Q8CHY7 · TTC23_MOUSE

  • Protein
    Tetratricopeptide repeat protein 23
  • Gene
    Ttc23
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Participates positively in the ciliary Hedgehog (Hh) signaling.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcilium
Biological Processpositive regulation of smoothened signaling pathway

Names & Taxonomy

Protein names

  • Recommended name
    Tetratricopeptide repeat protein 23
  • Short names
    TPR repeat protein 23

Gene names

    • Name
      Ttc23

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8CHY7
  • Secondary accessions
    • Q9DAY3

Proteomes

Organism-specific databases

Subcellular Location

Note: Colocalizes with EVC and IQCE at the EvC zone of primary cilia.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002895491-488Tetratricopeptide repeat protein 23

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Associated with the EvC complex composed of EFCAB7, IQCE, EVC2 and EVC.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for repeat.

TypeIDPosition(s)Description
Repeat45-78TPR 1
Repeat137-170TPR 2
Repeat186-219TPR 3
Repeat228-261TPR 4
Repeat398-431TPR 5

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q8CHY7-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    488
  • Mass (Da)
    54,608
  • Last updated
    2003-03-01 v1
  • Checksum
    1FB806B8408651CF
MQESQDTHMSSHLDEVVAAVSVTSKNRIPNKLLQTALFQPPREKLHLCEERAKSYSSSREYKQAIQELVRCVALTRICYGDWHWKLAEAYVNLAQGYLQLKGLSLQAKQHAEKAKEILANSIESPCHNKTDIFKCSLELFYTLGRALLSLQKFKDASENLIKAERLSKEMLQCGNIVKEEWIEIQSRIKLSFAQLYQGQKRSKEAFPFYQKALEYTEITKDEKSLECVQVLRELAGVEQALGLYAAAISHFSRDRLPTPQPCPLGHKCCCPSPFLSPVLNVTWRPFYSSQVDEEEAHLIILSKDPSPEEAADSAHFIARAAAASGMHDHRDVAEKYFQESMTSIKDSEGAERAKFLSIQDEFCSFLQTTGQKERAAMILRESLEAKVGAFGDFSPEVAETYRALGRADLAQGNNSGAYAKLKKCVQIETFLYGSQDKKTLATQHTIDTLSKISEAAGKSRQSVKAKVAFCTSAPQYGMPGKGRHSVAD

Q8CHY7-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9QKU9E9QKU9_MOUSETtc23446
A0A140LHI7A0A140LHI7_MOUSETtc23252

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0260191-169in isoform 2
Alternative sequenceVSP_026020254-295in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK005431
EMBL· GenBank· DDBJ
BAB24025.1
EMBL· GenBank· DDBJ
mRNA
BC038179
EMBL· GenBank· DDBJ
AAH38179.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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