Q8CGE9 · RGS12_MOUSE
- ProteinRegulator of G-protein signaling 12
- GeneRgs12
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1381 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | apical dendrite | |
Cellular Component | cytoplasm | |
Cellular Component | dendrite | |
Cellular Component | neuronal cell body | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Cellular Component | protein-containing complex | |
Cellular Component | synapse | |
Molecular Function | G-protein alpha-subunit binding | |
Molecular Function | GTPase activator activity | |
Biological Process | regulation of G protein-coupled receptor signaling pathway | |
Biological Process | signal transduction | |
Biological Process | termination of G protein-coupled receptor signaling pathway |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRegulator of G-protein signaling 12
- Short namesRGS12
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8CGE9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue, cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000408474 | 1-1381 | Regulator of G-protein signaling 12 | |||
Sequence: MYRAGEPGKRQPGPAPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRAGDQILAINEINVKKASHEDVVKLIGKCSGVLHMVIAEGTSHVESCSSDEEGGLYEGKGWLRPKLDSKALGINRAERVVEEVQSGGIFNMIFESSSLCASGPEPLKLKQRSLSESAALRLDAGQAGLCAPHPSMLSKEDISKVINDDSVFTVGLDSHDDFGLDASILNVAMVVGYLGSIELPSTSSNLEHDSLQAIRGCMRRLRAEQKIHSLVTMKVMHDCVQLVTDRAGVVAEYPAEKLAFSAVCPDDRRFFGLVTMQTNDDGGLAQEDEGALRTSCHVFMVDPDLFHHKIHQGIARRFGFACTADPDTSGCLEFPASSLPVLQFISVLYRDMGELIEGVRARAFLDGDADAHQNNSTSSNSDSGIGNFNQEEKSNRVLVVDLGGGSSRHGQGSSPGWESGGGRGSQPWSAPWNGAFCHDSEAGSPLETSPNTDRFWDLTKHSGPVSHMEVPPATLRSSIPPSKRGAAGSSCGFNQRWLPVHVLQEWQCGHASDQESYTDSTDGWSSVNCGTLPPPMSKIPADRYRVEGSFAQAPLSTQKRDWSRKAFGMQNLFGPHRNVRKTKEDKKSSKLGRGVALAQTSQRTSARRSFGRSRRFSITRSLDDLESATVSDGELTGADLKDCISNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACECFSHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDILNAPHPDMFKEQQLQIFNLMKFDSYTRFLKSQLYQECVLAEVEGRTLPDSQQVPSSPASKHSISSDHSNVSTPKKLSGKSKSGRSLNEDVGEEDSEKKRRGAFFSWSRSRSTGRSQKKKDHGDHAHDAPHANGGLCRRESQGSVSSAGSLDLSEACRTSALEKDKAAKHCCVHLPDGTSCVVAVKSGFSIKEILSGLCERHGINGAAVDLFLVGGDKPLVLHQDSSILATRDLRLEKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVAKYGLDLGSLLVRLSGEKEPLDLGAPISSLDGQRVILEERDPSRGKVSTDKQKGAPVKQNSAVNSSPRNHLAMGEERTLGKSNSIKIRGENGKSARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQSNRADDQRGLLRKEDLVLPEFLRLPAGSSELALSSPPPVKGYSKRAVTGHGQEGAAQTEESYSDSPATSPASAQSPCSAYSPGSAHSPGSAHSTPGPPGTTQPGEKPTKPSCVSMVQEGTTQAWRRLSPEMEAGGIQTVEDEQVADLTLMGEGDISSPNSTLLPPPPTPQDTPGPPRPGTSRF | ||||||
Modified residue | 171 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 194 | Phosphoserine | ||||
Sequence: S | ||||||
Cross-link | 195 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Modified residue | 524 | Omega-N-methylarginine | ||||
Sequence: R | ||||||
Modified residue | 633 | Omega-N-methylarginine | ||||
Sequence: R | ||||||
Modified residue | 661 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 671 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 850 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 879 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 943 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in brain.
