Q8F150 · TRPA_LEPIN
- ProteinTryptophan synthase alpha chain
- GenetrpA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids264 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
Catalytic activity
- (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan
Pathway
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 45 | Proton acceptor | ||||
Sequence: E | ||||||
Active site | 56 | Proton acceptor | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | tryptophan synthase activity | |
Biological Process | tryptophan biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTryptophan synthase alpha chain
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Spirochaetota > Spirochaetia > Leptospirales > Leptospiraceae > Leptospira
Accessions
- Primary accessionQ8F150
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000098802 | 1-264 | Tryptophan synthase alpha chain | |||
Sequence: MNSISSVFSSEQSVFIPYISLGDPDYDSCVIWADALIRGGAGILELGIPFTDPVADGPVIQKAFKRSLAHPFSMDKILEVTSEIHKLHPQIPLVYLTYFNPLFSMGLESFTERAKNSGIQGLIIPDLPFDTPEAEEFFSQLERKRIDFIHLVTPATTEDRIRSMKSLASGFIYYVTSYGVTGERGSIASGLEDRIRMVRKIVGLPVCAGFGISTSDQSKVISTYADGVIIGSAVQRIIEENGSDRNNCADKLLAYASEIRASMR |
Proteomic databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length264
- Mass (Da)29,028
- Last updated2003-03-01 v1
- Checksum4CE0FDD6F1C87335
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE010300 EMBL· GenBank· DDBJ | AAN50486.1 EMBL· GenBank· DDBJ | Genomic DNA |