Q8GS71 · KN4A_ARATH
- ProteinKinesin-like protein KIN-4A
- GeneKIN4A
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1035 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Kinesin-like motor protein involved in the control of the oriented deposition of cellulose microfibrils (PubMed:12468730, Ref.6). Its motor activity is directed toward the microtubule's plus end. It possesses the potential to drive long-distance transport of cargo along cortical microtubules (PubMed:21914648, PubMed:25646318).
Regulates cell wall mechanics during cell elongation, by the regulation of primary and secondary walls deposition (PubMed:25600279, PubMed:25646318, Ref.6). Contributes to cortical microtubule-mediated trafficking of cell wall components (PubMed:25646318).
Regulates cell wall mechanics during cell elongation, by the regulation of primary and secondary walls deposition (PubMed:25600279, PubMed:25646318, Ref.6). Contributes to cortical microtubule-mediated trafficking of cell wall components (PubMed:25646318).
Miscellaneous
Overexpression of KIN4A/FRA1 caused a severe reduction in the thickness of secondary walls in interfascicular fibers and deformation of vessels, an increase in the number of secondary wall layers, which are accompanied with a marked decrease in stem strength.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cortical microtubule | |
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | microtubule binding | |
Molecular Function | microtubule motor activity | |
Molecular Function | plus-end-directed microtubule motor activity | |
Molecular Function | sequence-specific DNA binding | |
Biological Process | cellulose microfibril organization | |
Biological Process | cytoskeleton-dependent intracellular transport | |
Biological Process | microtubule-based movement | |
Biological Process | plant-type cell wall biogenesis | |
Biological Process | positive regulation of DNA-templated transcription | |
Biological Process | regulation of cell population proliferation | |
Biological Process | regulation of gibberellic acid mediated signaling pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameKinesin-like protein KIN-4A
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ8GS71
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Concentrated around the periphery of the cytoplasm.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Reduced length of roots and inflorescence stems. Altered orientation of cellulose microfibrils in fiber walls leading to dramatic reduction in fiber mechanical strength. No apparent alteration in cell wall composition. Lower expansion rate of the inflorescence stem along with the reduced thickness of both primary and secondary cell walls leading to mechanically weaker stems (PubMed:25646318).
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 53 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000431962 | 1-1035 | Kinesin-like protein KIN-4A | |||
Sequence: MESTPPPDDCSVKVAVHIRPLIGDERIQGCQDCVTVVTGKPQVQIGSHSFTFDHVYGSSGSPSTEMYEECAAPLVDGLFQGYNATVLAYGQTGSGKTYTMGTGCGDSSQTGIIPQVMNALFTKIETLKQQIEFQIHVSFIEIHKEEVQDLLDPCTVNKSDTNNTGHVGKVAHVPGKPPIQIRETSNGVITLAGSTEVSVSTLKEMAACLDQGSVSRATGSTNMNNQSSRSHAIFTITVEQMRKINTDSPENGAYNGSLKEEYLCAKLHLVDLAGSERAKRTGSDGLRFKEGVHINKGLLALGNVISALGDEKKRKDGAHVPYRDSKLTRLLQDSLGGNSRTVMIACISPADINAEETLNTLKYANRARNIRNKPVVNRDPVSSEMLKMRQQVEYLQAELSLRTGGSSCAEVQALKERIVWLETANEELCRELHEYRSRCPGVEHSEKDFKDIRADDIVGSVRPDGLKRSLHSIESSNYPMVEATTGDSREIDEEAKEWEHKLLQNSMDKELYELNRRLEEKESEMKLFDGYDPAALKQHFGKKIAEVEDEKRSVQEERNRLLAEIENLASDGQAQKLQDVHAQNLKALEAQILDLKKKQESQVQLLKQKQKSDDAARRLQDEIQSIKAQKVQLQHRMKQEAEQFRQWKASREKELLQLRKEGRKSEYERHKLQALNQRQKMVLQRKTEEAAMATKRLKELLEARKSSPREHSAGTNGFGTNGQTNEKSLQRWLDHELEVMVNVHEVRHEYEKQSHVRAALAEELAVLRQVDEFAVKGLSPPRGKNGFARASSLSPNARMARISSLENMLVISSNSLVAMASQLSEAEERERAFTNRGRWNQLRSMGEAKNLLQYMFNSLAETRCQLWEKDVEIKEMKDQFKEIVGLLRQSELRRKEAEKELKLREQAIATSLGTPPSSVKHVAEDLSTPSPMTVPAQKQLKFTPGIANGKVRGPAAFLDTNKKMVPMGQVSMRKLSAVGKQGGRLWRWKRSHHQWIVQFKWKWQKPWRLSEWIRTSDETLLKSKPRLKALPNKIM |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in stems and flowers (PubMed:12468730).