Developmental stage
Expressed in germinal vesicle oocyte, metaphase II oocyte and blastocyst (at protein level). Expressed in oocyte.
Gene expression databases
Interaction
Subunit
Interacts with GNAI1, GNAI2 and GNAI3; the interactions are GDP-dependent.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
XENO | Q8CGE9 | BRAF P15056 | 2 | EBI-7340552, EBI-365980 | |
BINARY | Q8CGE9 | Map2k2 Q63932 | 3 | EBI-7340552, EBI-397724 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 21-98 | PDZ | ||||
Sequence: SVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRAGDQILAINEINVKKASHEDVVKLIGKCSGVLHMVIAEGT | ||||||
Domain | 223-390 | PID | ||||
Sequence: SILNVAMVVGYLGSIELPSTSSNLEHDSLQAIRGCMRRLRAEQKIHSLVTMKVMHDCVQLVTDRAGVVAEYPAEKLAFSAVCPDDRRFFGLVTMQTNDDGGLAQEDEGALRTSCHVFMVDPDLFHHKIHQGIARRFGFACTADPDTSGCLEFPASSLPVLQFISVLYR | ||||||
Region | 409-429 | Disordered | ||||
Sequence: ADAHQNNSTSSNSDSGIGNFN | ||||||
Compositional bias | 410-429 | Polar residues | ||||
Sequence: DAHQNNSTSSNSDSGIGNFN | ||||||
Region | 442-528 | Disordered | ||||
Sequence: LGGGSSRHGQGSSPGWESGGGRGSQPWSAPWNGAFCHDSEAGSPLETSPNTDRFWDLTKHSGPVSHMEVPPATLRSSIPPSKRGAAG | ||||||
Region | 620-644 | Disordered | ||||
Sequence: RKTKEDKKSSKLGRGVALAQTSQRT | ||||||
Domain | 715-832 | RGS | ||||
Sequence: SFERLLQDPVGVRYFSDFLRKEFSEENILFWQACECFSHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDILNAPHPDMFKEQQLQIFNLMKFDSYTRFLKSQLYQECV | ||||||
Compositional bias | 842-874 | Polar residues | ||||
Sequence: PDSQQVPSSPASKHSISSDHSNVSTPKKLSGKS | ||||||
Region | 842-942 | Disordered | ||||
Sequence: PDSQQVPSSPASKHSISSDHSNVSTPKKLSGKSKSGRSLNEDVGEEDSEKKRRGAFFSWSRSRSTGRSQKKKDHGDHAHDAPHANGGLCRRESQGSVSSAG | ||||||
Compositional bias | 875-897 | Basic and acidic residues | ||||
Sequence: KSGRSLNEDVGEEDSEKKRRGAF | ||||||
Compositional bias | 910-927 | Basic and acidic residues | ||||
Sequence: QKKKDHGDHAHDAPHANG | ||||||
Domain | 962-1032 | RBD 1 | ||||
Sequence: KHCCVHLPDGTSCVVAVKSGFSIKEILSGLCERHGINGAAVDLFLVGGDKPLVLHQDSSILATRDLRLEKR | ||||||
Domain | 1034-1104 | RBD 2 | ||||
Sequence: LFRLDLVPINRSVGLKAKPTKPVTEVLRPVVAKYGLDLGSLLVRLSGEKEPLDLGAPISSLDGQRVILEER | ||||||
Region | 1102-1169 | Disordered | ||||
Sequence: EERDPSRGKVSTDKQKGAPVKQNSAVNSSPRNHLAMGEERTLGKSNSIKIRGENGKSARDPRLSKREE | ||||||
Compositional bias | 1117-1132 | Polar residues | ||||
Sequence: KGAPVKQNSAVNSSPR | ||||||
Compositional bias | 1154-1169 | Basic and acidic residues | ||||
Sequence: ENGKSARDPRLSKREE | ||||||
Domain | 1187-1209 | GoLoco | ||||
Sequence: AEEFFELISKAQSNRADDQRGLL | ||||||
