Q8CFC2 · MYT1_MOUSE
- ProteinMyelin transcription factor 1
- GeneMyt1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1127 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription (By similarity).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 30 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 35 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 48 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 54 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 444 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 449 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 462 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 468 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 488 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 493 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 506 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 512 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 802 | Zn2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 807 | Zn2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 820 | Zn2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 826 | Zn2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 846 | Zn2+ 5 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 851 | Zn2+ 5 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 864 | Zn2+ 5 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 870 | Zn2+ 5 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 895 | Zn2+ 6 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 900 | Zn2+ 6 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 913 | Zn2+ 6 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 919 | Zn2+ 6 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 948 | Zn2+ 7 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 953 | Zn2+ 7 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 966 | Zn2+ 7 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 972 | Zn2+ 7 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | cis-regulatory region sequence-specific DNA binding | |
Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
Molecular Function | RNA polymerase II transcription regulatory region sequence-specific DNA binding | |
Molecular Function | zinc ion binding | |
Biological Process | cell differentiation | |
Biological Process | diaphragm development | |
Biological Process | endocrine pancreas development | |
Biological Process | intracellular glucose homeostasis | |
Biological Process | negative regulation of gene expression | |
Biological Process | nervous system development | |
Biological Process | positive regulation of gene expression | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | post-embryonic development | |
Biological Process | regulation of hormone metabolic process | |
Biological Process | regulation of insulin secretion involved in cellular response to glucose stimulus |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameMyelin transcription factor 1
- Short namesMyT1
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8CFC2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000096677 | 1-1127 | Myelin transcription factor 1 | |||
Sequence: MSSESDDKRARTRSKTLRGPPETTGADLSCPTPGCTGSGHVRGKYSRHRSLQSCPLAKKRKLEDAETEHLVSKRKSHPLRLALDEGYRMDSDGSEDAEVKDVSVSDESEGPLEEAEAEMSGQEEIHHPQTAEGKSLIKPHFDSNPTSSPSGFSKSSYSSYQGIIATSLLNLGQIAEEALVKEDSVSVAKLSPTVVHQLQDEAAMGVNSDEGEKDLFIQPEDVEEVIEVTSERSQEPCPQSLKDMVSEESSKQKGVLGHEEEGEEEEEDEEEEDEEEEEEGEEGEEEEEEEEEEEEEEDEEEEEEEEEAAPNVIFGEDTSHTSVQKASPEFRGPELSSPKPEYSVIVEVRSDDDKDEDSRSQKSAVTDESEMYDMMTRGNLGLLEQAIALKAEQVRAVCESGCPPAEQGHLGPGEPGKMAKPLDVVRKSCYSKDPSRVEKREIKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRIPPEILAMHENVLKCPTPGCTGQGHVNSNRNTHRSLSGCPIAAAEKLAKSHEKQQLQTGDPPKNNSNSDRILRPMCFVKQLEVPPYGSYRPNVAPATPRANLAKELEKFSKVTFDYASFDAQVFGKRMLAPKIQTSETSPKAFQCFDYSHDAEAAHMAATAILNLSTRCWEMPENLSTKPQDLPSKAVDIEVDENGTLDLSMHKHRKRENTFPSSSSCSSSPGVKSPDVSQRQSSTSAPSSSMTSPQSSQASRQDEWDRPLDYTKPSRLREEEPEESEPAAHSFASSEADDQEVSEENFEERKYPGEVTLTNFKLKFLSKDIKKELLTCPTPGCDGSGHITGNYASHRSLSGCPLADKSLRNLMAAHSADLKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGLKVAPTKDDKEDPELMKCPVPGCVGLGHISGKYASHRSASGCPLAARRQKEGALNGSSFSWKSLKNEGPTCPTPGCDGSGHANGSFLTHRSLSGCPRATFAGKKGKLSGDEILSPKFKTSDVLENDEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQALIQSLANIRLPHMEPICEQNFDAYVNTLTDMYSNQDCYQNPENKGLLETIKQAVRGIQV |
Proteomic databases
PTM databases
Expression
Tissue specificity
Isoform 1 is more predominant than isoform 2 at all stages of development and adulthood. Expressed in differentiated neurons especially at higher levels in newly generated ones.
Developmental stage
Isoform 1 is detected in the earliest born neurons. At 9.5 dpc it is detected in the ventrolateral part of the spinal cord, which later become motor neurons and is also detected in the dispersed cells of the alar plate interneurons. During spinal cord development, the expression is highest in the latest born neurons (the subventricular zone). Detected in the early differentiated neurons within the neuroepithelium and the neural crest cells at 9.5 dpc. At 12.5 dpc, detected in the differentiated neurons within the forebrain, midbrain, and hindbrain. In these neurons, the expression level is highest in the latest born neurons and is also detected in the differentiated neurons of the sensory organs and the peripheral ganglia.
