Identification of two distinct functions for TGF-beta in early mouse development.Roelen B.A., Goumans M.J., Zwijsen A., Mummery C.L.View abstractCategoriesSequencesSourceMGI: 108051PubMedEurope PMCDifferentiation 64:19-31 (1998)Mapped to36
FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals.Liu B., Dou C.-L., Prabhu L., Lai E.View abstractCategoriesSequencesSourceMGI: 108051PubMedEurope PMCMol. Cell. Biol. 19:424-430 (1999)Cited in1Mapped to26
Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2.Labbe E., Silvestri C., Hoodless P.A., Wrana J.L., Attisano L.View abstractCategoriesFunctionSourceMGI: 108051PubMedEurope PMCMol. Cell 2:109-120 (1998)Cited in1Mapped to23
Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2.Weinstein M., Yang X., Li C., Xu X., Gotay J., Deng C.X.View abstractCategoriesFunctionSourceMGI: 108051PubMedEurope PMCProc Natl Acad Sci U S A 95:9378-9383 (1998)Mapped to27
Smad2 role in mesoderm formation, left-right patterning and craniofacial development.Nomura M., Li E.View abstractCategoriesFunctionSourceMGI: 108051PubMedEurope PMCNature 393:786-790 (1998)Mapped to12
Expression of Smad1 and Smad2 during embryogenesis suggests a role in organ development.Dick A., Risau W., Drexler H.View abstractCategoriesSequences, ExpressionSourceMGI: 108051PubMedEurope PMCDev Dyn 211:293-305 (1998)Mapped to8
Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo.Waldrip W.R., Bikoff E.K., Hoodless P.A., Wrana J.L., Robertson E.J.View abstractCategoriesFunctionSourceMGI: 108051PubMedEurope PMCCell 92:797-808 (1998)Mapped to47
Smad4 (homolog of human DPC4) and Smad2 (homolog of human JV18-1): candidates for murine lung tumor resistance and suppressor genes.Devereux T.R., Anna C.H., Patel A.C., White C.M., Festing M.F., You M.View abstractCategoriesSequencesSourceMGI: 108051PubMedEurope PMCCarcinogenesis 18:1751-1755 (1997)Cited in1Mapped to10
Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins.Chen Y., Lebrun J.-J., Vale W.W.View abstractCategoriesSequencesSourceMGI: 108051PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 93:12992-12997 (1996)Cited in2Mapped to6
A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.Baker J.C., Harland R.M.View abstractCategoriesSubcellular LocationSourceMGI: 108051PubMedEurope PMCGenes Dev. 10:1880-1889 (1996)Cited in1Mapped to5
Progenitor-like cells contributing to cellular heterogeneity in the nucleus pulposus are lost in intervertebral disc degeneration.Tan Z., Chen P., Dong X., Guo S., Leung V.Y.L., Cheung J.P.Y., Chan D., Richardson S.M., Hoyland J.A.[...], Cheah K.S.E.View abstractSourceMGI: 108051PubMedEurope PMCCell Rep 43:114342-114342 (2024)Mapped to86
Thbs1 regulates skeletal muscle mass in a TGFbeta-Smad2/3-ATF4-dependent manner.Vanhoutte D., Schips T.G., Minerath R.A., Huo J., Kavuri N.S.S., Prasad V., Lin S.C., Bround M.J., Sargent M.A.[...], Molkentin J.D.View abstractAnnotationThbs1 regulates skeletal muscle mass in a TGFbeta-Smad2/3-ATF4-dependent manner.CategoriesFunctionSourceGeneRif: 17126, MGI: 108051PubMedEurope PMCCell Rep 43:114149-114149 (2024)Mapped to62
Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure.Dali O., D'Cruz S., Legoff L., Diba Lahmidi M., Heitz C., Merret P.E., Kernanec P.Y., Pakdel F., Smagulova F.View abstractCategoriesFunctionSourceMGI: 108051PubMedEurope PMCLife Sci Alliance 7:e202302237-e202302237 (2024)Mapped to99+
Impact of <i>SMAD2</i> and <i>MET</i> Expression on Lymph Node Metastasis of HER2-positive Gastric Cancer Cells.Tsujio G., Yashiro M., Sakuma T., Aoyama R., Maruo K., Yamamoto Y., Maeda K.View abstractAnnotationImpact of SMAD2 and MET Expression on Lymph Node Metastasis of HER2-positive Gastric Cancer Cells.CategoriesFunctionSourceGeneRif: 17126PubMedEurope PMCAnticancer Res 43:4359-4364 (2023)Mapped to10
APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFbeta-mediated checkpoints.Yin Z., Rosenzweig N., Kleemann K.L., Zhang X., Brandao W., Margeta M.A., Schroeder C., Sivanathan K.N., Silveira S.[...], Butovsky O.View abstractSourceMGI: 108051PubMedEurope PMCNat Immunol 24:1839-1853 (2023)Mapped to55
The projection-specific signals that establish functionally segregated dopaminergic synapses.Terauchi A., Yee P., Johnson-Venkatesh E.M., Seiglie M.P., Kim L., Pitino J.C., Kritzer E., Zhang Q., Zhou J.[...], Umemori H.View abstractCategoriesFunctionSourceMGI: 108051PubMedEurope PMCCell 186:3845-3861.e24 (2023)Mapped to8
Activin A/ACVR2A axis inhibits epithelial-to-mesenchymal transition in colon cancer by activating SMAD2.Zhang H., Ruan Q., Chen C., Yu H., Guan S., Hu D., Yang C., Lin R., Zhuo C.View abstractAnnotationActivin A/ACVR2A axis inhibits epithelial-to-mesenchymal transition in colon cancer by activating SMAD2.CategoriesFunctionSourceGeneRif: 17126PubMedEurope PMCMol Carcinog 62:1585-1598 (2023)Mapped to11
Topologically associating domain boundaries are required for normal genome function.Rajderkar S., Barozzi I., Zhu Y., Hu R., Zhang Y., Li B., Alcaina Caro A., Fukuda-Yuzawa Y., Kelman G.[...], Pennacchio L.A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 108051PubMedEurope PMCCommun Biol 6:435-435 (2023)Mapped to59
TGF-beta signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development.Feng J., Han X., Yuan Y., Cho C.K., Janeckova E., Guo T., Pareek S., Rahman M.S., Zheng B.[...], Chai Y.View abstractCategoriesFunctionSourceMGI: 108051PubMedEurope PMCElife 11:e80405-e80405 (2022)Mapped to99+
Mitochondrial dysfunction induces ALK5-SMAD2-mediated hypovascularization and arteriovenous malformations in mouse retinas.Zhang H., Li B., Huang Q., Lopez-Giraldez F., Tanaka Y., Lin Q., Mehta S., Wang G., Graham M.[...], Zhou J.H.View abstractAnnotationMitochondrial dysfunction induces ALK5-SMAD2-mediated hypovascularization and arteriovenous malformations in mouse retinas.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 17126, MGI: 108051PubMedEurope PMCNat Commun 13:7637-7637 (2022)Mapped to27
ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis.Kumar S., Fan X., Rasouly H.M., Sharma R., Salant D.J., Lu W.View abstractCategoriesFunctionSourceMGI: 108051PubMedEurope PMCJCI Insight 8:e158418-e158418 (2023)Mapped to99+
Creb5 coordinates synovial joint formation with the genesis of articular cartilage.Zhang C.H., Gao Y., Hung H.H., Zhuo Z., Grodzinsky A.J., Lassar A.B.View abstractCategoriesFunctionSourceMGI: 108051PubMedEurope PMCNat Commun 13:7295-7295 (2022)Mapped to84
Maternal immune activation leads to defective brain-blood vessels and intracerebral hemorrhages in male offspring.Rasile M., Lauranzano E., Faggiani E., Ravanelli M.M., Colombo F.S., Mirabella F., Corradini I., Malosio M.L., Borreca A.[...], Matteoli M.View abstractCategoriesFunctionSourceMGI: 108051PubMedEurope PMCEMBO J 41:e111192-e111192 (2022)Mapped to96
The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFbeta signaling pathways to drive tongue organogenesis.Xu J., Liu H., Lan Y., Jiang R.View abstractCategoriesFunctionSourceMGI: 108051PubMedEurope PMCDevelopment 149:dev200667-dev200667 (2022)Mapped to84
Lack of extracellular matrix switches TGF-beta induced apoptosis of endometrial cells to epithelial to mesenchymal transition.Ruiz-Mitjana A., Navaridas R., Vidal-Sabanes M., Perramon-Guell A., Yeramian A., Felip I., Eritja N., Egea J., Encinas M.[...], Dolcet X.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 108051PubMedEurope PMCSci Rep 12:14821-14821 (2022)Mapped to12