Q8E6L0 · PYRDA_STRA3
- ProteinPutative dihydroorotate dehydrogenase A (fumarate)
- GenepyrD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids310 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.
Catalytic activity
- (S)-dihydroorotate + fumarate = orotate + succinate
Cofactor
Note: Binds 1 FMN per subunit.
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 45 | substrate | |||
Binding site | 45-46 | FMN (UniProtKB | ChEBI) | |||
Binding site | 69-73 | substrate | |||
Binding site | 128 | FMN (UniProtKB | ChEBI) | |||
Binding site | 128 | substrate | |||
Active site | 131 | Nucleophile | |||
Binding site | 165 | FMN (UniProtKB | ChEBI) | |||
Binding site | 193 | FMN (UniProtKB | ChEBI) | |||
Binding site | 194-195 | substrate | |||
Binding site | 220 | FMN (UniProtKB | ChEBI) | |||
Binding site | 248-249 | FMN (UniProtKB | ChEBI) | |||
Binding site | 270-271 | FMN (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | dihydroorotate dehydrogenase (fumarate) activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePutative dihydroorotate dehydrogenase A (fumarate)
- EC number
- Short namesDHOD A; DHODase A; DHOdehase A
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillati > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus
Accessions
- Primary accessionQ8E6L0
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000100228 | 1-310 | Putative dihydroorotate dehydrogenase A (fumarate) | ||
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length310
- Mass (Da)34,257
- Last updated2003-03-01 v1
- MD5 Checksum1914CFDE84D9C82E3B2851C46B36C6B1
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL766846 EMBL· GenBank· DDBJ | CAD46197.1 EMBL· GenBank· DDBJ | Genomic DNA |