Q8GXV5 · UGHY_ARATH

Function

function

Involved in the catabolism of purine nucleotides. Can use (S)-2-ureidoglycine as substrate, but not allantoate. The sequential activity of AAH, UGLYAH and UAH allows a complete purine breakdown without the intermediate generation of urea.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
1.77 mM(S)-2-ureidoglycine
kcat is 761 sec-1 for (S)-2-ureidoglycine.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site235Mn2+ (UniProtKB | ChEBI)
Binding site235substrate
Binding site237Mn2+ (UniProtKB | ChEBI)
Binding site241Mn2+ (UniProtKB | ChEBI)
Binding site275Mn2+ (UniProtKB | ChEBI)
Binding site275substrate
Binding site287substrate
Binding site291substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionmetal ion binding
Molecular Functionureidoglycine aminohydrolase activity
Biological Processallantoin catabolic process
Biological Processpurine nucleobase catabolic process
Biological Processregulation of DNA-templated transcription
Biological Processureide catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    (S)-ureidoglycine aminohydrolase
  • EC number
  • Short names
    AtUGLYAH

Gene names

    • Name
      UGLYAH
    • Synonyms
      UGHY, YlbA
    • ORF names
      dl4555w, FCAALL.343
    • Ordered locus names
      At4g17050

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q8GXV5
  • Secondary accessions
    • O23549
    • Q67XN1
    • Q680J5

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis221Decreased activity.
Mutagenesis235Loss of manganese binding and loss of activity.
Mutagenesis235No effect on manganese binding, but loss of activity.
Mutagenesis237Loss of activity.
Mutagenesis241Loss of activity.
Mutagenesis252No effect on the affinity for the substrate, but decreased activity.
Mutagenesis275Loss of activity.
Mutagenesis287Loss of activity.
Mutagenesis291Loss of activity.
Mutagenesis291Increased affinity for the substrate, but decreased activity.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 65 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_000042344421-298(S)-ureidoglycine aminohydrolase

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homooctamer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain222-288Cupin type-2

Sequence similarities

Belongs to the UGHY family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    298
  • Mass (Da)
    33,673
  • Last updated
    2003-03-01 v1
  • Checksum
    50CED7DBA1C40A99
MRSLYLIVFIVISLVKASKSDDGFCSAPSIVESDEKTNPIYWKATNPTLSPSHLQDLPGFTRSVYKRDHALITPESHVYSPLPDWTNTLGAYLITPATGSHFVMYLAKMKEMSSSGLPPQDIERLIFVVEGAVTLTNTSSSSKKLTVDSYAYLPPNFHHSLDCVESATLVVFERRYEYLGSHTTELIVGSTDKQPLLETPGEVFELRKLLPMSVAYDFNIHTMDFQPGEFLNVKEVHYNQHGLLLLEGQGIYRLGDNWYPVQAGDVIWMAPFVPQWYAALGKTRSRYLLYKDVNRNPL

Sequence caution

The sequence CAB10485.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence CAB80976.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict138in Ref. 6; BAD44550
Sequence conflict224in Ref. 6; BAD43635

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GQ303359
EMBL· GenBank· DDBJ
ADH04164.1
EMBL· GenBank· DDBJ
mRNA
Z97342
EMBL· GenBank· DDBJ
CAB10485.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AL161545
EMBL· GenBank· DDBJ
CAB80976.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002687
EMBL· GenBank· DDBJ
AEE83843.1
EMBL· GenBank· DDBJ
Genomic DNA
AK118019
EMBL· GenBank· DDBJ
BAC42652.1
EMBL· GenBank· DDBJ
mRNA
AK176787
EMBL· GenBank· DDBJ
BAD44550.1
EMBL· GenBank· DDBJ
mRNA
AK175872
EMBL· GenBank· DDBJ
BAD43635.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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