Q8C0I0 · Q8C0I0_MOUSE

  • Protein
    PR domain zinc finger protein 1
  • Gene
    Zfp709
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

May be involved in transcriptional regulation.
Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular FunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding
Biological Processcell fate commitment
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    PR domain zinc finger protein 1
  • EC number

Gene names

    • Name
      Zfp709
    • Synonyms
      BC021921

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8C0I0

Organism-specific databases

Subcellular Location

Interaction

Subunit

Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-80KRAB
Domain225-252C2H2-type
Domain253-280C2H2-type
Domain281-308C2H2-type
Domain309-336C2H2-type
Domain337-364C2H2-type
Domain365-392C2H2-type
Domain393-420C2H2-type
Domain421-448C2H2-type
Domain449-476C2H2-type
Domain477-504C2H2-type
Domain505-532C2H2-type
Domain533-560C2H2-type
Domain561-588C2H2-type
Domain589-616C2H2-type
Domain617-644C2H2-type
Domain645-672C2H2-type
Domain673-700C2H2-type
Domain701-727C2H2-type

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    727
  • Mass (Da)
    84,205
  • Last updated
    2003-03-01 v1
  • Checksum
    69939EB83054B9DC
MGSVSFQDVAVTFTVEEWALLDPSQKKLHKDVMEETFRNLAAIGKTQEGQNIDEDHRYSRRNQRNEVVERLLEHSKGTESKEIFRQIPNTIVNRKSSHRTMLSENHVYKDNVLISQSSLTVSVPLQTPHKPHEYELHGENLYKFGECEKAFIYPECFLKHKDSGTRQRSYELNQCEEIFKSNDYIQIRVNDETREEICIDKQHYAFNYPDFLQYVEKVHTGKKPYACKQCGKTFSFLSNIKRHERIHSGEKPYRCNICDKAFTCSTNFQEHERTHTGEKPYLCTQCGKSFSFLSNIRRHERTHTGEKPYRCNACGKAFSYLTNFQDHERTHTGEKPYVCTQCGKAFTYYYSFQTHKRCHTGEKPYVCKQCGKAFSYYNSIQTHKRCHTGEKPYVCKLCAKAFTTLSSLRYHERIHSGEKPHVCLQCGKGFNSSSTLRIHERTHTGEKPYKCKKCGKVFSVDSSLRCHERIHSGEKPYVCKQCGKAFTRHTSLRCHERIHCGEKPYICKQCGKGFISSSNFRKHEWTHSGEKLCVCKLCGKAFTGHSSLQRHERIHSGEKPYVCKHCGKDFSSLSGCQRHEQIHTGEKPYVCKNCGKAFTNPSALRNHERIHSGEKPYVCGQCGKGFISFSKFRIHERIHTGEKPYKCKQCGKAFTGHSSLRRHERIHSGEKPFVCKHCGKSFYTLSDCQRHEQIHTGEKPSICKQCGKAFTRSSSLKIHDKTHSRSP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK031294
EMBL· GenBank· DDBJ
BAC27336.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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