Frizzled 7 modulates goblet and Paneth cell fate, and maintains homeostasis in mouse intestine.Gu N.X., Guo Y.R., Lin S.E., Wang Y.H., Lin I.H., Chen Y.F., Yen Y.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCDevelopment 150:dev200932-dev200932 (2023)Mapped to8
Morphology dynamics in intestinal crypt during postnatal development affect age-dependent susceptibility to radiation-induced intestinal tumorigenesis in ApcMin/+ mice: possible mechanisms of radiation tumorigenesis.Sasatani M., Shimura T., Doi K., Zaharieva E.K., Li J., Iizuka D., Etoh S., Sotomaru Y., Kamiya K.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCCarcinogenesis 44:105-118 (2023)Mapped to16
Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease.Saponara E., Penno C., Orsini V., Wang Z.Y., Fischer A., Aebi A., Matadamas-Guzman M.L., Brun V., Fischer B.[...], Ruffner H.View abstractAnnotationLoss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 14160, MGI: 1341817PubMedEurope PMCAm J Pathol 193:161-181 (2023)Mapped to6
Intestinal Apc-inactivation induces HSP25 dependency.van Neerven S.M., Smit W.L., van Driel M.S., Kakkar V., de Groot N.E., Nijman L.E., Elbers C.C., Leveille N., Heijmans J., Vermeulen L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCEMBO Mol Med 14:e16194-e16194 (2022)Mapped to16
MLL1 is required for maintenance of intestinal stem cells.Goveas N., Waskow C., Arndt K., Heuberger J., Zhang Q., Alexopoulou D., Dahl A., Birchmeier W., Anastassiadis K.[...], Kranz A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCPLoS Genet 17:e1009250-e1009250 (2021)Mapped to11
A tumour-resident Lgr5<sup>+</sup> stem-cell-like pool drives the establishment and progression of advanced gastric cancers.Fatehullah A., Terakado Y., Sagiraju S., Tan T.L., Sheng T., Tan S.H., Murakami K., Swathi Y., Ang N.[...], Barker N.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCNat Cell Biol 23:1299-1313 (2021)Mapped to42
miR-22 promotes stem cell traits via activating Wnt/beta-catenin signaling in cutaneous squamous cell carcinoma.Yuan S., Zhang P., Wen L., Jia S., Wu Y., Zhang Z., Guan L., Yu Z., Zhao L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCOncogene 40:5799-5813 (2021)Mapped to12
High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity.Mana M.D., Hussey A.M., Tzouanas C.N., Imada S., Barrera Millan Y., Bahceci D., Saiz D.R., Webb A.T., Lewis C.A.[...], Yilmaz O.H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCCell Rep 35:109212-109212 (2021)Mapped to31
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.Flanagan D.J., Pentinmikko N., Luopajarvi K., Willis N.J., Gilroy K., Raven A.P., Mcgarry L., Englund J.I., Webb A.T.[...], Sansom O.J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCNature 594:430-435 (2021)Mapped to49
Lgr5 Marks Adult Progenitor Cells Contributing to Skeletal Muscle Regeneration and Sarcoma Formation.Leung C., Murad K.B.A., Tan A.L.T., Yada S., Sagiraju S., Bode P.K., Barker N.View abstractAnnotationLgr5 Marks Adult Progenitor Cells Contributing to Skeletal Muscle Regeneration and Sarcoma Formation.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 14160, MGI: 1341817PubMedEurope PMCCell Rep 33:108535-108535 (2020)Mapped to25
Calorie Restriction Increases the Number of Competing Stem Cells and Decreases Mutation Retention in the Intestine.Bruens L., Ellenbroek S.I.J., Suijkerbuijk S.J.E., Azkanaz M., Hale A.J., Toonen P., Flanagan D.J., Sansom O.J., Snippert H.J., van Rheenen J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCCell Rep 32:107937-107937 (2020)Mapped to16
Hyaluronic acid promotes Lgr5<sup>+</sup> stem cell proliferation and crypt fission through TLR4 and PGE<sub>2</sub> transactivation of EGFR.Riehl T.E., Alvarado D., Ee X., Ciorba M.A., Stenson W.F.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCAm J Physiol Gastrointest Liver Physiol 319:G63-G73 (2020)Mapped to22
