Q8C5P7 · TDRP_MOUSE

  • Protein
    Testis development-related protein
  • Gene
    Tdrp
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Contributes to normal sperm motility, but not essential for male fertility.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentnucleus
Biological Processspermatogenesis

Names & Taxonomy

Protein names

  • Recommended name
    Testis development-related protein

Gene names

    • Name
      Tdrp

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8C5P7
  • Secondary accessions
    • Q3TQC8

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Cytoplasm
Note: Mainly nuclear. Also detected in cytoplasm near the midpiece of the flagellum.

Keywords

Phenotypes & Variants

Disruption phenotype

Viable with no gross morphological defects. Morphology of testis tissue and mature epididymal sperm is normal. Sperm counts are also normal. Sperm motility is reduced, however this has no significant effect on male fertility.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 12 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00003082201-182
Modified residue7Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Strongly expressed in testis. Also detected at lower levels in epididymis, bone marrow and kidney.

Gene expression databases

Interaction

Subunit

Interacts with PRM2.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-38Disordered
Region52-73Disordered
Region95-151Disordered
Compositional bias112-129Basic and acidic residues
Compositional bias137-151Polar residues

Sequence similarities

Belongs to the TDRP family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q8C5P7-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    182
  • Mass (Da)
    20,186
  • Last updated
    2003-03-01 v1
  • Checksum
    375805676B69D899
MWKLSRSRVLLDEPPEEEDVLRGAPPASAAAPASGASLRGWKEATSLFNKDDEEHLLETSRSPKSKGTNQRLREELKAEKKSGFWDALVLKQNAQPKKPDQIEGWEPPKLTAEDVVADHTEDDRSGCPPWSAWEDDTKGSTKYTSLANSASSSRWSLRSAGKLVSIRRQSKGHLTETCEEGE

Q8C5P7-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 34-182: SGASLRGWKEATSLFNKDDEEHLLETSRSPKSKGTNQRLREELKAEKKSGFWDALVLKQNAQPKKPDQIEGWEPPKLTAEDVVADHTEDDRSGCPPWSAWEDDTKGSTKYTSLANSASSSRWSLRSAGKLVSIRRQSKGHLTETCEEGE → SVRARVGAQVRAAGCSGGRAQVHGVACRVRTWQGPDASRGCEVTAPEDPSDEWPGPTGRGPQSQHVWGTAGTRTPGTFRTGRRRCPSLCCHKGFGVRLETPGTRGDRFQARYFYSGVGETEKS

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
D3YVM3D3YVM3_MOUSETdrp74
A0A1B0GRY6A0A1B0GRY6_MOUSETdrp35

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_02892434-182in isoform 2
Compositional bias112-129Basic and acidic residues
Compositional bias137-151Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK077810
EMBL· GenBank· DDBJ
BAC37021.1
EMBL· GenBank· DDBJ
mRNA
AK163687
EMBL· GenBank· DDBJ
BAE37456.1
EMBL· GenBank· DDBJ
mRNA
AK166875
EMBL· GenBank· DDBJ
BAE39086.1
EMBL· GenBank· DDBJ
mRNA
AK166972
EMBL· GenBank· DDBJ
BAE39155.1
EMBL· GenBank· DDBJ
mRNA
BC099613
EMBL· GenBank· DDBJ
AAH99613.1
EMBL· GenBank· DDBJ
mRNA
BC132465
EMBL· GenBank· DDBJ
AAI32466.1
EMBL· GenBank· DDBJ
mRNA
BC132467
EMBL· GenBank· DDBJ
AAI32468.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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