Q8CIA5 · S35B4_MOUSE
- ProteinNucleotide sugar transporter SLC35B4
- GeneSlc35b4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids331 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for another nucleotide sugar. May couple UDP-alpha-D-glucuronate (UDP-GlcA) or UDP-alpha-D-xylose (UDP-Xyl) efflux to UDP-alpha-D-glucuronate (UDP-GlcA) influx into the ER lumen, which in turn stimulates glucuronidation and excretion of endobiotics and xenobiotics.
Catalytic activity
- UDP-N-acetyl-alpha-D-glucosamine(in) + UDP-alpha-D-glucuronate(out) = UDP-N-acetyl-alpha-D-glucosamine(out) + UDP-alpha-D-glucuronate(in)This reaction proceeds in the forward direction.
- UDP-alpha-D-xylose(in) + UDP-alpha-D-glucuronate(out) = UDP-alpha-D-xylose(out) + UDP-alpha-D-glucuronate(in)This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | Golgi apparatus | |
Molecular Function | UDP-N-acetylglucosamine transmembrane transporter activity | |
Molecular Function | UDP-xylose transmembrane transporter activity | |
Biological Process | regulation of gluconeogenesis |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNucleotide sugar transporter SLC35B4
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8CIA5
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 4-24 | Helical | ||||
Sequence: AFAVGLVFAGCCSNVIFLELL | ||||||
Transmembrane | 30-50 | Helical | ||||
Sequence: GCGNIVTFAQFLFIAVEGFLF | ||||||
Transmembrane | 59-79 | Helical | ||||
Sequence: PAIPIRYYAIMVTMFFTVSVV | ||||||
Transmembrane | 92-112 | Helical | ||||
Sequence: LHMIFRSGSLIANMILGIIIL | ||||||
Transmembrane | 124-144 | Helical | ||||
Sequence: IALVSAGIFICTFMSAKQVTV | ||||||
Transmembrane | 153-173 | Helical | ||||
Sequence: GFQAFAWWLLGIAALTFALLM | ||||||
Transmembrane | 201-221 | Helical | ||||
Sequence: ALPLPGFIFLASDIYDHVVLF | ||||||
Transmembrane | 229-249 | Helical | ||||
Sequence: VPVIGVTMPVMWFYLLMNVVT | ||||||
Transmembrane | 251-267 | Helical | ||||
Sequence: YVCIRGVFILTTECTSL | ||||||
Transmembrane | 268-288 | Helical | ||||
Sequence: TVTLVVTLRKFVSLIFSILYF | ||||||
Transmembrane | 294-314 | Helical | ||||
Sequence: MWHWLGTSFVFIGTLMYTEVW |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000213387 | 1-331 | Nucleotide sugar transporter SLC35B4 | |||
Sequence: MRPAFAVGLVFAGCCSNVIFLELLARTHPGCGNIVTFAQFLFIAVEGFLFEANLGRKPPAIPIRYYAIMVTMFFTVSVVNNYALNLNIAMPLHMIFRSGSLIANMILGIIILKKRYSMFKYTSIALVSAGIFICTFMSAKQVTVQTGLSDKDGFQAFAWWLLGIAALTFALLMSARMGIFQETLYRQFGKHSKEALFYNHALPLPGFIFLASDIYDHVVLFNKSELYQVPVIGVTMPVMWFYLLMNVVTQYVCIRGVFILTTECTSLTVTLVVTLRKFVSLIFSILYFQNQFTMWHWLGTSFVFIGTLMYTEVWKNLGTTKSELQKDDKKD |
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 326-331 | Mediates endoplasmic reticulum retention | ||||
Sequence: KDDKKD |
Sequence similarities
Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q8CIA5-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length331
- Mass (Da)37,517
- Last updated2005-11-22 v2
- Checksum72AA645C083C8BDA
Q8CIA5-2
- Name2
- Differences from canonical
- 1-172: Missing
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
S4R2P0 | S4R2P0_MOUSE | Slc35b4 | 41 |
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_016203 | 1-172 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 238 | in Ref. 3; AAH33512 | ||||
Sequence: V → I |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB041549 EMBL· GenBank· DDBJ | BAA95034.1 EMBL· GenBank· DDBJ | mRNA | ||
AK029969 EMBL· GenBank· DDBJ | BAC26707.1 EMBL· GenBank· DDBJ | mRNA | ||
AK033913 EMBL· GenBank· DDBJ | BAC28512.1 EMBL· GenBank· DDBJ | mRNA | ||
AK042150 EMBL· GenBank· DDBJ | BAC31186.1 EMBL· GenBank· DDBJ | mRNA | ||
AK138591 EMBL· GenBank· DDBJ | BAE23707.1 EMBL· GenBank· DDBJ | mRNA | ||
AK163299 EMBL· GenBank· DDBJ | BAE37285.1 EMBL· GenBank· DDBJ | mRNA | ||
BC033512 EMBL· GenBank· DDBJ | AAH33512.1 EMBL· GenBank· DDBJ | mRNA |