Q8GUN5 · PHL1_ARATH
- ProteinProtein PHR1-LIKE 1
- GenePHL1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids413 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcription factor acting as central integrator of phosphate starvation responses (PubMed:20838596).
Regulates FER1 expression upon phosphate starvation, linking iron and phosphate homeostasis (PubMed:23788639).
Regulates FER1 expression upon phosphate starvation, linking iron and phosphate homeostasis (PubMed:23788639).
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 259-284 | H-T-H motif | ||||
Sequence: PKAVLKLLNNPGLTIYHVKSHLQKYR |
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameProtein PHR1-LIKE 1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ8GUN5
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
No effect on phosphate starvation responsiveness, due to the redundancy with PHR1.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 41 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000418125 | 1-413 | Protein PHR1-LIKE 1 | |||
Sequence: MTLANDFGYSTAMSSSYSALHTSVEDRYHKLPNSFWVSSGQELMNNPVPCQSVSGGNSGGYLFPSSSGYCNVSAVLPHGRNLQNQPPVSTVPRDRLAMQDCPLIAQSSLINHHPQEFIDPLHEFFDFSDHVPVQNLQAESSGVRVDSSVELHKKSEWQDWADQLISVDDGSEPNWSELLGDSSSHNPNSEIPTPFLDVPRLDITANQQQQMVSSEDQLSGRNSSSSVATSKQRMRWTPELHEAFVEAVNQLGGSERATPKAVLKLLNNPGLTIYHVKSHLQKYRTARYKPETSEVTGEPQEKKMTSIEDIKSLDMKTSVEITQALRLQMEVQKRLHEQLEIQRSLQLQIEKQGRYLQMMFEKQQKIQDNKSSSSEASPKQCNGSFAEVEVGLETLTGDQNESASASRKRVRED |
Proteomic databases
Expression
Tissue specificity
Expressed in shoots and roots.
Induction
Not up-regulated by Pi starvation.
Gene expression databases
Interaction
Subunit
Homodimers and heterodimers (PubMed:20838596).
Interacts with MED25 (PubMed:21343311, PubMed:21536906).
Does not interact with PHL2 or PHL3 (PubMed:26586833).
Interacts with MED25 (PubMed:21343311, PubMed:21536906).
Does not interact with PHL2 or PHL3 (PubMed:26586833).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8GUN5-2 | MED25 Q7XYY2-1 | 2 | EBI-15924466, EBI-15924435 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 171-196 | Disordered | ||||
Sequence: SEPNWSELLGDSSSHNPNSEIPTPFL | ||||||
Compositional bias | 176-191 | Polar residues | ||||
Sequence: SELLGDSSSHNPNSEI | ||||||
Region | 208-233 | Disordered | ||||
Sequence: QQQMVSSEDQLSGRNSSSSVATSKQR | ||||||
Domain | 228-288 | HTH myb-type | ||||
Sequence: ATSKQRMRWTPELHEAFVEAVNQLGGSERATPKAVLKLLNNPGLTIYHVKSHLQKYRTARY | ||||||
Region | 322-342 | Coiled coil | ||||
Sequence: TQALRLQMEVQKRLHEQLEIQ | ||||||
Motif | 335-340 | LHEQLE | ||||
Sequence: LHEQLE | ||||||
Compositional bias | 363-381 | Polar residues | ||||
Sequence: QQKIQDNKSSSSEASPKQC | ||||||
Region | 363-413 | Disordered | ||||
Sequence: QQKIQDNKSSSSEASPKQCNGSFAEVEVGLETLTGDQNESASASRKRVRED |
Sequence similarities
Belongs to the MYB-CC family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q8GUN5-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length413
- Mass (Da)46,221
- Last updated2003-03-01 v1
- Checksum739BAB69CD76C047
Q8GUN5-2
- Name2
- Differences from canonical
- 1-43: Missing
Q8GUN5-3
- Name3
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_043994 | 1-43 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 26 | in Ref. 4; AAM61707 | ||||
Sequence: D → H | ||||||
Compositional bias | 176-191 | Polar residues | ||||
Sequence: SELLGDSSSHNPNSEI | ||||||
Alternative sequence | VSP_043995 | 298-311 | in isoform 3 | |||
Sequence: EPQEKKMTSIEDIK → KELKYFNIILLHFF | ||||||
Alternative sequence | VSP_043996 | 312-413 | in isoform 3 | |||
Sequence: Missing | ||||||
Compositional bias | 363-381 | Polar residues | ||||
Sequence: QQKIQDNKSSSSEASPKQC |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC018632 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CP002688 EMBL· GenBank· DDBJ | AED93856.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED93857.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED93858.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED93859.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT002344 EMBL· GenBank· DDBJ | AAN86177.1 EMBL· GenBank· DDBJ | mRNA | ||
AY085154 EMBL· GenBank· DDBJ | AAM61707.1 EMBL· GenBank· DDBJ | mRNA |