Q8GXX0 · ERV1_ARATH

Function

function

FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation (PubMed:14996837, PubMed:16893552).
Oxidizes thioredoxin in vitro (PubMed:14996837, PubMed:16893552).
Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space, and can act independently of the oxidoreductase MIA40 (PubMed:29117860, PubMed:38001802).
Can oxidize the cytochrome c oxidase assembly protein COX19, a typical substrate of MIA40 (PubMed:38001802).

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site76FAD (UniProtKB | ChEBI)
Binding site81FAD (UniProtKB | ChEBI)
Binding site84FAD (UniProtKB | ChEBI)
Binding site121FAD (UniProtKB | ChEBI)
Binding site125FAD (UniProtKB | ChEBI)
Binding site148FAD (UniProtKB | ChEBI)
Binding site151FAD (UniProtKB | ChEBI)
Binding site152FAD (UniProtKB | ChEBI)
Binding site155FAD (UniProtKB | ChEBI)
Binding site160FAD (UniProtKB | ChEBI)
Binding site171FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionflavin-dependent sulfhydryl oxidase activity
Molecular Functionidentical protein binding
Molecular Functionthiol oxidase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    FAD-linked sulfhydryl oxidase ERV1
  • EC number
  • Short names
    AtErv1
  • Alternative names
    • Mitochondrial sulfhydryl oxidase ERV1

Gene names

    • Name
      ERV1
    • ORF names
      F10F5.3
    • Ordered locus names
      At1g49880

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q8GXX0
  • Secondary accessions
    • Q8LC15
    • Q9C6C6

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Embryonic lethality when homozygous.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis177Loss the capacity to oxidize thioredoxin; when associated with A-182.
Mutagenesis182Loss the capacity to oxidize thioredoxin; when associated with A-177.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 16 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00004013771-191FAD-linked sulfhydryl oxidase ERV1
Disulfide bond119↔122Redox-active
Disulfide bond148↔165
Disulfide bond177↔182

Post-translational modification

Contains three disulfide bonds; one catalytic disulfide (Cys-119 to Cys-122), one structural disulfide (Cys-148 to Cys-165), and one shuttle disulfide (Cys-177 to Cys-182).

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, motif.

TypeIDPosition(s)Description
Domain72-172ERV/ALR sulfhydryl oxidase
Motif177-182Required for dimerization and substrate specificity

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    191
  • Mass (Da)
    21,600
  • Last updated
    2003-03-01 v1
  • Checksum
    7CC7FEA44C0D4B38
MGEKPWQPLLQSFEKLSNCVQTHLSNFIGIKNTPPSSQSTIQNPIISLDSSPPIATNSSSLQKLPLKDKSTGPVTKEDLGRATWTFLHTLAAQYPEKPTRQQKKDVKELMTILSRMYPCRECADHFKEILRSNPAQAGSQEEFSQWLCHVHNTVNRSLGKLVFPCERVDARWGKLECEQKSCDLHGTSMDF

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1P8AP23A0A1P8AP23_ARATHERV1157

Sequence caution

The sequence AAG51780.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict35-36in Ref. 6; AAM63908

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ551263
EMBL· GenBank· DDBJ
CAD83013.1
EMBL· GenBank· DDBJ
mRNA
AC079674
EMBL· GenBank· DDBJ
AAG51780.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002684
EMBL· GenBank· DDBJ
AEE32487.1
EMBL· GenBank· DDBJ
Genomic DNA
AK117991
EMBL· GenBank· DDBJ
BAC42626.1
EMBL· GenBank· DDBJ
mRNA
BT003718
EMBL· GenBank· DDBJ
AAO39946.1
EMBL· GenBank· DDBJ
mRNA
AY086861
EMBL· GenBank· DDBJ
AAM63908.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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