Q8DZQ2 · PYRF_STRA5
- ProteinOrotidine 5'-phosphate decarboxylase
- GenepyrF
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids233 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Catalytic activity
- orotidine 5'-phosphate + H+ = UMP + CO2
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 11 | substrate | |||
Binding site | 34 | substrate | |||
Binding site | 61-70 | substrate | |||
Active site | 63 | Proton donor | |||
Binding site | 117 | substrate | |||
Binding site | 179 | substrate | |||
Binding site | 189 | substrate | |||
Binding site | 209 | substrate | |||
Binding site | 210 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | orotidine-5'-phosphate decarboxylase activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOrotidine 5'-phosphate decarboxylase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus
Accessions
- Primary accessionQ8DZQ2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000134585 | 1-233 | Orotidine 5'-phosphate decarboxylase | ||
Interaction
Structure
Sequence
- Sequence statusComplete
- Length233
- Mass (Da)25,994
- Last updated2003-03-01 v1
- Checksum708384FCF55E472D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE009948 EMBL· GenBank· DDBJ | AAM99929.1 EMBL· GenBank· DDBJ | Genomic DNA |