Q8CHT0 · AL4A1_MOUSE

  • Protein
    Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
  • Gene
    Aldh4a1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity).

Catalytic activity

Pathway

Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.

Features

Showing features for binding site, site, active site.

156250100150200250300350400450500550
TypeIDPosition(s)Description
Binding site207NAD+ (UniProtKB | ChEBI)
Site210Transition state stabilizer
Binding site232NAD+ (UniProtKB | ChEBI)
Binding site285-289NAD+ (UniProtKB | ChEBI)
Active site313Proton acceptor
Active site347Nucleophile
Binding site446NAD+ (UniProtKB | ChEBI)
Binding site512substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrial matrix
Cellular Componentmitochondrion
Molecular Function1-pyrroline-5-carboxylate dehydrogenase activity
Molecular Functionaldehyde dehydrogenase (NAD+) activity
Molecular Functionidentical protein binding
Biological Processproline catabolic process to glutamate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
  • EC number
  • Short names
    P5C dehydrogenase
  • Alternative names
    • Aldehyde dehydrogenase family 4 member A1
    • L-glutamate gamma-semialdehyde dehydrogenase

Gene names

    • Name
      Aldh4a1

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8CHT0
  • Secondary accessions
    • B1AXW8
    • Q7TND0
    • Q8BXM3
    • Q8R0N1
    • Q8R1S2

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for transit peptide, chain, modified residue.

TypeIDPosition(s)Description
Transit peptide1-23Mitochondrion
ChainPRO_000000717424-562Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
Modified residue30N6-succinyllysine
Modified residue43Phosphoserine
Modified residue51N6-acetyllysine
Modified residue92N6-acetyllysine; alternate
Modified residue92N6-succinyllysine; alternate
Modified residue98N6-acetyllysine; alternate
Modified residue98N6-succinyllysine; alternate
Modified residue113N6-acetyllysine; alternate
Modified residue113N6-succinyllysine; alternate
Modified residue129N6-acetyllysine; alternate
Modified residue129N6-succinyllysine; alternate
Modified residue174N6-acetyllysine; alternate
Modified residue174N6-succinyllysine; alternate
Modified residue317N6-acetyllysine
Modified residue346N6-succinyllysine
Modified residue357N6-acetyllysine; alternate
Modified residue357N6-succinyllysine; alternate
Modified residue364N6-acetyllysine
Modified residue375N6-acetyllysine
Modified residue394N6-succinyllysine
Modified residue461N6-acetyllysine
Modified residue508N6-acetyllysine; alternate
Modified residue508N6-succinyllysine; alternate
Modified residue530N6-acetyllysine
Modified residue551N6-acetyllysine

Post-translational modification

Acetylation of Lys-98, Lys-113 and Lys-401 is observed in liver mitochondria from fasted mice but not from fed mice.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    562
  • Mass (Da)
    61,841
  • Last updated
    2011-07-27 v3
  • Checksum
    4D8A0C9C68A99478
MLPLPSLRRSLLSHAWRGAGLRWKHTSSLKVTNEPILAFSQGSPERDALQKALKDLKGQMEAIPCVVGDEEVWTSDIQYQLSPFNHAHKVAKFCYADKALLNRAIDAALAARKEWDLKPMADRAQVFLKAADMLSGPRRAEVLAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKFAVELEGEQPISVPPSTNHTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPTFGDTVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGGKNFHFVHSSADVDSVVSGTLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKAFARIKKWLEHARSSPSLSILAGGQCNESVGYYVEPCIIESKDPQEPIMKEEIFGPVLTVYVYPDDKYRETLQLVDSTTSYGLTGAVFAQDKAIVQEATRMLRNAAGNFYINDKSTGSVVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWRYSYMQ

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict18in Ref. 1; BAC32045 and 4; AAH56226/AAH39281/AAH24133
Sequence conflict32in Ref. 1; BAC32045 and 4; AAH56226/AAH39281/AAH24133
Sequence conflict47in Ref. 1; BAC32045
Sequence conflict60in Ref. 1; BAC32045 and 4; AAH56226/AAH39281/AAH24133
Sequence conflict467in Ref. 1; BAC32045 and 4; AAH56226/AAH39281/AAH24133/AAH26589

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK044712
EMBL· GenBank· DDBJ
BAC32045.1
EMBL· GenBank· DDBJ
mRNA
AL831790
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH466615
EMBL· GenBank· DDBJ
EDL13315.1
EMBL· GenBank· DDBJ
Genomic DNA
BC024133
EMBL· GenBank· DDBJ
AAH24133.1
EMBL· GenBank· DDBJ
mRNA
BC026589
EMBL· GenBank· DDBJ
AAH26589.1
EMBL· GenBank· DDBJ
mRNA
BC039281
EMBL· GenBank· DDBJ
AAH39281.2
EMBL· GenBank· DDBJ
mRNA
BC056226
EMBL· GenBank· DDBJ
AAH56226.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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