGSRTVRELLKLGFRVRAGVRSAQRAGSLVQSVKEMKLQNTDEGTQPVEKLEIVECDLEKKDSIQPALGNASVIICCIGASEKEISDITGPYRIDYLATKNLVDAATSAKVNNFILVTSLGTNKFGFPAAILNLFWGVLCWKRKAEEALIESGLNYAIVRPGGMERPTDAYKETHNLTLALDDTLFGGQVSNLQVAELLACMAKNPQLSFSKIVEVVAETTAPLTPIEKLLEKIPSKRPYVPPPKASVATKEVKPVPTKPVTQEPTAPKEDEAPPKEKNVKPRPLSPYASYEDLKPPTSPIPNSTTSVSPAKSKEVDATQVPVEANVVPVPDSTSNVPVVEVKQVEEKKERPLSPYARYENLKPPSSPSPTASSTRKSDSLSPGPTDSDTDKSSTVAKTVTETAVATSVTETSVATSVPETAVATSVTETAAPATSKMRPLSPYAIYADLKPPTSPTPASTGPKEAASVEDNSELPGGNNDVLKTVDGNLNTIPPSTPEAVPVVSSAIDTSLASGDNTAQPKPRPLSPYTMYADMKPPTSPLPSPVTNH

Sequence caution

The sequence BAB03098.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias357-371Basic and acidic residues
Compositional bias389-406Polar residues
Compositional bias434-448Basic and acidic residues
Compositional bias456-527Polar residues
Compositional bias565-616Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP002039
EMBL· GenBank· DDBJ
BAB03098.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002686
EMBL· GenBank· DDBJ
AEE76164.1
EMBL· GenBank· DDBJ
Genomic DNA
BT002039
EMBL· GenBank· DDBJ
AAN72050.1
EMBL· GenBank· DDBJ
mRNA
BT008403
EMBL· GenBank· DDBJ
AAP37762.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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