Q8CBC4 · CNST_MOUSE

  • Protein
    Consortin
  • Gene
    Cnst
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Required for targeting of connexins to the plasma membrane.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Cellular Componentprotein-containing complex
Cellular Componenttrans-Golgi network
Cellular Componenttransport vesicle
Molecular Functionconnexin binding
Molecular Functionphosphatase binding
Biological Processpositive regulation of Golgi to plasma membrane protein transport

Names & Taxonomy

Protein names

  • Recommended name
    Consortin

Gene names

    • Name
      Cnst

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8CBC4
  • Secondary accessions
    • Q8BFS5
    • Q8K053

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass membrane protein
Golgi apparatus, trans-Golgi network membrane
; Single-pass membrane protein
Note: Located predominantly in the trans-Golgi network. Probably trafficks between the trans-Golgi network and the cell membrane via the secretory pathway (By similarity).

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-650Cytoplasmic
Transmembrane651-671Helical
Topological domain672-711Extracellular

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis558-562Does not affect binding to connexins but results in their intracellular accumulation.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 55 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002889071-711Consortin

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with connexins GJA1/CX43, GJB1/CX32, GJB2/CX26, GJB3/CX31, GJB6/CX30 and GJC1/CX45. Also interacts with GGA1 and GGA2. Does not interact with PANX1.

Binary interactions

Type
Entry 1Entry 2Number of experimentsIntAct
BINARY Q8CBC4-3Gga1 Q8R0H92EBI-2615407, EBI-2616212
BINARY Q8CBC4-3Gga2 Q6P5E62EBI-2615407, EBI-2616239
XENO Q8CBC4-3Gjb2 P219942EBI-2615407, EBI-2616119

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region1-157Disordered
Compositional bias20-34Basic and acidic residues
Compositional bias57-90Polar residues
Region294-332Disordered
Compositional bias312-327Basic and acidic residues
Region370-389Disordered
Region394-432Disordered
Region457-496Disordered
Compositional bias476-490Polar residues

Sequence similarities

Belongs to the CNST family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q8CBC4-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    711
  • Mass (Da)
    76,866
  • Last updated
    2003-03-01 v1
  • Checksum
    B117F1FA8648E8EC
MDDSDPPTYSLQIEPQDGCHPGDSVERRVTRLPSVSDENENQLAGDGPAGLTTSEGAMGRATVSEQDSLNNNESFPSSCEAAPTENAENTPSEGPKDDPPSLGQDQKLPAKRSPRAKKSSPKSAPPGDAVPVMQTQNATSQAAGEEEAAGVNANDPPKAPALQPLFSLIRGEVAQMDSRALPLFLHQVAETYFQEEDYEKAMKFIQLERLYHEQLLANLSAIQEQWETKWKAVQPRTVTPLRNSEKGFNGEDFEQLAKICTTHQDPLLSKLKTAPVEPSPERKSLARAIMSEEAVGTEAAAKEPEIETCPSTDPSGDRHEEEPQESSPGCHQMEWQTASPELPGTAGKDHTEELPSSTNATLDLHTQSLETAGSRSGPAAASNACKDSSCVPAPPTEDHCGVARDPKVAPPSESVAEQKLSTGDDGALPGLISEGKYSQAHRKELCLPLQDAFEALPRDQPHSSEVAEPRQPDVTASDGKSAQSQAGLETGPESALCGDRKACDVSTLCLEVCMAPEERRDSEDRVSKETEDYLHSLLERCLKDAEDSLSYEDIQDDDSDLLQDLSPEEASYSLQEDLPPDESTLSLDDLAKKIEIAEAIPAEGLVSILKKRNDTVGSHPAQMQQKPAKRRVRFQEIDDNLEQDEVGGGSCILLILLCIATVFLSVGGTALYCTLGNIESPVCTDFADNVDFYYTKLLQGVAGLKHWVYLS

Q8CBC4-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 128-197: DAVPVMQTQNATSQAAGEEEAAGVNANDPPKAPALQPLFSLIRGEVAQMDSRALPLFLHQVAETYFQEED → EAFRLSLLSFNKNKHFFWCCSAAAPVAPLCGSCIPFVPAVTVYREITTCLVCFLYRPHHGVLTLPSLRHGGFAL
    • 198-711: Missing

Q8CBC4-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence, compositional bias.

Type
IDPosition(s)Description
Alternative sequenceVSP_0386571-289in isoform 3
Compositional bias20-34Basic and acidic residues
Compositional bias57-90Polar residues
Alternative sequenceVSP_025821128-197in isoform 2
Alternative sequenceVSP_025822198-711in isoform 2
Compositional bias312-327Basic and acidic residues
Compositional bias476-490Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK036332
EMBL· GenBank· DDBJ
BAC29388.1
EMBL· GenBank· DDBJ
mRNA
AK040666
EMBL· GenBank· DDBJ
BAC30660.1
EMBL· GenBank· DDBJ
mRNA
AK040899
EMBL· GenBank· DDBJ
BAC30736.1
EMBL· GenBank· DDBJ
mRNA
AK146681
EMBL· GenBank· DDBJ
BAE27356.1
EMBL· GenBank· DDBJ
mRNA
BC034107
EMBL· GenBank· DDBJ
AAH34107.1
EMBL· GenBank· DDBJ
mRNA
BC054802
EMBL· GenBank· DDBJ
AAH54802.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help