Q8DQ50 · PYRH_STRR6
- ProteinUridylate kinase
- GenepyrH
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids247 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reversible phosphorylation of UMP to UDP.
Catalytic activity
- ATP + UMP = ADP + UDP
Activity regulation
Allosterically activated by GTP. Inhibited by UTP.
Pathway
Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 14-17 | ATP (UniProtKB | ChEBI) | ||||
Sequence: KLSG | ||||||
Binding site | 56 | UMP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 57 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 61 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 76 | UMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 137-144 | UMP (UniProtKB | ChEBI) | ||||
Sequence: IGSPYFST | ||||||
Binding site | 165 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 171 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 174 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | UMP kinase activity | |
Biological Process | 'de novo' CTP biosynthetic process | |
Biological Process | UDP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUridylate kinase
- EC number
- Short namesUK
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus
Accessions
- Primary accessionQ8DQ50
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000143893 | 1-247 | Uridylate kinase | |||
Sequence: MKMANPKYKRILIKLSGEALAGERGVGIDIQTVQTIAKEIQEVHSLGIEIALVIGGGNLWRGEPAAEAGMDRVQADYTGMLGTVMNALVMADSLQQVGVDTRVQTAIAMQQVAEPYVRGRALRHLEKGRIVIFGAGIGSPYFSTDTTAALRAAEIEADAILMAKNGVDGVYNADPKKDKTAVKFEELTHRDVINKGLRIMDSTASTLSMDNDIDLVVFNMNQSGNIKRVVFGENIGTTVSNNIEEKE |
Interaction
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 22-27 | Involved in allosteric activation by GTP | ||||
Sequence: GERGVG |
Sequence similarities
Belongs to the UMP kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length247
- Mass (Da)26,693
- Last updated2003-03-01 v1
- Checksum6DEF633ED4EBFFD4
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE007317 EMBL· GenBank· DDBJ | AAK99649.1 EMBL· GenBank· DDBJ | Genomic DNA |