Q8C110 · SLIK6_MOUSE
- ProteinSLIT and NTRK-like protein 6
- GeneSlitrk6
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids840 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Regulator of neurite outgrowth required for normal hearing and vision.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell periphery | |
Cellular Component | cell surface | |
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Biological Process | adult locomotory behavior | |
Biological Process | auditory behavior | |
Biological Process | auditory receptor cell morphogenesis | |
Biological Process | axonogenesis | |
Biological Process | camera-type eye development | |
Biological Process | cochlea development | |
Biological Process | inner ear morphogenesis | |
Biological Process | innervation | |
Biological Process | lens development in camera-type eye | |
Biological Process | linear vestibuloocular reflex | |
Biological Process | multicellular organism growth | |
Biological Process | neuron projection morphogenesis | |
Biological Process | positive regulation of synapse assembly | |
Biological Process | regulation of presynapse assembly | |
Biological Process | sensory perception of sound | |
Biological Process | startle response | |
Biological Process | synapse assembly | |
Biological Process | vestibular reflex | |
Biological Process | vestibulocochlear nerve development | |
Biological Process | visual perception |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSLIT and NTRK-like protein 6
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8C110
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 23-609 | Extracellular | ||||
Sequence: PMPSVRGSCDTLCNCEEKDGIMIINCEEKGINKLSQISVPPSRPFHLSLLNNGLTMLHTNDFSGLTNALSIHLGFNNIADIETGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITIIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCELLQLKNWLENMPPQSIIGDVICYSPPPFKGSVLSRLKKESFCPTPPVYEEHEDPSGSLLAITSSTSDSRLSSKNTSILKQPTKAPGLIPYLTKPSTQLPVPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLQPPPHNPRKLILAGNIIHTLMKSDLTDYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLNKGMFLGLHSLEYLYLEYNAVKEILPGTFNPMPKLKVLYLNNNLLQVLPAHIFLGIPLTRVNLKTNQFTHLPVSNILDDLDFLIQIDLEDNPWDCSCDLVGLQQWIHKLGKGTMTDDILCTSPGHLDKKELKALNSDLLCPGLVNNPSMPTQTTYVIVTSPTVAADTASTLFSSLTDAVPLSVL | ||||||
Transmembrane | 610-630 | Helical | ||||
Sequence: ILGLLIVFITIVFCAAGIVVF | ||||||
Topological domain | 631-840 | Cytoplasmic | ||||
Sequence: VLHRRRRYKKKKVEEQLRDNSPVHLQYSMYGHKTTHHTTERPSSSLYEQHMVSPMVHVYRSPSFGPKHLEEVEERNDKEGNDAKHLQRSLLERENHSPLTGSNMKYKTTDQSTDFISFQDASLLYRNILEKERELQQLGITEYLRKNLAQLQPEVEVNYPGAHEELKLMETLMYSRPRKVLVEQTKNEYFELKANLHAEPDYLEVLEQQT |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Male and female mice grow without showing any external abnormalities and are fertile but display auditory deficits. In the developing inner ear, mice show pronounced reduction of cochlear innervation, despite normal gross morphology and general organization of the organ of Corti (PubMed:19936227).
Adult mice have reduced startle response and impaired auditory brainstem responses consistent with mid-frequency range hearing loss (PubMed:21298075).
Retinas in postnatal development display a delay in synaptogenesis (PubMed:23543054).
Adult mice have reduced startle response and impaired auditory brainstem responses consistent with mid-frequency range hearing loss (PubMed:21298075).
Retinas in postnatal development display a delay in synaptogenesis (PubMed:23543054).
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 36 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MKLWTYLLYPSLLACLSL | ||||||
Chain | PRO_0000032684 | 19-840 | SLIT and NTRK-like protein 6 | |||
Sequence: QSQSPMPSVRGSCDTLCNCEEKDGIMIINCEEKGINKLSQISVPPSRPFHLSLLNNGLTMLHTNDFSGLTNALSIHLGFNNIADIETGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITIIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCELLQLKNWLENMPPQSIIGDVICYSPPPFKGSVLSRLKKESFCPTPPVYEEHEDPSGSLLAITSSTSDSRLSSKNTSILKQPTKAPGLIPYLTKPSTQLPVPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLQPPPHNPRKLILAGNIIHTLMKSDLTDYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLNKGMFLGLHSLEYLYLEYNAVKEILPGTFNPMPKLKVLYLNNNLLQVLPAHIFLGIPLTRVNLKTNQFTHLPVSNILDDLDFLIQIDLEDNPWDCSCDLVGLQQWIHKLGKGTMTDDILCTSPGHLDKKELKALNSDLLCPGLVNNPSMPTQTTYVIVTSPTVAADTASTLFSSLTDAVPLSVLILGLLIVFITIVFCAAGIVVFVLHRRRRYKKKKVEEQLRDNSPVHLQYSMYGHKTTHHTTERPSSSLYEQHMVSPMVHVYRSPSFGPKHLEEVEERNDKEGNDAKHLQRSLLERENHSPLTGSNMKYKTTDQSTDFISFQDASLLYRNILEKERELQQLGITEYLRKNLAQLQPEVEVNYPGAHEELKLMETLMYSRPRKVLVEQTKNEYFELKANLHAEPDYLEVLEQQT |
Proteomic databases
PTM databases
Expression
Tissue specificity
In the embryo, expressed in otic cyst, lateral trunk epidermis and underlying mesodermal tissue, limb bud, maxillary process, cochlea, retina, tongue, tooth primordium, central nervous system, and primordia of visceral organs including lung, gastrointestinal tract and pancreas. In the central nervous system, expressed primarily in dorsal thalamus, cerebellum and medulla.
