Q8DKY0 · NU4C1_THEVB
- ProteinNAD(P)H-quinone oxidoreductase chain 4 1
- GenendhD1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids529 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic activity
- a plastoquinone + (n+1) H+(in) + NADH = a plastoquinol + n H+(out) + NAD+
a plastoquinone RHEA-COMP:9562 + (n+1) H+ (in)CHEBI:15378+ CHEBI:57945 = a plastoquinol RHEA-COMP:9561 + n H+ (out)CHEBI:15378+ CHEBI:57540 - a plastoquinone + (n+1) H+(in) + NADPH = a plastoquinol + n H+(out) + NADP+
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane-derived thylakoid membrane | |
Cellular Component | respiratory chain complex I | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Molecular Function | NADH dehydrogenase activity | |
Molecular Function | ubiquinone binding | |
Biological Process | ATP synthesis coupled electron transport | |
Biological Process | electron transport coupled proton transport |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameNAD(P)H-quinone oxidoreductase chain 4 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Acaryochloridales > Thermosynechococcaceae > Thermosynechococcus
Accessions
- Primary accessionQ8DKY0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cellular thylakoid membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 4-24 | Helical | ||||
Sequence: FPWLTTIILFPIVAALAIPFI | ||||||
Transmembrane | 36-56 | Helical | ||||
Sequence: WYALAVGLIDFALIVYAFTNF | ||||||
Transmembrane | 91-111 | Helical | ||||
Sequence: LILLTGFITTLAILAAWPVTL | ||||||
Transmembrane | 115-135 | Helical | ||||
Sequence: LFYFLMLAMYGGQIAVFAVQD | ||||||
Transmembrane | 137-157 | Helical | ||||
Sequence: LVFFLAWELELIPVYLLLAIW | ||||||
Transmembrane | 169-189 | Helical | ||||
Sequence: FILYTAGSSLFILVAGLAMAF | ||||||
Transmembrane | 209-229 | Helical | ||||
Sequence: GFQLLVYAGFLVAYGVKLPIV | ||||||
Transmembrane | 243-263 | Helical | ||||
Sequence: TAPVHMLLAGILLKMGGYALI | ||||||
Transmembrane | 277-297 | Helical | ||||
Sequence: FAPVLVILGVVNIIYAALTSY | ||||||
Transmembrane | 314-334 | Helical | ||||
Sequence: IGFVLIGIASFTNLGMSGAVL | ||||||
Transmembrane | 335-355 | Helical | ||||
Sequence: QMVSHGLIGASLFFLVGATYD | ||||||
Transmembrane | 387-407 | Helical | ||||
Sequence: LALPGMSGFVAELMVFIGFAT | ||||||
Transmembrane | 417-437 | Helical | ||||
Sequence: VIVVFLAAVGVILTPIYLLSM |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000343245 | 1-529 | NAD(P)H-quinone oxidoreductase chain 4 1 | |||
Sequence: MSTFPWLTTIILFPIVAALAIPFIPDPTGKGRPIRWYALAVGLIDFALIVYAFTNFYDLNTPGMQLWESYDWIPEIGLRWSVGADGLSMPLILLTGFITTLAILAAWPVTLKPRLFYFLMLAMYGGQIAVFAVQDMLVFFLAWELELIPVYLLLAIWGGHKRQYAATKFILYTAGSSLFILVAGLAMAFYGDTVSFDMQTLAAKDYALGFQLLVYAGFLVAYGVKLPIVPLHTWLPDAHGEATAPVHMLLAGILLKMGGYALIRMNVDMLPAAHAKFAPVLVILGVVNIIYAALTSYAQRNLKRKIAYSSISHIGFVLIGIASFTNLGMSGAVLQMVSHGLIGASLFFLVGATYDRTHTLILEEMGGVGQKMKKIFAMFTACSLASLALPGMSGFVAELMVFIGFATSDAYSLPFRVIVVFLAAVGVILTPIYLLSMLREIFYGPENKELVEHEALVDAEPREVFIIACLLVPIIGIGLYPKLLTQIYDATTGQVIARAREVLPTLAQQTEQPLGILPMVAPQLKANAQ |
Keywords
- PTM
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8DKY0 | ndhF1 Q8DKX9 | 2 | EBI-629650, EBI-629633 |
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length529
- Mass (Da)57,809
- Last updated2008-07-01 v2
- ChecksumD563D52DAAC8E11D
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BA000039 EMBL· GenBank· DDBJ | BAC08270.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation |