Q8E8N6 · BIOH_SHEON
- ProteinPimeloyl-[acyl-carrier protein] methyl ester esterase
- GenebioH
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids263 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
Catalytic activity
- 6-carboxyhexanoyl-[ACP] methyl ester + H2O = 6-carboxyhexanoyl-[ACP] + H+ + methanol
Pathway
Cofactor biosynthesis; biotin biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 28 | substrate | ||||
Sequence: W | ||||||
Active site | 86 | Nucleophile | ||||
Sequence: S | ||||||
Binding site | 86-87 | substrate | ||||
Sequence: SL | ||||||
Binding site | 149-153 | substrate | ||||
Sequence: FLAIQ | ||||||
Active site | 213 | |||||
Sequence: D | ||||||
Active site | 240 | |||||
Sequence: H | ||||||
Binding site | 240 | substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | carboxylic ester hydrolase activity | |
Biological Process | biotin biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended namePimeloyl-[acyl-carrier protein] methyl ester esterase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Alteromonadales > Shewanellaceae > Shewanella
Accessions
- Primary accessionQ8E8N6
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000204493 | 1-263 | Pimeloyl-[acyl-carrier protein] methyl ester esterase | |||
Sequence: MNATTSAHHPLHIETIGQGPDLVVIHGWGVNSAVFTPLHEQLSEYRVHYVDLPGFGLSQPIAGNLSTWIDALINNLPTNAIWAGWSLGGLVATQAAIDYPSHIKGLITIASSPCFMAREEEAWPGIPPQVLSMFGEQLGQNLPKTIERFLAIQAMGSETAKEDIKQLRDLVLARPLPDAAALTQGLDMLNQIDLRMQLSSISQPWLRIWGRLDGLVPKRVQPQMPTASHITDVMLAKASHAPFVSHRQEFLQALLPWLTQFKD |
Proteomic databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length263
- Mass (Da)28,993
- Last updated2005-08-16 v2
- ChecksumB0B1B3522862233D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014299 EMBL· GenBank· DDBJ | AAN57586.2 EMBL· GenBank· DDBJ | Genomic DNA |