Detected in cells undergoing secondary wall deposition including developing interfascicular fibers and xylem cells, but also in dividing cells and expanding/elongating parenchyma cells (Ref.6)
Detected in cells undergoing secondary wall deposition including developing interfascicular fibers and xylem cells, but also in dividing cells and expanding/elongating parenchyma cells (Ref.6)
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for domain, coiled coil, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 11-370 | Kinesin motor | ||||
Sequence: SVKVAVHIRPLIGDERIQGCQDCVTVVTGKPQVQIGSHSFTFDHVYGSSGSPSTEMYEECAAPLVDGLFQGYNATVLAYGQTGSGKTYTMGTGCGDSSQTGIIPQVMNALFTKIETLKQQIEFQIHVSFIEIHKEEVQDLLDPCTVNKSDTNNTGHVGKVAHVPGKPPIQIRETSNGVITLAGSTEVSVSTLKEMAACLDQGSVSRATGSTNMNNQSSRSHAIFTITVEQMRKINTDSPENGAYNGSLKEEYLCAKLHLVDLAGSERAKRTGSDGLRFKEGVHINKGLLALGNVISALGDEKKRKDGAHVPYRDSKLTRLLQDSLGGNSRTVMIACISPADINAEETLNTLKYANRARNI | ||||||
Coiled coil | 408-436 | |||||
Sequence: CAEVQALKERIVWLETANEELCRELHEYR | ||||||
Coiled coil | 504-707 | |||||
Sequence: QNSMDKELYELNRRLEEKESEMKLFDGYDPAALKQHFGKKIAEVEDEKRSVQEERNRLLAEIENLASDGQAQKLQDVHAQNLKALEAQILDLKKKQESQVQLLKQKQKSDDAARRLQDEIQSIKAQKVQLQHRMKQEAEQFRQWKASREKELLQLRKEGRKSEYERHKLQALNQRQKMVLQRKTEEAAMATKRLKELLEARKSS | ||||||
Region | 704-724 | Disordered | ||||
Sequence: RKSSPREHSAGTNGFGTNGQT | ||||||
Compositional bias | 710-724 | Polar residues | ||||
Sequence: EHSAGTNGFGTNGQT | ||||||
Coiled coil | 881-911 | |||||
Sequence: KEIVGLLRQSELRRKEAEKELKLREQAIATS |
Domain
Composed of an N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule) and a central to C-terminal alpha-helical coiled coil domain that mediates the heavy chain dimerization.
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,035
- Mass (Da)116,734
- Last updated2003-03-01 v1
- Checksum6DF0B4C16B88588C
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 710-724 | Polar residues | ||||
Sequence: EHSAGTNGFGTNGQT |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY158083 EMBL· GenBank· DDBJ | AAN86114.1 EMBL· GenBank· DDBJ | mRNA | ||
AY158084 EMBL· GenBank· DDBJ | AAN86115.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB016886 EMBL· GenBank· DDBJ | BAB11329.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002688 EMBL· GenBank· DDBJ | AED95575.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED95576.1 EMBL· GenBank· DDBJ | Genomic DNA |