Q8C0V9 · FRMD6_MOUSE
- ProteinFERM domain-containing protein 6
- GeneFrmd6
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids622 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | apical junction complex | |
Cellular Component | cytoplasm | |
Cellular Component | cytoplasmic side of apical plasma membrane | |
Cellular Component | cytoskeleton | |
Cellular Component | plasma membrane | |
Biological Process | apical constriction | |
Biological Process | positive regulation of hippo signaling | |
Biological Process | protein localization | |
Biological Process | regulation of actin filament-based process |
Names & Taxonomy
Protein names
- Recommended nameFERM domain-containing protein 6
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineagecellular organisms > Eukaryota (eucaryotes) > Opisthokonta > Metazoa (metazoans) > Eumetazoa > Bilateria > Deuterostomia > Chordata (chordates) > Craniata > Vertebrata (vertebrates) > Gnathostomata (jawed vertebrates) > Teleostomi > Euteleostomi (bony vertebrates) > Sarcopterygii > Dipnotetrapodomorpha > Tetrapoda (tetrapods) > Amniota (amniotes) > Mammalia (mammals) > Theria > Eutheria (placentals) > Boreoeutheria > Euarchontoglires > Glires (Rodents and rabbits) > Rodentia (rodent) > Myomorpha (mice and others) > Muroidea > Muridae > Murinae > Mus (mice) > Mus
Accessions
- Primary accessionQ8C0V9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Note: Can colocalize with actin.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000219449 | 1-622 | FERM domain-containing protein 6 | |||
Sequence: MNKLTFHNNKAMQDRRRVCIFLPNDKSVSIIINVKILCHQLLVQVCDLLRLKDSHLFGLSVIQNNEHVYMELSQKLYKYCPKEWKKEASKVRQYEVTWGIDQFGPPMIIHFRVQYYVENGKLISDRIARYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRKLHHGDYFEPEAYFPAWVVSKRGKDYILKHIPNMHKDQFALTASEAYLKYIKEAVRLDDVAIHYYRLYKDKREAEGSLTLGLTMRGIQIFQNLEEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLVYYTGCPTRSRHLLQLLSNSHRLYMNLQPVLRHLRKQEENEEKKQYRESYISDNLDLDMDPLEKRSRASGSSAGSVKHKRLSRHSTASHSSSHTSGIEADTKPRDPGPEDSCSGSAMHRKLKTCSSMTSHGSSHTSGVESGGKDRLEEDSQDEEIEMLVDDPRDLEPMPEESLEVSPEMCIYITEDMLLSRKLNGHSGLIVKEIGSSTSSSSETVVRLRGQSTDSLPQTICRKPKTSTDRHSLSLDDIRLYQKDFLRIAGLCQDTAQSYTFGCGHELDESGLYCNSCLAQQCVNIQDAFPVKRASKYFSLDLTHDEVPEFVV | ||||||
Modified residue | 522 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 523 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 525 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 542 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 544 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 16-328 | FERM | ||||
Sequence: RRVCIFLPNDKSVSIIINVKILCHQLLVQVCDLLRLKDSHLFGLSVIQNNEHVYMELSQKLYKYCPKEWKKEASKVRQYEVTWGIDQFGPPMIIHFRVQYYVENGKLISDRIARYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRKLHHGDYFEPEAYFPAWVVSKRGKDYILKHIPNMHKDQFALTASEAYLKYIKEAVRLDDVAIHYYRLYKDKREAEGSLTLGLTMRGIQIFQNLEEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLVYYTGCPTRSRHLLQLLSNSHRLYMNLQ | ||||||
Region | 357-452 | Disordered | ||||
Sequence: LDMDPLEKRSRASGSSAGSVKHKRLSRHSTASHSSSHTSGIEADTKPRDPGPEDSCSGSAMHRKLKTCSSMTSHGSSHTSGVESGGKDRLEEDSQD | ||||||
Compositional bias | 418-439 | Polar residues | ||||
Sequence: HRKLKTCSSMTSHGSSHTSGVE |
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q8C0V9-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length622
- Mass (Da)71,652
- Last updated2003-08-15 v2
- ChecksumEDDC8490CD84305C
Q8C0V9-2
- Name2
Q8C0V9-3
- Name3
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_008024 | 1-22 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_008025 | 23-33 | in isoform 2 | |||
Sequence: PNDKSVSIIIN → MCRIPRHCCLR | ||||||
Alternative sequence | VSP_008026 | 91-98 | in isoform 2 and isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 321 | in Ref. 1; BAC26574 | ||||
Sequence: H → Q | ||||||
Compositional bias | 418-439 | Polar residues | ||||
Sequence: HRKLKTCSSMTSHGSSHTSGVE | ||||||
Sequence conflict | 431 | in Ref. 1; BAC35785 | ||||
Sequence: G → S | ||||||
Alternative sequence | VSP_008027 | 499-571 | in isoform 3 | |||
Sequence: LIVKEIGSSTSSSSETVVRLRGQSTDSLPQTICRKPKTSTDRHSLSLDDIRLYQKDFLRIAGLCQDTAQSYTF → ELLGQAVACRSPQAGTSKNRTVVGTLNPPGRRATAGGLIPGQVPSVEEMGEGTRVVSMFCSARFSEASSVGLI | ||||||
Alternative sequence | VSP_008028 | 572-622 | in isoform 3 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK029709 EMBL· GenBank· DDBJ | BAC26574.1 EMBL· GenBank· DDBJ | mRNA | ||
AK054457 EMBL· GenBank· DDBJ | BAC35785.1 EMBL· GenBank· DDBJ | mRNA | ||
BC053929 EMBL· GenBank· DDBJ | AAH53929.1 EMBL· GenBank· DDBJ | mRNA |