Q8GYY7 · DHU1_ARATH
- ProteinProtein DWD HYPERSENSITIVE TO UV-B 1
- GeneDHU1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids783 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
May act as a substrate receptor of a CUL4-RING E3 ubiquitin-protein ligase (CRL4) complex involved in the negative regulation of cellular responses to ultraviolet-B (UV-B) illumination, likely in coordination with RUP1 (PubMed:25193399, PubMed:28735869).
Interacts with COP1 and probably prevents the formation of active UVR8-COP1 complex, thus avoiding UVR8-COP1-mediated positive regulation of UV-B responses (PubMed:28735869).
Interacts with COP1 and probably prevents the formation of active UVR8-COP1 complex, thus avoiding UVR8-COP1-mediated positive regulation of UV-B responses (PubMed:28735869).
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | Cul4-RING E3 ubiquitin ligase complex | |
Cellular Component | nucleus | |
Biological Process | cellular response to UV-B | |
Biological Process | response to UV-B |
Names & Taxonomy
Protein names
- Recommended nameProtein DWD HYPERSENSITIVE TO UV-B 1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ8GYY7
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Hypersensitivity to ultraviolet-B (UV-B) illumination leading to short hypocotyls under UV-B; the sensitivity to UV-B is alleviated by the disruption of UVR8 and requires the presence of COP1 and HY5 (PubMed:25193399, PubMed:28735869).
The double mutants dhu1-1 cop1-6 and dhu1-1 hy5-215 phenotypes resemble that of single mutants cop1-6 and hy5-215, respectively (PubMed:28735869).
The UV-B responsiveness of the double mutant dhu1-1 rup1-1 is similar to that of the single mutants dhu1-1 and rup1-1 (PubMed:28735869).
The double mutants dhu1-1 cop1-6 and dhu1-1 hy5-215 phenotypes resemble that of single mutants cop1-6 and hy5-215, respectively (PubMed:28735869).
The UV-B responsiveness of the double mutant dhu1-1 rup1-1 is similar to that of the single mutants dhu1-1 and rup1-1 (PubMed:28735869).
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 24 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000454923 | 1-783 | Protein DWD HYPERSENSITIVE TO UV-B 1 | ||
Proteomic databases
PTM databases
Expression
Induction
Accumulates in response to ultraviolet-B (UV-B) illumination.
Gene expression databases
Structure
Family & Domains
Features
Showing features for repeat, motif.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Repeat | 145-198 | WD 1 | |||
Repeat | 212-256 | WD 2 | |||
Motif | 382-389 | Nuclear localization signal | |||
Repeat | 439-480 | WD 3 | |||
Repeat | 485-525 | WD 4 | |||
Repeat | 538-577 | WD 5 | |||
Repeat | 581-621 | WD 6 | |||
Repeat | 625-664 | WD 7 | |||
Repeat | 666-710 | WD 8 | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length783
- Mass (Da)88,171
- Last updated2003-03-01 v1
- Checksum1BBB2B4F937F87BF
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL035521 EMBL· GenBank· DDBJ | CAB36705.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AL161585 EMBL· GenBank· DDBJ | CAB80145.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002687 EMBL· GenBank· DDBJ | AEE86354.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK117309 EMBL· GenBank· DDBJ | BAC41980.1 EMBL· GenBank· DDBJ | mRNA | ||
BT005961 EMBL· GenBank· DDBJ | AAO64896.1 EMBL· GenBank· DDBJ | mRNA |