Q8C2T4 · Q8C2T4_MOUSE
- ProteinZinc transporter
- GeneSlc30a5
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids633 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Functions as a zinc transporter.
Catalytic activity
- 2 H+(out) + Zn2+(in) = 2 H+(in) + Zn2+(out)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | ER to Golgi transport vesicle membrane | |
Cellular Component | Golgi cisterna membrane | |
Molecular Function | metal ion binding | |
Molecular Function | zinc ion transmembrane transporter activity | |
Biological Process | intracellular zinc ion homeostasis |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameZinc transporter
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8C2T4
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cytoplasmic vesicle, COPII-coated vesicle membrane ; Multi-pass membrane protein
Cytoplasmic vesicle, secretory vesicle membrane ; Multi-pass membrane protein
Golgi apparatus, Golgi stack membrane ; Multi-pass membrane protein
Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 22-42 | Helical | ||||
Sequence: IFKHAVAGCIISLLWFFGLTL | ||||||
Transmembrane | 49-69 | Helical | ||||
Sequence: LLLFEHSDIVVISLLSVLFTS | ||||||
Transmembrane | 75-93 | Helical | ||||
Sequence: AKTRGAAFFIIAVICLLLF | ||||||
Transmembrane | 136-154 | Helical | ||||
Sequence: SWFSLIMPFTTVIFFVMIL | ||||||
Transmembrane | 174-192 | Helical | ||||
Sequence: YGSFPIFISALLFGNFWTH | ||||||
Transmembrane | 212-232 | Helical | ||||
Sequence: HVLSGGVVVSAVFFILSANIL | ||||||
Transmembrane | 289-308 | Helical | ||||
Sequence: IFYFLCLNLLFTFVELFYGV | ||||||
Transmembrane | 320-338 | Helical | ||||
Sequence: FHMLFDCSALVMGLFAALM | ||||||
Transmembrane | 359-379 | Helical | ||||
Sequence: GFINGLFLIVIAFFVFMESVA | ||||||
Transmembrane | 391-410 | Helical | ||||
Sequence: MLTPVSVGGLIVNLIGICAF | ||||||
Transmembrane | 460-481 | Helical | ||||
Sequence: VFLHVLADTLGSIGVIVSTVLI | ||||||
Transmembrane | 487-509 | Helical | ||||
Sequence: FIADPLCSLFIAVLIFLSVIPLI |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Interaction
Subunit
Heterodimer with SLC30A6/ZNT6; form a functional zinc ion transmembrane transporter.
Homooligomer.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 421-448 | Disordered | ||||
Sequence: SQGNCHSDHGHSHHAHGHGHDHGHSHGF |
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length633
- Mass (Da)70,056
- Last updated2003-03-01 v1
- Checksum2013C8450DE0D668