Q8CFF0 · PAR11_MOUSE
- ProteinProtein mono-ADP-ribosyltransferase PARP11
- GeneParp11
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids331 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (By similarity).
Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (PubMed:25673562).
Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (PubMed:25673562).
Catalytic activity
- L-aspartyl-[protein] + NAD+ = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide
- L-cysteinyl-[protein] + NAD+ = S-(ADP-D-ribosyl)-L-cysteinyl-[protein] + nicotinamide + H+
- L-glutamyl-[protein] + NAD+ = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide
- L-lysyl-[protein] + NAD+ = N6-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide + H+
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nuclear body | |
Cellular Component | nuclear envelope | |
Cellular Component | nuclear pore | |
Molecular Function | NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity | |
Molecular Function | NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity | |
Molecular Function | NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity | |
Molecular Function | NAD+-protein ADP-ribosyltransferase activity | |
Molecular Function | NAD+-protein poly-ADP-ribosyltransferase activity | |
Molecular Function | NAD+-protein-aspartate ADP-ribosyltransferase activity | |
Molecular Function | NAD+-protein-cysteine ADP-ribosyltransferase activity | |
Molecular Function | NAD+-protein-lysine ADP-ribosyltransferase activity | |
Molecular Function | nucleotidyltransferase activity | |
Biological Process | cell differentiation | |
Biological Process | mRNA transport | |
Biological Process | nuclear envelope organization | |
Biological Process | protein auto-ADP-ribosylation | |
Biological Process | protein transport | |
Biological Process | spermatogenesis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein mono-ADP-ribosyltransferase PARP11
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8CFF0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Colocalizes with NUP153 at nuclear pores.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Knockout mice are viable and are born in normal Mendelian ratios. Knockout males, but not females, exhibit a striking fertility defect, with the majority of males being sterile and a minority producing infrequent and small litters. Sperm from mutant mice exhibits mild to severe teratozoospermia, with structural defects in elongating spermatid nuclear envelope and chromatin detachment associated with abnormal nuclear shaping.
Variants
![](/variants.8e7f84.jpg)
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 15 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000273420 | 1-331 | Protein mono-ADP-ribosyltransferase PARP11 | ||
Modified residue | 11 | N6-(ADP-ribosyl)lysine | |||
Modified residue | 49 | ADP-ribosylcysteine | |||
Modified residue | 65 | ADP-ribosylcysteine | |||
Modified residue | 80 | ADP-ribosyl aspartic acid | |||
Post-translational modification
Auto-mono-ADP-ribosylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Predominantly expressed in testis, preferentially in postmeiotic germ cells. Also detectable in other tissues, including liver, lung, spleen, thymus and brain.
Developmental stage
Undetectable in testis until postnatal day 18. Sharply up-regulated from postnatal days 18 to 21. This timeframe corresponds to the appearance of the first spermatids of the first wave of spermatogenesis just before initiation of elongation. Remains elevated in adult animals.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 15-99 | WWE | |||
Domain | 116-331 | PARP catalytic | |||
Sequence similarities
Belongs to the ARTD/PARP family.
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q8CFF0-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length331
- Mass (Da)38,737
- Last updated2003-03-01 v1
- MD5 Checksum4358B9B12A8F749BF76378DE67992659
Q8CFF0-2
- Name2
- Differences from canonical
- 1-83: Missing
Q8CFF0-3
- Name3
- Differences from canonical
- 177-331: Missing
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0J9YVC5 | A0A0J9YVC5_MOUSE | Parp11 | 43 |
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Alternative sequence | VSP_022557 | 1-83 | in isoform 2 | ||
Alternative sequence | VSP_022558 | 177-331 | in isoform 3 | ||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK133697 EMBL· GenBank· DDBJ | BAE21788.1 EMBL· GenBank· DDBJ | mRNA | ||
AK151393 EMBL· GenBank· DDBJ | BAE30362.1 EMBL· GenBank· DDBJ | mRNA | ||
BC040269 EMBL· GenBank· DDBJ | AAH40269.1 EMBL· GenBank· DDBJ | mRNA |