Q8C0X2 · SL9B1_MOUSE
- ProteinSodium/hydrogen exchanger 9B1
- GeneSlc9b1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids565 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Sperm-specific Na+/H+ exchanger involved in intracellular pH regulation of spermatozoa (PubMed:20036903).
Involved in sperm motility and fertility (PubMed:19409551, PubMed:20036903, PubMed:27010853).
Involved in sperm motility and fertility (PubMed:19409551, PubMed:20036903, PubMed:27010853).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | sperm principal piece | |
Molecular Function | antiporter activity | |
Biological Process | flagellated sperm motility | |
Biological Process | inorganic cation transmembrane transport | |
Biological Process | proton transmembrane transport | |
Biological Process | regulation of intracellular pH | |
Biological Process | single fertilization | |
Biological Process | sodium ion transport |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSodium/hydrogen exchanger 9B1
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8C0X2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell projection, cilium, flagellum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 122-142 | Helical | ||||
Sequence: GAALIALWTLLWALIGQEVLP | ||||||
Transmembrane | 146-166 | Helical | ||||
Sequence: LFGLVVIFYSAFLGGKILEFI | ||||||
Transmembrane | 167-187 | Helical | ||||
Sequence: KIPVVPPLPPLIGMLLAGFTI | ||||||
Transmembrane | 206-223 | Helical | ||||
Sequence: ALRNTALTIILVRAGLGL | ||||||
Transmembrane | 238-258 | Helical | ||||
Sequence: LSFGPCFLEACSAALFSHFIM | ||||||
Transmembrane | 266-286 | Helical | ||||
Sequence: FLLGFVLGAVSPAVVVPNMLM | ||||||
Transmembrane | 311-331 | Helical | ||||
Sequence: IVAITGFNTFLSIVFSSGSVI | ||||||
Transmembrane | 341-361 | Helical | ||||
Sequence: VLIGVLVGIVMGVFVQYFPSG | ||||||
Transmembrane | 371-391 | Helical | ||||
Sequence: AFLVLSMCISAVLGCQHIGLH | ||||||
Transmembrane | 419-439 | Helical | ||||
Sequence: IVANTWNVFQPLLFGLVGTEV | ||||||
Transmembrane | 449-469 | Helical | ||||
Sequence: IGMCLATLGLALSVRILSTFV | ||||||
Transmembrane | 482-502 | Helical | ||||
Sequence: VFIALSWIPKATVQAVLGPLA | ||||||
Transmembrane | 523-543 | Helical | ||||
Sequence: VAFLAILITAPNGALLIGILG |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Mice are normal but males shown reduced fertility caused by diminished sperm motility (PubMed:27010853).
Addition of cAMP analogs almost completely rescue the motility and infertility phenotypes in vitro (PubMed:27010853).
Double knockout of SLC9B1 and SLC9B2 results in male infertility with a severe sperm mobility reduction, indicating that these two gene are functionally redundant (PubMed:27010853).
Addition of cAMP analogs almost completely rescue the motility and infertility phenotypes in vitro (PubMed:27010853).
Double knockout of SLC9B1 and SLC9B2 results in male infertility with a severe sperm mobility reduction, indicating that these two gene are functionally redundant (PubMed:27010853).
