Q8CFC2 · MYT1_MOUSE

  • Protein
    Myelin transcription factor 1
  • Gene
    Myt1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription (By similarity).

Features

Showing features for binding site.

111271002003004005006007008009001,0001,100
TypeIDPosition(s)Description
Binding site30Zn2+ 1 (UniProtKB | ChEBI)
Binding site35Zn2+ 1 (UniProtKB | ChEBI)
Binding site48Zn2+ 1 (UniProtKB | ChEBI)
Binding site54Zn2+ 1 (UniProtKB | ChEBI)
Binding site444Zn2+ 2 (UniProtKB | ChEBI)
Binding site449Zn2+ 2 (UniProtKB | ChEBI)
Binding site462Zn2+ 2 (UniProtKB | ChEBI)
Binding site468Zn2+ 2 (UniProtKB | ChEBI)
Binding site488Zn2+ 3 (UniProtKB | ChEBI)
Binding site493Zn2+ 3 (UniProtKB | ChEBI)
Binding site506Zn2+ 3 (UniProtKB | ChEBI)
Binding site512Zn2+ 3 (UniProtKB | ChEBI)
Binding site802Zn2+ 4 (UniProtKB | ChEBI)
Binding site807Zn2+ 4 (UniProtKB | ChEBI)
Binding site820Zn2+ 4 (UniProtKB | ChEBI)
Binding site826Zn2+ 4 (UniProtKB | ChEBI)
Binding site846Zn2+ 5 (UniProtKB | ChEBI)
Binding site851Zn2+ 5 (UniProtKB | ChEBI)
Binding site864Zn2+ 5 (UniProtKB | ChEBI)
Binding site870Zn2+ 5 (UniProtKB | ChEBI)
Binding site895Zn2+ 6 (UniProtKB | ChEBI)
Binding site900Zn2+ 6 (UniProtKB | ChEBI)
Binding site913Zn2+ 6 (UniProtKB | ChEBI)
Binding site919Zn2+ 6 (UniProtKB | ChEBI)
Binding site948Zn2+ 7 (UniProtKB | ChEBI)
Binding site953Zn2+ 7 (UniProtKB | ChEBI)
Binding site966Zn2+ 7 (UniProtKB | ChEBI)
Binding site972Zn2+ 7 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Functioncis-regulatory region sequence-specific DNA binding
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Functionzinc ion binding
Biological Processcell differentiation
Biological Processdiaphragm development
Biological Processendocrine pancreas development
Biological Processintracellular glucose homeostasis
Biological Processnegative regulation of gene expression
Biological Processnervous system development
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpost-embryonic development
Biological Processregulation of hormone metabolic process
Biological Processregulation of insulin secretion involved in cellular response to glucose stimulus

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Myelin transcription factor 1
  • Short names
    MyT1
  • Alternative names
    • Neural zinc finger factor 2 (NZF-2)

Gene names

    • Name
      Myt1
    • Synonyms
      Kiaa0835, Nzf2

Organism names

  • Taxonomic identifier
  • Strains
    • ICR
    • C57BL/6J
    • OF1
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8CFC2
  • Secondary accessions
    • B0R0C3
    • B0R0C4
    • O08995
    • Q8CFH1

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000966771-1127Myelin transcription factor 1

Proteomic databases

PTM databases

Expression

Tissue specificity

Isoform 1 is more predominant than isoform 2 at all stages of development and adulthood. Expressed in differentiated neurons especially at higher levels in newly generated ones.

Developmental stage

Isoform 1 is detected in the earliest born neurons. At 9.5 dpc it is detected in the ventrolateral part of the spinal cord, which later become motor neurons and is also detected in the dispersed cells of the alar plate interneurons. During spinal cord development, the expression is highest in the latest born neurons (the subventricular zone). Detected in the early differentiated neurons within the neuroepithelium and the neural crest cells at 9.5 dpc. At 12.5 dpc, detected in the differentiated neurons within the forebrain, midbrain, and hindbrain. In these neurons, the expression level is highest in the latest born neurons and is also detected in the differentiated neurons of the sensory organs and the peripheral ganglia.

Gene expression databases

Interaction

Subunit

Interacts with STEAP3.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for compositional bias, region, zinc finger.

TypeIDPosition(s)Description
Compositional bias1-16Basic and acidic residues
Region1-157Disordered
Zinc finger21-64CCHHC-type 1
Compositional bias56-107Basic and acidic residues
Compositional bias119-133Basic and acidic residues
Compositional bias140-157Polar residues
Region204-369Disordered
Compositional bias213-230Basic and acidic residues
Compositional bias260-311Acidic residues
Compositional bias345-366Basic and acidic residues
Zinc finger435-478CCHHC-type 2
Zinc finger479-522CCHHC-type 3
Region520-542Disordered
Compositional bias527-542Polar residues
Compositional bias670-684Basic and acidic residues
Region670-776Disordered
Compositional bias685-727Polar residues
Compositional bias728-752Basic and acidic residues
Zinc finger793-836CCHHC-type 4
Zinc finger837-880CCHHC-type 5
Zinc finger886-929CCHHC-type 6
Zinc finger939-982CCHHC-type 7

Domain

Contains 7 zinc fingers of the C2HC class arranged in two widely separated clusters. These two domains of DNA binding can function independently and recognize the same DNA sequence.