Region | 1227-1318 | Disordered | ||||
Sequence: SELALSSPPPVKGYSKRAVTGHGQEGAAQTEESYSDSPATSPASAQSPCSAYSPGSAHSPGSAHSTPGPPGTTQPGEKPTKPSCVSMVQEGT | ||||||
Compositional bias | 1252-1318 | Polar residues | ||||
Sequence: GAAQTEESYSDSPATSPASAQSPCSAYSPGSAHSPGSAHSTPGPPGTTQPGEKPTKPSCVSMVQEGT | ||||||
Region | 1347-1381 | Disordered | ||||
Sequence: LMGEGDISSPNSTLLPPPPTPQDTPGPPRPGTSRF | ||||||
Compositional bias | 1358-1374 | Pro residues | ||||
Sequence: STLLPPPPTPQDTPGPP |
Domain
The GoLoco domain is necessary for interaction with GNAI1, GNAI2 and GNAI3.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,381
- Mass (Da)149,637
- Last updated2011-07-27 v2
- Checksum8897CD1D249B66C6
Computationally mapped potential isoform sequences
There are 11 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q3TTW9 | Q3TTW9_MOUSE | Rgs12 | 499 | ||
E9Q652 | E9Q652_MOUSE | Rgs12 | 1451 | ||
A0A0J9YU30 | A0A0J9YU30_MOUSE | Rgs12 | 185 | ||
E9Q1K7 | E9Q1K7_MOUSE | Rgs12 | 723 | ||
F7B2U5 | F7B2U5_MOUSE | Rgs12 | 236 | ||
D3YXA5 | D3YXA5_MOUSE | Rgs12 | 116 | ||
F6YRR2 | F6YRR2_MOUSE | Rgs12 | 107 | ||
D3Z0G5 | D3Z0G5_MOUSE | Rgs12 | 803 | ||
D3Z0G6 | D3Z0G6_MOUSE | Rgs12 | 733 | ||
D3Z0G7 | D3Z0G7_MOUSE | Rgs12 | 793 | ||
A0A286YDE1 | A0A286YDE1_MOUSE | Rgs12 | 78 |
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 410-429 | Polar residues | ||||
Sequence: DAHQNNSTSSNSDSGIGNFN | ||||||
Sequence conflict | 536 | in Ref. 2; AAH40396 | ||||
Sequence: R → K | ||||||
Compositional bias | 842-874 | Polar residues | ||||
Sequence: PDSQQVPSSPASKHSISSDHSNVSTPKKLSGKS | ||||||
Compositional bias | 875-897 | Basic and acidic residues | ||||
Sequence: KSGRSLNEDVGEEDSEKKRRGAF | ||||||
Compositional bias | 910-927 | Basic and acidic residues | ||||
Sequence: QKKKDHGDHAHDAPHANG | ||||||
Compositional bias | 1117-1132 | Polar residues | ||||
Sequence: KGAPVKQNSAVNSSPR | ||||||
Sequence conflict | 1135 | in Ref. 2; AAH40396 | ||||
Sequence: L → S | ||||||
Compositional bias | 1154-1169 | Basic and acidic residues | ||||
Sequence: ENGKSARDPRLSKREE | ||||||
Compositional bias | 1252-1318 | Polar residues | ||||
Sequence: GAAQTEESYSDSPATSPASAQSPCSAYSPGSAHSPGSAHSTPGPPGTTQPGEKPTKPSCVSMVQEGT | ||||||
Compositional bias | 1358-1374 | Pro residues | ||||
Sequence: STLLPPPPTPQDTPGPP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC126447 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC133204 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC040396 EMBL· GenBank· DDBJ | AAH40396.1 EMBL· GenBank· DDBJ | mRNA |