Q8FA29 · Q8FA29_LEPIN

Function

function

Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site17-19FMN (UniProtKB | ChEBI)
Binding site71FMN (UniProtKB | ChEBI)
Active site101Proton donor
Binding site140FMN (UniProtKB | ChEBI)
Binding site170FMN (UniProtKB | ChEBI)
Binding site225-226FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionRNA binding
Molecular FunctiontRNA dihydrouridine synthase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA-dihydrouridine synthase
  • EC number

Gene names

    • Ordered locus names
      LA_0007

Organism names

Accessions

  • Primary accession
    Q8FA29

Proteomes

PTM/Processing

Proteomic databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-302DUS-like FMN-binding

Sequence similarities

Belongs to the dus family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    329
  • Mass (Da)
    37,543
  • Last updated
    2003-03-01 v1
  • Checksum
    C2DA18B33B5EBFF5
MIRIGNVTIPGKISLSPMAGISDSPTRRICRKFGAAFSYTEFVNTDELVHRAPKALKMFRYKSEERPITFQIFGNRLEIIAEAAEIIQELKPDIIDLNMGCSTRKVSLRGAGAGLLRRPLLAGKIIEAIKKRVNIPVTAKIRIGWDSTSRNYLEVSKILEESGVDALTVHGRTKEMAYTGFADWDAIGEIKVNRKIPIFGNGDIKSFQEANFKIDKYLLDGVLIGRNAIGNPWIFSGVKKEELSWSEVLDVILQHLRWMIEDYGEEFGLVLFRKHLVKYLNGLEFDLAWKTELLEIKEWNRFEDILLSDKKRIEFTVPTFGTTKRFVFP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE010300
EMBL· GenBank· DDBJ
AAN47206.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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