Q8F1X4 · LGT_LEPIN
- ProteinPhosphatidylglycerol--prolipoprotein diacylglyceryl transferase
- Genelgt
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids318 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
Catalytic activity
- 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H+ + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate
Pathway
Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity | |
Biological Process | lipoprotein biosynthetic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylglycerol--prolipoprotein diacylglyceryl transferase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Spirochaetota > Spirochaetia > Leptospirales > Leptospiraceae > Leptospira
Accessions
- Primary accessionQ8F1X4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 24-44 | Helical | ||||
Sequence: GPSTFSILMMIGFLTASYLLP | ||||||
Transmembrane | 60-80 | Helical | ||||
Sequence: LLLLGILGTLVGAKIFFVFEI | ||||||
Transmembrane | 115-135 | Helical | ||||
Sequence: LFSGSGLVFYGGFLFGILFIT | ||||||
Transmembrane | 198-218 | Helical | ||||
Sequence: VPVWNTPLIESIISFLFFFYF | ||||||
Transmembrane | 285-305 | Helical | ||||
Sequence: GFSQSQLVSIIIILVGAFFIL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000172625 | 1-318 | Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase | |||
Sequence: MIDRIPVPFLNPLFKFLFNREWDGPSTFSILMMIGFLTASYLLPKELKRRKLEPEHSDWLLLLGILGTLVGAKIFFVFEIWDQIFVETPGFDGKYIYPLTHWYGFPGRMSLWDNLFSGSGLVFYGGFLFGILFITLYMKYFQLDIASYLDAAVPSMAIGYAIGRLGCWVSGDGCYGFATNVEIPLLVFNYHGAHPSGVPVWNTPLIESIISFLFFFYFQFWARNQNFKKFSIGAQYLVLHGFARLLVEFLRVNKAVFPLMDPPAFVNIPNAEQNPEFLTQYYWHGFSQSQLVSIIIILVGAFFILKWKLWKKENTSNI |
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Belongs to the Lgt family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length318
- Mass (Da)36,708
- Last updated2003-03-01 v1
- ChecksumCBA13EC656B85D39
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE010300 EMBL· GenBank· DDBJ | AAN50202.1 EMBL· GenBank· DDBJ | Genomic DNA |