Q8CIZ9 · NOX1_MOUSE

  • Protein
    NADPH oxidase 1
  • Gene
    Nox1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Isoform 1

NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor.

Isoform 2

NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Activity regulation

Isoform 2

The oxidase activity is potentiated by NOXA1 and NOXO1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site129Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue
Binding site143Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue
Binding site236Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue
Binding site248Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue
Binding site365-371FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentanchoring junction
Cellular Componentcell projection
Cellular Componentcytoplasm
Cellular Componentearly endosome
Cellular Componentendosome
Cellular ComponentNADPH oxidase complex
Cellular Componentplasma membrane
Molecular Functionmetal ion binding
Molecular FunctionNAD(P)H oxidase H2O2-forming activity
Molecular Functionsmall GTPase binding
Molecular Functionsuperoxide-generating NAD(P)H oxidase activity
Molecular Functionsuperoxide-generating NADPH oxidase activity
Biological Processangiogenesis
Biological Processcell chemotaxis
Biological Processcellular response to hyperoxia
Biological Processcellular stress response to acidic pH
Biological Processdefense response
Biological Processextracellular matrix organization
Biological Processglutathione metabolic process
Biological Processhydrogen peroxide metabolic process
Biological Processintracellular pH elevation
Biological Processintrinsic apoptotic signaling pathway in response to oxidative stress
Biological ProcessJNK cascade
Biological ProcessMAPK cascade
Biological Processnegative regulation of neuron maturation
Biological Processoxygen metabolic process
Biological Processpositive regulation of inclusion body assembly
Biological Processpositive regulation of integrin biosynthetic process
Biological Processpositive regulation of JNK cascade
Biological Processpositive regulation of MAPK cascade
Biological Processpositive regulation of neuron apoptotic process
Biological Processpositive regulation of neuron projection development
Biological Processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Biological Processpositive regulation of reactive oxygen species metabolic process
Biological Processpositive regulation of smooth muscle cell proliferation
Biological Processpositive regulation of superoxide anion generation
Biological Processpositive regulation of vascular associated smooth muscle cell migration
Biological Processpositive regulation of vascular associated smooth muscle cell proliferation
Biological Processpositive regulation of vascular endothelial growth factor production
Biological Processregulation of systemic arterial blood pressure by renin-angiotensin
Biological Processresponse to reactive oxygen species
Biological Processsuperoxide anion generation

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

Gene names

    • Name
      Nox1

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8CIZ9
  • Secondary accessions
    • A2AEK5
    • Q0KKX3
    • Q0KKX5
    • Q811U2

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-36Cytoplasmic
Transmembrane37-59Helical; Name=1
Topological domain60-72Extracellular
Transmembrane73-97Helical; Name=2
Topological domain98-130Cytoplasmic
Transmembrane131-151Helical; Name=3
Topological domain152-195Extracellular
Transmembrane196-216Helical; Name=4
Topological domain217-234Cytoplasmic
Transmembrane235-255Helical; Name=5
Topological domain256-423Extracellular
Transmembrane424-444Helical; Name=6
Topological domain445-591Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, modified residue.

TypeIDPosition(s)Description
ChainPRO_00003229821-591NADPH oxidase 1
Glycosylation189N-linked (GlcNAc...) asparagine
Glycosylation269N-linked (GlcNAc...) asparagine
Modified residue457Phosphothreonine

Post-translational modification

Phosphorylation at Thr-457 mediated by PKC/PRKBC positively regulates its interaction with NOXA1 and enzyme activity.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Isoform 2

Expressed in colon and vascular smooth muscle cells (VSMC).

Induction

Isoform 1

(c-type) induced in VSMC by angiotensin II and injury to the artery.

Gene expression databases

Interaction

Subunit

NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interacts with NOXO1. Interacts (via FAD-binding FR-type domain) with ARHGEF7 (via PH domain) (By similarity).
Interacts with NOXA1 (PubMed:16814099).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain82-316Ferric oxidoreductase
Domain317-418FAD-binding FR-type
Region424-563Interaction with NOXO1

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q8CIZ9-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    f-type, c-type
  • Note
    Product of f-type and c-type mRNA, which differ only in 5'-UTR.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    591
  • Mass (Da)
    68,193
  • Last updated
    2010-01-19 v2
  • Checksum
    B2D4AE54186A066B
MAGELRGSRGPLQRIQIAPREAPNLHLTMGNWLVNHWLSVLFLVSWLGLNIFLFVYAFLNYEKSDKYYYTREILGTALALARASALCLNFNSMMILIPVCRNLLSFLRGTCSFCNRTLRKPLDHNLTFHKLVAYMICIFTVIHIIAHLFNFERYRRSQQAMDGSLASVLSSLSHPEKEDSWLNPIQSPNMTVMYAAFTSIAGLTGVIATVALVLMVTSAMEFIRRNYFELFWYTHHLFIVYIICLGIHGLGGIVRGQTEESLGESHPHNCSHSFHEWDDHKGSCRHPHFAGHPPESWKWILAPIAFYIFERILRFYRSQQKVVITKVVMHPSNVLELQMRKRGFSMEVGQYIFVNCPSISFLEWHPFTLTSAPEEEFFSVHIRAAGDWTRNLIRTFEQQHSPMPRIEVDGPFGTVSEDVFQYEVAVLVGAGIGVTPFASILKSIWYKFQRADNKLKTQKIYFYWICRETGAFAWFNNLLNSLEQEMEELGKMDFLNYRLFLTGWDSNIAGHAALNFDRATDILTGLKQKTSFGRPMWDNEFSRIATAHPKSAVGVFLCGPRTLAKSLRKRCQRYSSLDPRKVQFYFNKETF

Q8CIZ9-2

  • Name
    2
  • Synonyms
    a-type
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q8CIZ9-3

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0R4J1X7A0A0R4J1X7_MOUSENox175
E0CYB0E0CYB0_MOUSENox1526

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0385741-28in isoform 2 and isoform 3
Alternative sequenceVSP_038575460-508in isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF539799
EMBL· GenBank· DDBJ
AAN75144.1
EMBL· GenBank· DDBJ
mRNA
AK136432
EMBL· GenBank· DDBJ
BAE22974.1
EMBL· GenBank· DDBJ
mRNA
AL671915
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AB206383
EMBL· GenBank· DDBJ
BAF03561.1
EMBL· GenBank· DDBJ
mRNA
AB206384
EMBL· GenBank· DDBJ
BAF03562.1
EMBL· GenBank· DDBJ
mRNA
AB206385
EMBL· GenBank· DDBJ
BAF03563.1
EMBL· GenBank· DDBJ
mRNA
AY174116
EMBL· GenBank· DDBJ
AAO20852.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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