Q8C0X2 · SL9B1_MOUSE

  • Protein
    Sodium/hydrogen exchanger 9B1
  • Gene
    Slc9b1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Sperm-specific Na+/H+ exchanger involved in intracellular pH regulation of spermatozoa (PubMed:20036903).
Involved in sperm motility and fertility (PubMed:19409551, PubMed:20036903, PubMed:27010853).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Cellular Componentsperm principal piece
Molecular Functionantiporter activity
Biological Processflagellated sperm motility
Biological Processinorganic cation transmembrane transport
Biological Processproton transmembrane transport
Biological Processregulation of intracellular pH
Biological Processsingle fertilization
Biological Processsodium ion transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sodium/hydrogen exchanger 9B1
  • Alternative names
    • Na(+)/H(+) exchanger-like domain-containing protein 1 (NHE domain-containing protein 1)
    • Sodium/hydrogen exchanger-like domain-containing protein 1
    • Solute carrier family 9 subfamily B member 1
    • Testis specific sodium-hydrogen exchanger
      (MtsNHE
      )

Gene names

    • Name
      Slc9b1
    • Synonyms
      Nha1
      , Nhedc1

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • Czech II
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8C0X2
  • Secondary accessions
    • B5AFL0
    • Q8C1I8
    • Q8R3N0
    • Q9CPR9
    • Q9D400

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane122-142Helical
Transmembrane146-166Helical
Transmembrane167-187Helical
Transmembrane206-223Helical
Transmembrane238-258Helical
Transmembrane266-286Helical
Transmembrane311-331Helical
Transmembrane341-361Helical
Transmembrane371-391Helical
Transmembrane419-439Helical
Transmembrane449-469Helical
Transmembrane482-502Helical
Transmembrane523-543Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Mice are normal but males shown reduced fertility caused by diminished sperm motility (PubMed:27010853).
Addition of cAMP analogs almost completely rescue the motility and infertility phenotypes in vitro (PubMed:27010853).
Double knockout of SLC9B1 and SLC9B2 results in male infertility with a severe sperm mobility reduction, indicating that these two gene are functionally redundant (PubMed:27010853).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003140091-565Sodium/hydrogen exchanger 9B1

Proteomic databases

PTM databases

Expression

Tissue specificity

Testis-specific (PubMed:20036903).
Expressed in the spermatids and spermatozoa (at protein level) (PubMed:20036903).
Specifically present in the principal piece of sperm tail (at protein level) (PubMed:19409551, PubMed:20036903, PubMed:27010853).

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-112Disordered
Compositional bias25-104Basic and acidic residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (5)
  • Sequence status
    Complete

This entry describes 5 isoforms produced by Alternative splicing.

Q8C0X2-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    565
  • Mass (Da)
    61,958
  • Last updated
    2003-03-01 v1
  • Checksum
    7ECBC2E03DC90655
MSEHDVESNKKDDGFQSSVTVEMSKDPDSFHEETVEPKPELKEPEPKEPEPKEPERKEPERKEPERKEPERKEPERKVPGRRETQTKETQTTEIERKETKKKRGTNSYCPPQGTINKTITDGAALIALWTLLWALIGQEVLPGGNLFGLVVIFYSAFLGGKILEFIKIPVVPPLPPLIGMLLAGFTIRNVPIIYEFVHIPTTWSSALRNTALTIILVRAGLGLDPQALKHLKGVCLRLSFGPCFLEACSAALFSHFIMNFPWQWGFLLGFVLGAVSPAVVVPNMLMLQENGYGVEKGIPTLLVAASSMDDIVAITGFNTFLSIVFSSGSVISNILSSLRDVLIGVLVGIVMGVFVQYFPSGDQERLTQRRAFLVLSMCISAVLGCQHIGLHGSGGLVTLVLSFMAAKRWAEEKVGIQKIVANTWNVFQPLLFGLVGTEVSVESLESKTIGMCLATLGLALSVRILSTFVLMSFANFRFKEKVFIALSWIPKATVQAVLGPLALETARVMAPHLEGYAKAVMTVAFLAILITAPNGALLIGILGPKILEQSEVTFPLKVELSNFHH

Q8C0X2-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q8C0X2-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q8C0X2-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 123-145: AALIALWTLLWALIGQEVLPGGN → MSNKKCTWGENEKYKMQMIRLTV
    • 146-565: Missing

Q8C0X2-5

  • Name
    5
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 77-114: KVPGRRETQTKETQTTEIERKETKKKRGTNSYCPPQGT → SCTHCTMDSTLGPYRSRSSPWWKFVWTCSYFLQCFPWG
    • 115-565: Missing

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
G5E8I2G5E8I2_MOUSESlc9b1565
F7CTY9F7CTY9_MOUSESlc9b188
E0CY67E0CY67_MOUSESlc9b1144

Features

Showing features for compositional bias, alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Compositional bias25-104Basic and acidic residues
Alternative sequenceVSP_03018177-114in isoform 5
Alternative sequenceVSP_030182115-565in isoform 5
Alternative sequenceVSP_030183123-145in isoform 4
Alternative sequenceVSP_030184146-565in isoform 4
Sequence conflict167in Ref. 2; BAB30495 and 3; AAH25002
Sequence conflict263in Ref. 2; BAC25498
Alternative sequenceVSP_030185270-565in isoform 3
Alternative sequenceVSP_030186364-378in isoform 2
Alternative sequenceVSP_030187379-565in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU846100
EMBL· GenBank· DDBJ
ACF60498.1
EMBL· GenBank· DDBJ
mRNA
AK007064
EMBL· GenBank· DDBJ
BAB24849.1
EMBL· GenBank· DDBJ
mRNA
AK015318
EMBL· GenBank· DDBJ
BAB29794.1
EMBL· GenBank· DDBJ
mRNA
AK016883
EMBL· GenBank· DDBJ
BAC25498.1
EMBL· GenBank· DDBJ
mRNA
AK016917
EMBL· GenBank· DDBJ
BAB30495.1
EMBL· GenBank· DDBJ
mRNA
AK029525
EMBL· GenBank· DDBJ
BAC26494.1
EMBL· GenBank· DDBJ
mRNA
BC025002
EMBL· GenBank· DDBJ
AAH25002.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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