Q8F8T9 · RISB_LEPIN

Function

function

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

Catalytic activity

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.

Features

Showing features for binding site, active site.

115120406080100120140
TypeIDPosition(s)Description
Binding site235-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site55-575-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site79-815-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site84-85(2S)-2-hydroxy-3-oxobutyl phosphate (UniProtKB | ChEBI)
Active site87Proton donor
Binding site1115-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site125(2S)-2-hydroxy-3-oxobutyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentriboflavin synthase complex
Molecular Function6,7-dimethyl-8-ribityllumazine synthase activity
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    6,7-dimethyl-8-ribityllumazine synthase
  • EC number
  • Short names
    DMRL synthase
    ; LS
    ; Lumazine synthase

Gene names

    • Name
      ribH
    • Ordered locus names
      LA_0463

Organism names

Accessions

  • Primary accession
    Q8F8T9

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001347691-1516,7-dimethyl-8-ribityllumazine synthase

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the DMRL synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    151
  • Mass (Da)
    15,927
  • Last updated
    2003-03-01 v1
  • Checksum
    345E737782921F73
MIQELKADLNGKGQKHCVIVSRFNEFITESLLKGALESFRMHGVEDVTVVRVPGAYEMPMVVSKAAASKKYDSIVCLGAVIRGATAHFDLVAGESAKIGSIGVQHSIPVIFGVLTTDTIEQAIERAGTKAGNKGAEAAATAVEMVNLLSLL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE010300
EMBL· GenBank· DDBJ
AAN47662.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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