Q8DGC3 · NNR_THEVB

Function

function

Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity).

Catalytic activity

Cofactor

K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site64K+ (UniProtKB | ChEBI)
Binding site124K+ (UniProtKB | ChEBI)
Binding site157(6S)-NADPHX 1 (UniProtKB | ChEBI); for epimerase activity
Binding site160K+ (UniProtKB | ChEBI)
Binding site330(6S)-NADPHX 2 (UniProtKB | ChEBI); for dehydratase activity
Binding site412-416ADP (UniProtKB | ChEBI)
Binding site432-441ADP (UniProtKB | ChEBI)
Binding site442(6S)-NADPHX 2 (UniProtKB | ChEBI); for dehydratase activity

GO annotations

AspectTerm
Molecular FunctionADP-dependent NAD(P)H-hydrate dehydratase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular FunctionNADHX epimerase activity
Molecular FunctionNADPHX epimerase activity
Biological Processmetabolite repair
Biological Processnicotinamide nucleotide metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional NAD(P)H-hydrate repair enzyme Nnr
  • Alternative names
    • Nicotinamide nucleotide repair protein

Including 2 domains:

  • Recommended name
    ADP-dependent (S)-NAD(P)H-hydrate dehydratase
  • EC number
  • Alternative names
    • ADP-dependent NAD(P)HX dehydratase
  • Recommended name
    NAD(P)H-hydrate epimerase
  • EC number
  • Alternative names
    • NAD(P)HX epimerase

Gene names

    • Name
      nnr
    • Ordered locus names
      tll2395

Organism names

Accessions

  • Primary accession
    Q8DGC3

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004164231-505Bifunctional NAD(P)H-hydrate repair enzyme Nnr

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-219NAD(P)H-hydrate epimerase
Domain14-214YjeF N-terminal
Region63-67NADPHX 1; for epimerase activity
Region128-134NADPHX 1; for epimerase activity
Domain226-500YjeF C-terminal
Region227-505ADP-dependent (S)-NAD(P)H-hydrate dehydratase
Region376-382NADPHX 2; for dehydratase activity

Sequence similarities

In the N-terminal section; belongs to the NnrE/AIBP family.
In the C-terminal section; belongs to the NnrD/CARKD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    505
  • Mass (Da)
    53,934
  • Last updated
    2003-03-01 v1
  • Checksum
    503588EDBFF6BCF0
MKPTFPAIVTTAEMQAIEGAMFNGGLPIPALMEKVGQRLSHYLQAHFPTSQYPRVAVLAGPGHNGGDALVVARELWHRGYQVKLWQPFERLKPLTADHARYARFLGLPFVERVEALQEVDVIVDGLFGFGLERELTGELAHAIDEINTWPQPRVSIDVPSGLHSDTGAVLGTAIRADRTLCLGLWKRGLLVEEAQPWVGQGVLIPFDIPSVVIETALASAPRRYCLDDSCWQALPLSRSPITHKYQQGQLLLIGGSGQFGGSILLSALAARCTGVGMLVVAVPQSLKSLVLSRVPDAIVVGCPETPRGAIARLPEGLELGKFSAIACGPGLTPEAVSVVATVLRAETSLVLDADALNILATLSPWPLPSGTILTPHYGEFRRLFPDLVGTAGDRLDQVIAAARWSNAIVLLKGARTAIASARGDLWINPHSTPALARGGSGDVLTGLIGGLLAQQEALRATYGGVWWHAQAALEAEQQATSLGVYPEQLIAHLLPTLRRALAARV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000039
EMBL· GenBank· DDBJ
BAC09947.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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