Developmental stage
During inner ear development, detected early in the otic vesicle, and later in cochlear and vestibular sensory epithelia. Present in the presumptive organ of Corti by 14.5 dpc, and then confined to the supporting cell types at later stages of embryonic development and at the newborn. In the vestibular sensory epithelia, present at the lumenal surface. However, it is detected in the non-hair cell region, presumably in the lumenal processes of the supporting cells. Transiently expressed in the spiral and vestibular ganglion neurons (at protein level) (PubMed:19936227).
First expressed at 8.5 dpc. In the newborn, broadly detected in neural retina. Later, in P10 retina, expression is enhanced in the inner nuclear and outer plexiform layers. Expression in retina decreases as development proceeded, and is detected in the inner nuclear layer and in a subset of cells in the ganglion cell layer of adults (PubMed:23543054).
First expressed at 8.5 dpc. In the newborn, broadly detected in neural retina. Later, in P10 retina, expression is enhanced in the inner nuclear and outer plexiform layers. Expression in retina decreases as development proceeded, and is detected in the inner nuclear layer and in a subset of cells in the ganglion cell layer of adults (PubMed:23543054).
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, repeat, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 22-67 | LRRNT 1 | ||||
Sequence: SPMPSVRGSCDTLCNCEEKDGIMIINCEEKGINKLSQISVPPSRPF | ||||||
Repeat | 89-110 | LRR 1 | ||||
Sequence: NALSIHLGFNNIADIETGAFNG | ||||||
Repeat | 113-134 | LRR 2 | ||||
Sequence: LLKQLHINHNSLEILKEDTFHG | ||||||
Repeat | 137-158 | LRR 3 | ||||
Sequence: NLEFLQADNNFITIIEPSAFSK | ||||||
Repeat | 161-182 | LRR 4 | ||||
Sequence: RLKVLILNDNAIESLPPNIFRF | ||||||
Repeat | 184-205 | LRR 5 | ||||
Sequence: PLTHLDLRGNQLQTLPYVGFLE | ||||||
Domain | 218-269 | LRRCT 1 | ||||
Sequence: NKWACNCELLQLKNWLENMPPQSIIGDVICYSPPPFKGSVLSRLKKESFCPT | ||||||
Domain | 319-360 | LRRNT 2 | ||||
Sequence: PSTQLPVPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLQPP | ||||||
Repeat | 363-384 | LRR 6 | ||||
Sequence: NPRKLILAGNIIHTLMKSDLTD | ||||||
Repeat | 387-408 | LRR 7 | ||||
Sequence: TLEMLHLGNNRIEVLEEGSFMN | ||||||
Repeat | 411-432 | LRR 8 | ||||
Sequence: RLQKLYLNGNHLTKLNKGMFLG | ||||||
Repeat | 435-456 | LRR 9 | ||||
Sequence: SLEYLYLEYNAVKEILPGTFNP | ||||||
Repeat | 459-480 | LRR 10 | ||||
Sequence: KLKVLYLNNNLLQVLPAHIFLG | ||||||
Repeat | 482-503 | LRR 11 | ||||
Sequence: PLTRVNLKTNQFTHLPVSNILD | ||||||
Domain | 516-567 | LRRCT 2 | ||||
Sequence: NPWDCSCDLVGLQQWIHKLGKGTMTDDILCTSPGHLDKKELKALNSDLLCPG | ||||||
Region | 717-736 | Disordered | ||||
Sequence: QRSLLERENHSPLTGSNMKY |
Sequence similarities
Belongs to the SLITRK family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length840
- Mass (Da)95,056
- Last updated2003-03-01 v1
- Checksum9D812FADCFF43097
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB097575 EMBL· GenBank· DDBJ | BAC67209.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK029275 EMBL· GenBank· DDBJ | BAC26368.1 EMBL· GenBank· DDBJ | mRNA |