Essential role for autophagy protein ATG7 in the maintenance of intestinal stem cell integrity.Trentesaux C., Fraudeau M., Pitasi C.L., Lemarchand J., Jacques S., Duche A., Letourneur F., Naser E., Bailly K.[...], Romagnolo B.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCProc Natl Acad Sci U S A 117:11136-11146 (2020)Mapped to30
MEX3A regulates Lgr5<sup>+</sup> stem cell maintenance in the developing intestinal epithelium.Pereira B., Amaral A.L., Dias A., Mendes N., Muncan V., Silva A.R., Thibert C., Radu A.G., David L.[...], Almeida R.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCEMBO Rep 21:e48938-e48938 (2020)Mapped to7
LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate.Gao Y., Yan Y., Tripathi S., Pentinmikko N., Amaral A., Paivinen P., Domenech-Moreno E., Andersson S., Wong I.P.L.[...], Makela T.P.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCGastroenterology 158:1389-1401.e10 (2020)Mapped to23
Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice.Wang G., Xu J., Zhao J., Yin W., Liu D., Chen W., Hou S.X.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCNat Commun 11:220-220 (2020)Mapped to32
Innate immune receptor NOD2 mediates LGR5+ intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation.Levy A., Stedman A., Deutsch E., Donnadieu F., Virgin H.W., Sansonetti P.J., Nigro G.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 117:1994-2003 (2020)Cited in1Mapped to15
PP2A Deficiency Enhances Carcinogenesis of Lgr5<sup>+</sup> Intestinal Stem Cells Both in Organoids and In Vivo.Yen Y.T., Chien M., Lai Y.C., Chen D.P., Chuong C.M., Hung M.C., Hung S.C.View abstractAnnotationPP2A Deficiency Enhances Carcinogenesis of Lgr5(+) Intestinal Stem Cells Both in Organoids and In Vivo.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 14160, MGI: 1341817PubMedEurope PMCCells 9:E90-E90 (2019)Mapped to10
Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5<sup>-</sup>CD44<sup>+</sup> cells.Fu D.J., Wang L., Chouairi F.K., Rose I.M., Abetov D.A., Miller A.D., Yamulla R.J., Schimenti J.C., Flesken-Nikitin A., Nikitin A.Y.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCNat Commun 11:84-84 (2020)Mapped to49
Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway.He D., Wu H., Xiang J., Ruan X., Peng P., Ruan Y., Chen Y.G., Wang Y., Yu Q.[...], Li B.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCNat Commun 11:37-37 (2020)Mapped to99+
Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glands.Wu L., Belyaeva O.V., Adams M.K., Klyuyeva A.V., Lee S.A., Goggans K.R., Kesterson R.A., Popov K.M., Kedishvili N.Y.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCJ Biol Chem 294:17060-17074 (2019)Mapped to99+
Knockdown of Foxg1 in supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse cochlea.Zhang S., Zhang Y., Dong Y., Guo L., Zhang Z., Shao B., Qi J., Zhou H., Zhu W.[...], Chai R.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCCell Mol Life Sci 77:1401-1419 (2020)Mapped to32
Maternal transmission of an Igf2r domain 11: IGF2 binding mutant allele (Igf2r<sup>I1565A</sup>) results in partial lethality, overgrowth and intestinal adenoma progression.Hughes J., Surakhy M., Can S., Ducker M., Davies N., Szele F., Buhnemann C., Carter E., Trikin R.[...], Hassan A.B.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCSci Rep 9:11388-11388 (2019)Mapped to35
GLI2 Modulated by SUFU and SPOP Induces Intestinal Stem Cell Niche Signals in Development and Tumorigenesis.Coquenlorge S., Yin W.C., Yung T., Pan J., Zhang X., Mo R., Belik J., Hui C.C., Kim T.H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCCell Rep 27:3006-3018.e4 (2019)Mapped to99+
Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer.Gay D.M., Ridgway R.A., Muller M., Hodder M.C., Hedley A., Clark W., Leach J.D., Jackstadt R., Nixon C.[...], Sansom O.J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1341817PubMedEurope PMCNat Commun 10:723-723 (2019)Mapped to31