Q8GYY7 · DHU1_ARATH

Function

function

May act as a substrate receptor of a CUL4-RING E3 ubiquitin-protein ligase (CRL4) complex involved in the negative regulation of cellular responses to ultraviolet-B (UV-B) illumination, likely in coordination with RUP1 (PubMed:25193399, PubMed:28735869).
Interacts with COP1 and probably prevents the formation of active UVR8-COP1 complex, thus avoiding UVR8-COP1-mediated positive regulation of UV-B responses (PubMed:28735869).

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCul4-RING E3 ubiquitin ligase complex
Cellular Componentnucleus
Biological Processcellular response to UV-B
Biological Processresponse to UV-B

Names & Taxonomy

Protein names

  • Recommended name
    Protein DWD HYPERSENSITIVE TO UV-B 1

Gene names

    • Name
      DHU1
    • ORF names
      F10M10.50
      , F10M10_50
    • Ordered locus names
      At4g34280

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q8GYY7
  • Secondary accessions
    • Q9SYZ3

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Hypersensitivity to ultraviolet-B (UV-B) illumination leading to short hypocotyls under UV-B; the sensitivity to UV-B is alleviated by the disruption of UVR8 and requires the presence of COP1 and HY5 (PubMed:25193399, PubMed:28735869).
The double mutants dhu1-1 cop1-6 and dhu1-1 hy5-215 phenotypes resemble that of single mutants cop1-6 and hy5-215, respectively (PubMed:28735869).
The UV-B responsiveness of the double mutant dhu1-1 rup1-1 is similar to that of the single mutants dhu1-1 and rup1-1 (PubMed:28735869).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 24 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004549231-783Protein DWD HYPERSENSITIVE TO UV-B 1

Proteomic databases

PTM databases

Expression

Induction

Accumulates in response to ultraviolet-B (UV-B) illumination.

Gene expression databases

Interaction

Subunit

Interacts directly with DDB1A (PubMed:25193399).
Binds to COP1 and RUP1 (PubMed:28735869).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for repeat, motif.

Type
IDPosition(s)Description
Repeat145-198WD 1
Repeat212-256WD 2
Motif382-389Nuclear localization signal
Repeat439-480WD 3
Repeat485-525WD 4
Repeat538-577WD 5
Repeat581-621WD 6
Repeat625-664WD 7
Repeat666-710WD 8

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    783
  • Mass (Da)
    88,171
  • Last updated
    2003-03-01 v1
  • Checksum
    1BBB2B4F937F87BF
MATLTEIATLEEKYIELCKMHGILPNTAILSAFFEAEVKKSRNQRCIMNLYVDRVKYDDYLPLLELCNEINTSEVQGIDLFVRSACSLEDHYALPLIRSVNQKLRVVHLHDSFGKNFWQDVFFQGLSCKVLNVRSMHIHKLNIVGEFTQLHTLILDKNRIVGFGEDCFSCMPKLTYLSMCDTLVSDLWTSAAALLKLPSLKELRFQIWISCSDSSPLNSESSPSSSTKDDINTFIESDPPVEADMWDVAEQMDPSLPVEETLHSMDFSYKIPEQDDLDSHVSVSAGLNGEVLMREKVRRGKMPYQPKDVSPVDTFTRQFGNVGLKYISSKASPICSEKHYRMYMINSLPKLQVLDNLAIRKSDRDKAIETYSANFEDLPYKRKKESVVRVLENREKRSSKGKSQNSYKRSLCAAKMGSPASPLLHSLPFLSSRIQQEDDNSRLCPRQFEYHPLDPSLMVFGTLDGEVVVLNHESGKIFRYIPSNGSQSTILGLCWLKIYPSMVIAGSANGSLKLYDIQKASSTVTTSSHSTSGSVTFDEFDQLTSVHANSTDQLFLASGYSKDVALYDIGRGTRLQVFANMHQEHINVVKFSNHSPFLFATSSFDKDVKLWDLRQEPSRPCYTASSTKGNVMVCFSPDDRYLLASAVDNEVRQLLTVDGRLHLNFEIVPRVSSMNYTRSYYMNGNDYIISGSCDENVIRVCCAQTGRRLRDVTLEGNGSDFSMMYVQSLRGDPFRDFNMSVLAAYARSSSLSEIVKVNLLASRDSTAEESHGLRSYPSSSMGG

Sequence caution

The sequence CAB36705.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence CAB80145.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL035521
EMBL· GenBank· DDBJ
CAB36705.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AL161585
EMBL· GenBank· DDBJ
CAB80145.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002687
EMBL· GenBank· DDBJ
AEE86354.1
EMBL· GenBank· DDBJ
Genomic DNA
AK117309
EMBL· GenBank· DDBJ
BAC41980.1
EMBL· GenBank· DDBJ
mRNA
BT005961
EMBL· GenBank· DDBJ
AAO64896.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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