Q8C140 · Q8C140_MOUSE
- ProteinEF-hand domain-containing protein
- GeneSlc25a13
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids675 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation.
Catalytic activity
- 3-sulfino-L-alanine(out) + L-glutamate(in) + H+(in) = 3-sulfino-L-alanine(in) + L-glutamate(out) + H+(out)3-sulfino-L-alanine (out)CHEBI:61085
+ L-glutamate (in)CHEBI:29985+ H+ (in)CHEBI:15378= 3-sulfino-L-alanine (in)CHEBI:61085+ L-glutamate (out)CHEBI:29985+ H+ (out)CHEBI:15378 - 3-sulfino-L-alanine(out) + L-aspartate(in) = 3-sulfino-L-alanine(in) + L-aspartate(out)
- L-aspartate(in) + L-glutamate(out) + H+(out) = L-aspartate(out) + L-glutamate(in) + H+(in)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | calcium ion binding | |
Biological Process | malate-aspartate shuttle |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameEF-hand domain-containing protein
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8C140
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Interaction
Subunit
Homodimer (via N-terminus).
Structure
Family & Domains
Features
Showing features for domain, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 87-122 | EF-hand | ||||
Sequence: APDALFMVAFQLFDKAGKGEVTFEDVKQIFGQTTIH | ||||||
Domain | 158-193 | EF-hand | ||||
Sequence: IQLEHAKQAFVQRDNAKTGKVSAIDFRDIMVTIRPH | ||||||
Repeat | 326-418 | Solcar | ||||
Sequence: AESAYRFGLGSIAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDK | ||||||
Repeat | 426-510 | Solcar | ||||
Sequence: VPLLAEIFAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKAS | ||||||
Repeat | 518-606 | Solcar | ||||
Sequence: VSPGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYNGVTDCFRKILREEGPKALWKGVAARVFRSSPQFGVTLLTYELLQRW |
Sequence similarities
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length675
- Mass (Da)74,339
- Last updated2003-03-01 v1
- Checksum4BBA8BB5D7BA7A11
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK029020 EMBL· GenBank· DDBJ | BAC26247.1 EMBL· GenBank· DDBJ | mRNA |