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000314009 | 1-565 | Sodium/hydrogen exchanger 9B1 | |||
Sequence: MSEHDVESNKKDDGFQSSVTVEMSKDPDSFHEETVEPKPELKEPEPKEPEPKEPERKEPERKEPERKEPERKEPERKVPGRRETQTKETQTTEIERKETKKKRGTNSYCPPQGTINKTITDGAALIALWTLLWALIGQEVLPGGNLFGLVVIFYSAFLGGKILEFIKIPVVPPLPPLIGMLLAGFTIRNVPIIYEFVHIPTTWSSALRNTALTIILVRAGLGLDPQALKHLKGVCLRLSFGPCFLEACSAALFSHFIMNFPWQWGFLLGFVLGAVSPAVVVPNMLMLQENGYGVEKGIPTLLVAASSMDDIVAITGFNTFLSIVFSSGSVISNILSSLRDVLIGVLVGIVMGVFVQYFPSGDQERLTQRRAFLVLSMCISAVLGCQHIGLHGSGGLVTLVLSFMAAKRWAEEKVGIQKIVANTWNVFQPLLFGLVGTEVSVESLESKTIGMCLATLGLALSVRILSTFVLMSFANFRFKEKVFIALSWIPKATVQAVLGPLALETARVMAPHLEGYAKAVMTVAFLAILITAPNGALLIGILGPKILEQSEVTFPLKVELSNFHH |
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-112 | Disordered | ||||
Sequence: MSEHDVESNKKDDGFQSSVTVEMSKDPDSFHEETVEPKPELKEPEPKEPEPKEPERKEPERKEPERKEPERKEPERKVPGRRETQTKETQTTEIERKETKKKRGTNSYCPPQ | ||||||
Compositional bias | 25-104 | Basic and acidic residues | ||||
Sequence: KDPDSFHEETVEPKPELKEPEPKEPEPKEPERKEPERKEPERKEPERKEPERKVPGRRETQTKETQTTEIERKETKKKRG |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 5 isoforms produced by Alternative splicing.
Q8C0X2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length565
- Mass (Da)61,958
- Last updated2003-03-01 v1
- Checksum7ECBC2E03DC90655
Q8C0X2-2
- Name2
Q8C0X2-3
- Name3
- Differences from canonical
- 270-565: Missing
Q8C0X2-4
- Name4
Q8C0X2-5
- Name5
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Features
Showing features for compositional bias, alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 25-104 | Basic and acidic residues | ||||
Sequence: KDPDSFHEETVEPKPELKEPEPKEPEPKEPERKEPERKEPERKEPERKEPERKVPGRRETQTKETQTTEIERKETKKKRG | ||||||
Alternative sequence | VSP_030181 | 77-114 | in isoform 5 | |||
Sequence: KVPGRRETQTKETQTTEIERKETKKKRGTNSYCPPQGT → SCTHCTMDSTLGPYRSRSSPWWKFVWTCSYFLQCFPWG | ||||||
Alternative sequence | VSP_030182 | 115-565 | in isoform 5 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_030183 | 123-145 | in isoform 4 | |||
Sequence: AALIALWTLLWALIGQEVLPGGN → MSNKKCTWGENEKYKMQMIRLTV | ||||||
Alternative sequence | VSP_030184 | 146-565 | in isoform 4 | |||
Sequence: Missing | ||||||
Sequence conflict | 167 | in Ref. 2; BAB30495 and 3; AAH25002 | ||||
Sequence: K → R | ||||||
Sequence conflict | 263 | in Ref. 2; BAC25498 | ||||
Sequence: Q → G | ||||||
Alternative sequence | VSP_030185 | 270-565 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_030186 | 364-378 | in isoform 2 | |||
Sequence: ERLTQRRAFLVLSMC → AASTLAYMDLEDWSH | ||||||
Alternative sequence | VSP_030187 | 379-565 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EU846100 EMBL· GenBank· DDBJ | ACF60498.1 EMBL· GenBank· DDBJ | mRNA | ||
AK007064 EMBL· GenBank· DDBJ | BAB24849.1 EMBL· GenBank· DDBJ | mRNA | ||
AK015318 EMBL· GenBank· DDBJ | BAB29794.1 EMBL· GenBank· DDBJ | mRNA | ||
AK016883 EMBL· GenBank· DDBJ | BAC25498.1 EMBL· GenBank· DDBJ | mRNA | ||
AK016917 EMBL· GenBank· DDBJ | BAB30495.1 EMBL· GenBank· DDBJ | mRNA | ||
AK029525 EMBL· GenBank· DDBJ | BAC26494.1 EMBL· GenBank· DDBJ | mRNA | ||
BC025002 EMBL· GenBank· DDBJ | AAH25002.1 EMBL· GenBank· DDBJ | mRNA |