Q8CFR0 · C1QL2_MOUSE

  • Protein
    Complement C1q-like protein 2
  • Gene
    C1ql2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcerebellar climbing fiber to Purkinje cell synapse
Cellular Componentcollagen trimer
Cellular Componentextracellular region
Cellular Componentglutamatergic synapse
Cellular Componenthippocampal mossy fiber to CA3 synapse
Cellular Componentprotein-containing complex
Cellular Componentsynaptic cleft
Molecular Functionidentical protein binding
Biological Processneurotransmitter receptor localization to postsynaptic specialization membrane
Biological Processpostsynaptic density assembly
Biological Processregulation of synapse maturation

Names & Taxonomy

Protein names

  • Recommended name
    Complement C1q-like protein 2
  • Alternative names
    • C1q and tumor necrosis factor-related protein 10 (C1q/TNF-related protein 10; C1qTNF10; CTRP10)

Gene names

    • Name
      C1ql2
    • Synonyms
      C1qtnf10, Ctrp10

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8CFR0

Proteomes

Organism-specific databases

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis29No effect on homotrimer formation, but loss of higher-order oligomeric complexes; when associated with A-33. Does not affect heterooligomerization with C1QL4; when associated with A-33.
Mutagenesis33No effect on homotrimer formation, but loss of higher-order oligomeric complexes; when associated with A-29. Does not affect heterooligomerization with C1QL4; when associated with A-29.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 4 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_000027433622-287Complement C1q-like protein 2

Post-translational modification

Glycosylated, but not with N-linked glycans.

Keywords

Proteomic databases

Expression

Tissue specificity

Highest expression in eye, followed by placenta and brain, intermediate expression in adipose tissue and lowest expression in lymph node and testis.

Gene expression databases

Interaction

Subunit

Forms homotrimers which can further assemble to form higher-order oligomeric complexes. Interacts with ADGRB3. May interact with ERFE. Forms heterooligomers with C1QL3 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region65-144Disordered
Compositional bias70-105Pro residues
Domain76-118Collagen-like
Domain154-287C1q

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    287
  • Mass (Da)
    29,292
  • Last updated
    2003-03-01 v1
  • Checksum
    8FF89EC1C7420415
MALGLLIAVPLLLQAAPPGAAHYEMLGTCRMICDPYSVAPAGGPAGAKAPPPGPSTAALEVMQDLSANPPPPFIQGPKGDPGRPGKPGPRGPPGEPGPPGPRGPPGEKGDSGRPGLPGLQLTTSAAGGVGVVSGGTGGGGDTEGEVTSALSAAFSGPKIAFYVGLKSPHEGYEVLKFDDVVTNLGNHYDPTTGKFSCQVRGIYFFTYHILMRGGDGTSMWADLCKNGQVRASAIAQDADQNYDYASNSVVLHLDSGDEVYVKLDGGKAHGGNNNKYSTFSGFLLYPD

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias70-105Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ002402
EMBL· GenBank· DDBJ
AAY21934.1
EMBL· GenBank· DDBJ
mRNA
AK144471
EMBL· GenBank· DDBJ
BAE25906.1
EMBL· GenBank· DDBJ
mRNA
BC040774
EMBL· GenBank· DDBJ
AAH40774.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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