Q8CHH1 · Q8CHH1_MOUSE
- Protein[histone H3]-lysine(4) N-methyltransferase
- GenemKIAA0304
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1744 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
Catalytic activity
- L-lysyl4-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteineThis reaction proceeds in the forward direction.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | histone H3K4 trimethyltransferase activity | |
Molecular Function | zinc ion binding | |
Biological Process | methylation | |
Biological Process | regulation of gene expression |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name[histone H3]-lysine(4) N-methyltransferase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8CHH1
Subcellular Location
PTM/Processing
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 13-60 | CXXC-type | ||||
Sequence: KKMRMARCGHCRGCLRVQDCGSCVNCLDKPKFGGPNTKKQCCVYRKCD | ||||||
Region | 81-125 | Disordered | ||||
Sequence: LLPWDSDESPEASPGPPGPRRGAGAGGSREEVGATPGPEEQDSLL | ||||||
Region | 137-187 | Disordered | ||||
Sequence: QRPSYDVFEDSDDSEPGGPPAPRRRTPREHELPVLEPEEQSRPRKPTLQPV | ||||||
Compositional bias | 152-179 | Basic and acidic residues | ||||
Sequence: PGGPPAPRRRTPREHELPVLEPEEQSRP | ||||||
Domain | 256-307 | PHD-type | ||||
Sequence: PMVCLLCASKGLHELVFCQVCCDPFHPFCLEEAERPSPQHRDTWCCRRCKFC | ||||||
Domain | 304-358 | PHD-type | ||||
Sequence: CKFCHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPTRATRRRRHWICSACVRC | ||||||
Domain | 390-451 | PHD-type | ||||
Sequence: GNYCPICTRCYEDNDYESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPDSVLYTCGPCAGA | ||||||
Region | 599-620 | Disordered | ||||
Sequence: RQQESETPESGQPPADPSAAFQ | ||||||
Domain | 633-741 | PHD-type | ||||
Sequence: PRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGSLKNVHAAVARGRQMRCELCLKPGATVGCCLSSCLSNFHFMCARASYCIFQDDKKVFCQKHT | ||||||
Region | 860-1031 | Disordered | ||||
Sequence: VHSPTPSSEPPNHDDLPDTDSLIPGDPVHHSPIQNLDPPLRTDSSNGPPPTPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDSDFPAPPRRSRRPSPLATRPPPSRRTSSPLRTSPQLRVPLSTSVTALTPTSGELAPPDLAPSPLPPSEDLGPDF | ||||||
Compositional bias | 896-911 | Polar residues | ||||
Sequence: DPPLRTDSSNGPPPTP | ||||||
Compositional bias | 965-979 | Pro residues | ||||
Sequence: RRSRRPSPLATRPPP | ||||||
Compositional bias | 980-1007 | Polar residues | ||||
Sequence: SRRTSSPLRTSPQLRVPLSTSVTALTPT | ||||||
Region | 1114-1162 | Disordered | ||||
Sequence: QLDGVDDGTDSEAEAVQQPRGQGTPPSGPGVGRGGVLGAAGDRARPPED | ||||||
Region | 1174-1218 | Disordered | ||||
Sequence: NLGGPGEGAAGPREDSLPSAPPLANGSQPPQSLSTSPADPTRTFA | ||||||
Compositional bias | 1199-1214 | Polar residues | ||||
Sequence: GSQPPQSLSTSPADPT | ||||||
Region | 1337-1439 | Disordered | ||||
Sequence: VSTFSGRSPPVPPPNKTPRLDEDGESLEDAHHVPGISGSGFSRVRMKTPTVRGVLDLNNPGEQPEEESPGESQWHHYSAGEASSSEEEPPSPEDKENQVPKRV | ||||||
Compositional bias | 1424-1439 | Basic and acidic residues | ||||
Sequence: EPPSPEDKENQVPKRV | ||||||
Domain | 1604-1720 | SET | ||||
Sequence: EAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYK | ||||||
Domain | 1728-1744 | Post-SET | ||||
Sequence: NKLPCNCGAKRCRRFLN |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length1,744
- Mass (Da)191,309
- Last updated2003-03-01 v1
- ChecksumA638E98F5E862747
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: H | ||||||
Compositional bias | 152-179 | Basic and acidic residues | ||||
Sequence: PGGPPAPRRRTPREHELPVLEPEEQSRP | ||||||
Compositional bias | 896-911 | Polar residues | ||||
Sequence: DPPLRTDSSNGPPPTP | ||||||
Compositional bias | 965-979 | Pro residues | ||||
Sequence: RRSRRPSPLATRPPP | ||||||
Compositional bias | 980-1007 | Polar residues | ||||
Sequence: SRRTSSPLRTSPQLRVPLSTSVTALTPT | ||||||
Compositional bias | 1199-1214 | Polar residues | ||||
Sequence: GSQPPQSLSTSPADPT | ||||||
Compositional bias | 1424-1439 | Basic and acidic residues | ||||
Sequence: EPPSPEDKENQVPKRV |