overexpression of the GluN2B carboxy terminus increased the total path of the dendritic arbor without affecting branch number or tortuosity of hippocampal pyramidal cells. Overexpressing the amino terminus and transmembrane domains of GluN2B had little effect.
Furthermore PrP(C) colocalized with both GluN2B and GluN2A in Prnp (+/+) . For the first time we demonstrate that PrP(C) is essential for REST-regulated NMDARs.
Semi-quantitative analysis of RNA levels in FMRP immunoprecipitates showed that in the mouse brain mRNAs encoding PSD components such as Shank1 SAPAP1-3 PSD-95 and the glutamate receptor subunits NR1 and NR2B are associated with FMRP.
The NR2B subunit-containing N-methyl-D-aspartate (NMDA) receptors accumulate on the synaptic site and are responsible for synaptic function and plasticity in the amygdala.
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