Sequence similarities

Belongs to the MYT1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q8CFC2-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    NZF-2b
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    1,127
  • Mass (Da)
    123,576
  • Last updated
    2003-03-01 v1
  • Checksum
    CB46958837E50008
MSSESDDKRARTRSKTLRGPPETTGADLSCPTPGCTGSGHVRGKYSRHRSLQSCPLAKKRKLEDAETEHLVSKRKSHPLRLALDEGYRMDSDGSEDAEVKDVSVSDESEGPLEEAEAEMSGQEEIHHPQTAEGKSLIKPHFDSNPTSSPSGFSKSSYSSYQGIIATSLLNLGQIAEEALVKEDSVSVAKLSPTVVHQLQDEAAMGVNSDEGEKDLFIQPEDVEEVIEVTSERSQEPCPQSLKDMVSEESSKQKGVLGHEEEGEEEEEDEEEEDEEEEEEGEEGEEEEEEEEEEEEEEDEEEEEEEEEAAPNVIFGEDTSHTSVQKASPEFRGPELSSPKPEYSVIVEVRSDDDKDEDSRSQKSAVTDESEMYDMMTRGNLGLLEQAIALKAEQVRAVCESGCPPAEQGHLGPGEPGKMAKPLDVVRKSCYSKDPSRVEKREIKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRIPPEILAMHENVLKCPTPGCTGQGHVNSNRNTHRSLSGCPIAAAEKLAKSHEKQQLQTGDPPKNNSNSDRILRPMCFVKQLEVPPYGSYRPNVAPATPRANLAKELEKFSKVTFDYASFDAQVFGKRMLAPKIQTSETSPKAFQCFDYSHDAEAAHMAATAILNLSTRCWEMPENLSTKPQDLPSKAVDIEVDENGTLDLSMHKHRKRENTFPSSSSCSSSPGVKSPDVSQRQSSTSAPSSSMTSPQSSQASRQDEWDRPLDYTKPSRLREEEPEESEPAAHSFASSEADDQEVSEENFEERKYPGEVTLTNFKLKFLSKDIKKELLTCPTPGCDGSGHITGNYASHRSLSGCPLADKSLRNLMAAHSADLKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGLKVAPTKDDKEDPELMKCPVPGCVGLGHISGKYASHRSASGCPLAARRQKEGALNGSSFSWKSLKNEGPTCPTPGCDGSGHANGSFLTHRSLSGCPRATFAGKKGKLSGDEILSPKFKTSDVLENDEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQALIQSLANIRLPHMEPICEQNFDAYVNTLTDMYSNQDCYQNPENKGLLETIKQAVRGIQV

Q8CFC2-2

  • Name
    2
  • Synonyms
    NZF-2a
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-152: MSSESDDKRARTRSKTLRGPPETTGADLSCPTPGCTGSGHVRGKYSRHRSLQSCPLAKKRKLEDAETEHLVSKRKSHPLRLALDEGYRMDSDGSEDAEVKDVSVSDESEGPLEEAEAEMSGQEEIHHPQTAEGKSLIKPHFDSNPTSSPSGF → MMDGIGIRTEKYQSNLAKIDSFLVFESRQKADRMAYSSFPYFLSYSAESGQVGIGGELATVGSRDLETFPHALFKAPLFLVLCRKKPHQAPFLLQPHKQPFWL

Q8CFC2-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
V9GXW7V9GXW7_MOUSEMyt136
B0R0C1B0R0C1_MOUSEMyt11169
B0R0C6B0R0C6_MOUSEMyt1121
F6SWU2F6SWU2_MOUSEMyt1787
F7CGS5F7CGS5_MOUSEMyt1604

Sequence caution

The sequence BAC41451.2 differs from that shown. Reason: Erroneous initiation

Features

Showing features for compositional bias, alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-16Basic and acidic residues
Alternative sequenceVSP_0157201-152in isoform 2
Compositional bias56-107Basic and acidic residues
Compositional bias119-133Basic and acidic residues
Compositional bias140-157Polar residues
Compositional bias213-230Basic and acidic residues
Sequence conflict238in Ref. 1; AAC53456
Compositional bias260-311Acidic residues
Compositional bias345-366Basic and acidic residues
Sequence conflict446in Ref. 1; AAC53456
Sequence conflict502in Ref. 1; AAC53456
Alternative sequenceVSP_015721508-545in isoform 3
Compositional bias527-542Polar residues
Compositional bias670-684Basic and acidic residues
Compositional bias685-727Polar residues
Sequence conflict701in Ref. 1; AAC53456
Compositional bias728-752Basic and acidic residues
Sequence conflict879in Ref. 1; AAC53456
Sequence conflict1022in Ref. 1; AAC53456
Sequence conflict1039in Ref. 1; AAC53456

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF004294
EMBL· GenBank· DDBJ
AAC53456.1
EMBL· GenBank· DDBJ
mRNA
AB082378
EMBL· GenBank· DDBJ
BAC16512.1
EMBL· GenBank· DDBJ
mRNA
AB093267
EMBL· GenBank· DDBJ
BAC41451.2
EMBL· GenBank· DDBJ
mRNA Different initiation
AL845173
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC063252
EMBL· GenBank· DDBJ
AAH63252.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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