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-16 | Basic and acidic residues | ||||
Sequence: MSSESDDKRARTRSKT | ||||||
Region | 1-157 | Disordered | ||||
Sequence: MSSESDDKRARTRSKTLRGPPETTGADLSCPTPGCTGSGHVRGKYSRHRSLQSCPLAKKRKLEDAETEHLVSKRKSHPLRLALDEGYRMDSDGSEDAEVKDVSVSDESEGPLEEAEAEMSGQEEIHHPQTAEGKSLIKPHFDSNPTSSPSGFSKSSY | ||||||
Zinc finger | 21-64 | CCHHC-type 1 | ||||
Sequence: PETTGADLSCPTPGCTGSGHVRGKYSRHRSLQSCPLAKKRKLED | ||||||
Compositional bias | 56-107 | Basic and acidic residues | ||||
Sequence: LAKKRKLEDAETEHLVSKRKSHPLRLALDEGYRMDSDGSEDAEVKDVSVSDE | ||||||
Compositional bias | 119-133 | Basic and acidic residues | ||||
Sequence: MSGQEEIHHPQTAEG | ||||||
Compositional bias | 140-157 | Polar residues | ||||
Sequence: HFDSNPTSSPSGFSKSSY | ||||||
Region | 204-369 | Disordered | ||||
Sequence: MGVNSDEGEKDLFIQPEDVEEVIEVTSERSQEPCPQSLKDMVSEESSKQKGVLGHEEEGEEEEEDEEEEDEEEEEEGEEGEEEEEEEEEEEEEEDEEEEEEEEEAAPNVIFGEDTSHTSVQKASPEFRGPELSSPKPEYSVIVEVRSDDDKDEDSRSQKSAVTDES | ||||||
Compositional bias | 213-230 | Basic and acidic residues | ||||
Sequence: KDLFIQPEDVEEVIEVTS | ||||||
Compositional bias | 260-311 | Acidic residues | ||||
Sequence: EEGEEEEEDEEEEDEEEEEEGEEGEEEEEEEEEEEEEEDEEEEEEEEEAAPN | ||||||
Compositional bias | 345-366 | Basic and acidic residues | ||||
Sequence: IVEVRSDDDKDEDSRSQKSAVT | ||||||
Zinc finger | 435-478 | CCHHC-type 2 | ||||
Sequence: SRVEKREIKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRIPPEI | ||||||
Zinc finger | 479-522 | CCHHC-type 3 | ||||
Sequence: LAMHENVLKCPTPGCTGQGHVNSNRNTHRSLSGCPIAAAEKLAK | ||||||
Region | 520-542 | Disordered | ||||
Sequence: LAKSHEKQQLQTGDPPKNNSNSD | ||||||
Compositional bias | 527-542 | Polar residues | ||||
Sequence: QQLQTGDPPKNNSNSD | ||||||
Compositional bias | 670-684 | Basic and acidic residues | ||||
Sequence: TLDLSMHKHRKRENT | ||||||
Region | 670-776 | Disordered | ||||
Sequence: TLDLSMHKHRKRENTFPSSSSCSSSPGVKSPDVSQRQSSTSAPSSSMTSPQSSQASRQDEWDRPLDYTKPSRLREEEPEESEPAAHSFASSEADDQEVSEENFEERK | ||||||
Compositional bias | 685-727 | Polar residues | ||||
Sequence: FPSSSSCSSSPGVKSPDVSQRQSSTSAPSSSMTSPQSSQASRQ | ||||||
Compositional bias | 728-752 | Basic and acidic residues | ||||
Sequence: DEWDRPLDYTKPSRLREEEPEESEP | ||||||
Zinc finger | 793-836 | CCHHC-type 4 | ||||
Sequence: KDIKKELLTCPTPGCDGSGHITGNYASHRSLSGCPLADKSLRNL | ||||||
Zinc finger | 837-880 | CCHHC-type 5 | ||||
Sequence: MAAHSADLKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGLKV | ||||||
Zinc finger | 886-929 | CCHHC-type 6 | ||||
Sequence: DKEDPELMKCPVPGCVGLGHISGKYASHRSASGCPLAARRQKEG | ||||||
Zinc finger | 939-982 | CCHHC-type 7 | ||||
Sequence: KSLKNEGPTCPTPGCDGSGHANGSFLTHRSLSGCPRATFAGKKG |
Domain
Contains 7 zinc fingers of the C2HC class arranged in two widely separated clusters. These two domains of DNA binding can function independently and recognize the same DNA sequence.
