Q8CAI9 · Q8CAI9_MOUSE
- ProteinMAP1B protein
- GeneMap1b
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids396 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Publications for Q8CAI9
Gene trap expression and mutational analysis for genes involved in the development of the mammalian nervous system.
- CategoriesSequences, Expression
- SourceMGI: 1306778
The mouse and rat MAP1B genes: genomic organization and alternative transcription.
- CategorySequences
- SourceMGI: 1306778
Otp maps to mouse chromosome 13.
- CategorySequences
- SourceMGI: 1306778
High-resolution linkage map of mouse chromosome 13 in the vicinity of the host resistance locus Lgn1.
- CategorySequences
- SourceMGI: 1306778
Evidence for the stochastic integration of gene trap vectors into the mouse germline.
- CategorySequences
- SourceMGI: 1306778
Isolation and sequencing of the 5' end of the rat microtubule-associated protein (MAP1B)-encoding cDNA.
- CategorySequences
- SourceMGI: 1306778
Neuronal abnormalities in microtubule-associated protein 1B mutant mice.
- CategoryPhenotypes & Variants
- SourceMGI: 1306778
FMRP regulates postnatal neuronal migration via MAP1B.
- AnnotationFMRP regulates postnatal neuronal migration via MAP1B.
- CategoryNames
- SourceGeneRif: 17755
The role of Map1b in regulating osteoblast polarity, proliferation, differentiation and migration.
- AnnotationThe role of Map1b in regulating osteoblast polarity proliferation differentiation and migration.
- CategoryFunction
- SourceGeneRif: 17755
Microtubule-associated protein 1B dysregulates microtubule dynamics and neuronal mitochondrial transport in spinal muscular atrophy.
- AnnotationMicrotubule-associated protein 1B dysregulates microtubule dynamics and neuronal mitochondrial transport in spinal muscular atrophy.
- CategoryFunction
- SourceGeneRif: 17755
FMRP-absence-induced up-regulation of hypothalamic MAP1B expression decreases AgRP level linking with reduces in food intake and body weight.
- AnnotationFMRP-absence-induced up-regulation of hypothalamic MAP1B expression decreases AgRP level linking with reduces in food intake and body weight.
- CategoryFunction
Phosphorylation sites of microtubule-associated protein 1B (MAP 1B) are involved in axon growth and regeneration.
- AnnotationMAP 1B phosphorylation sites are specifically involved in axon growth.
- CategoryPTM / Processing
- SourceGeneRif: 17755
SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes.
- AnnotationThese data provide independent confirmation in a mouse model with combined PARK1/PARK4/PARK6 pathology that MAP1B/ANK2 phosphorylation events are implicated in Parkinsonian neurodegeneration.
- CategoryPTM / Processing
- SourceGeneRif: 17755
Calpain-10 regulates actin dynamics by proteolysis of microtubule- associated protein 1B.
- AnnotationCalpain-10 regulates actin dynamics by proteolysis of microtubule-associated protein 1B
- CategoryFunction
MAP1B mutations cause intellectual disability and extensive white matter deficit.
- AnnotationData show that loss of MAP1B function affects general cognitive ability through a profound brain-wide WM deficit with likely disordered or compromised axons.
- CategoryFunction
- SourceGeneRif: 17755
MAP1B Light Chain Modulates Synaptic Transmission via AMPA Receptor Intracellular Trapping.
- AnnotationMAP1B restricts the access of AMPARs to dendritic spines and the postsynaptic membrane contributing to downregulating synaptic transmission
- CategoryInteraction
Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology.
- AnnotationMAP1B knockout neurons display a decrease in the density of presynaptic and postsynaptic terminals which involves a reduction in the density of synaptic contacts and an increased proportion of orphan presynaptic terminals. MAP1B knockout neurons present altered synaptic vesicle fusion events and a decrease in the density of both synaptic vesicles and dense core vesicles at presynaptic terminals.
- CategoriesFunction, Interaction, Subcellular Location
- SourceGeneRif: 17755