Sequence similarities
Belongs to the MYT1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q8CFC2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsNZF-2b
- Length1,127
- Mass (Da)123,576
- Last updated2003-03-01 v1
- ChecksumCB46958837E50008
Q8CFC2-2
- Name2
- SynonymsNZF-2a
- Differences from canonical
- 1-152: MSSESDDKRARTRSKTLRGPPETTGADLSCPTPGCTGSGHVRGKYSRHRSLQSCPLAKKRKLEDAETEHLVSKRKSHPLRLALDEGYRMDSDGSEDAEVKDVSVSDESEGPLEEAEAEMSGQEEIHHPQTAEGKSLIKPHFDSNPTSSPSGF → MMDGIGIRTEKYQSNLAKIDSFLVFESRQKADRMAYSSFPYFLSYSAESGQVGIGGELATVGSRDLETFPHALFKAPLFLVLCRKKPHQAPFLLQPHKQPFWL
Q8CFC2-3
- Name3
- Differences from canonical
- 508-545: Missing
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for compositional bias, alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-16 | Basic and acidic residues | ||||
Sequence: MSSESDDKRARTRSKT | ||||||
Alternative sequence | VSP_015720 | 1-152 | in isoform 2 | |||
Sequence: MSSESDDKRARTRSKTLRGPPETTGADLSCPTPGCTGSGHVRGKYSRHRSLQSCPLAKKRKLEDAETEHLVSKRKSHPLRLALDEGYRMDSDGSEDAEVKDVSVSDESEGPLEEAEAEMSGQEEIHHPQTAEGKSLIKPHFDSNPTSSPSGF → MMDGIGIRTEKYQSNLAKIDSFLVFESRQKADRMAYSSFPYFLSYSAESGQVGIGGELATVGSRDLETFPHALFKAPLFLVLCRKKPHQAPFLLQPHKQPFWL | ||||||
Compositional bias | 56-107 | Basic and acidic residues | ||||
Sequence: LAKKRKLEDAETEHLVSKRKSHPLRLALDEGYRMDSDGSEDAEVKDVSVSDE | ||||||
Compositional bias | 119-133 | Basic and acidic residues | ||||
Sequence: MSGQEEIHHPQTAEG | ||||||
Compositional bias | 140-157 | Polar residues | ||||
Sequence: HFDSNPTSSPSGFSKSSY | ||||||
Compositional bias | 213-230 | Basic and acidic residues | ||||
Sequence: KDLFIQPEDVEEVIEVTS | ||||||
Sequence conflict | 238 | in Ref. 1; AAC53456 | ||||
Sequence: P → R | ||||||
Compositional bias | 260-311 | Acidic residues | ||||
Sequence: EEGEEEEEDEEEEDEEEEEEGEEGEEEEEEEEEEEEEEDEEEEEEEEEAAPN | ||||||
Compositional bias | 345-366 | Basic and acidic residues | ||||
Sequence: IVEVRSDDDKDEDSRSQKSAVT | ||||||
Sequence conflict | 446 | in Ref. 1; AAC53456 | ||||
Sequence: T → A | ||||||
Sequence conflict | 502 | in Ref. 1; AAC53456 | ||||
Sequence: N → Y | ||||||
Alternative sequence | VSP_015721 | 508-545 | in isoform 3 | |||
Sequence: Missing | ||||||
Compositional bias | 527-542 | Polar residues | ||||
Sequence: QQLQTGDPPKNNSNSD | ||||||
Compositional bias | 670-684 | Basic and acidic residues | ||||
Sequence: TLDLSMHKHRKRENT | ||||||
Compositional bias | 685-727 | Polar residues | ||||
Sequence: FPSSSSCSSSPGVKSPDVSQRQSSTSAPSSSMTSPQSSQASRQ | ||||||
Sequence conflict | 701 | in Ref. 1; AAC53456 | ||||
Sequence: D → G | ||||||
Compositional bias | 728-752 | Basic and acidic residues | ||||
Sequence: DEWDRPLDYTKPSRLREEEPEESEP | ||||||
Sequence conflict | 879 | in Ref. 1; AAC53456 | ||||
Sequence: K → R | ||||||
Sequence conflict | 1022 | in Ref. 1; AAC53456 | ||||
Sequence: E → G | ||||||
Sequence conflict | 1039 | in Ref. 1; AAC53456 | ||||
Sequence: K → R |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF004294 EMBL· GenBank· DDBJ | AAC53456.1 EMBL· GenBank· DDBJ | mRNA | ||
AB082378 EMBL· GenBank· DDBJ | BAC16512.1 EMBL· GenBank· DDBJ | mRNA | ||
AB093267 EMBL· GenBank· DDBJ | BAC41451.2 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AL845173 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC063252 EMBL· GenBank· DDBJ | AAH63252.1 EMBL· GenBank· DDBJ | mRNA |