Q8C0I0 · Q8C0I0_MOUSE
- ProteinPR domain zinc finger protein 1
- GeneZfp709
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids727 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
May be involved in transcriptional regulation.
Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | DNA-binding transcription repressor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | RNA polymerase II transcription regulatory region sequence-specific DNA binding | |
Biological Process | cell fate commitment | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePR domain zinc finger protein 1
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8C0I0
Organism-specific databases
Interaction
Subunit
Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-80 | KRAB | ||||
Sequence: VSFQDVAVTFTVEEWALLDPSQKKLHKDVMEETFRNLAAIGKTQEGQNIDEDHRYSRRNQRNEVVERLLEHSKGTES | ||||||
Domain | 225-252 | C2H2-type | ||||
Sequence: YACKQCGKTFSFLSNIKRHERIHSGEKP | ||||||
Domain | 253-280 | C2H2-type | ||||
Sequence: YRCNICDKAFTCSTNFQEHERTHTGEKP | ||||||
Domain | 281-308 | C2H2-type | ||||
Sequence: YLCTQCGKSFSFLSNIRRHERTHTGEKP | ||||||
Domain | 309-336 | C2H2-type | ||||
Sequence: YRCNACGKAFSYLTNFQDHERTHTGEKP | ||||||
Domain | 337-364 | C2H2-type | ||||
Sequence: YVCTQCGKAFTYYYSFQTHKRCHTGEKP | ||||||
Domain | 365-392 | C2H2-type | ||||
Sequence: YVCKQCGKAFSYYNSIQTHKRCHTGEKP | ||||||
Domain | 393-420 | C2H2-type | ||||
Sequence: YVCKLCAKAFTTLSSLRYHERIHSGEKP | ||||||
Domain | 421-448 | C2H2-type | ||||
Sequence: HVCLQCGKGFNSSSTLRIHERTHTGEKP | ||||||
Domain | 449-476 | C2H2-type | ||||
Sequence: YKCKKCGKVFSVDSSLRCHERIHSGEKP | ||||||
Domain | 477-504 | C2H2-type | ||||
Sequence: YVCKQCGKAFTRHTSLRCHERIHCGEKP | ||||||
Domain | 505-532 | C2H2-type | ||||
Sequence: YICKQCGKGFISSSNFRKHEWTHSGEKL | ||||||
Domain | 533-560 | C2H2-type | ||||
Sequence: CVCKLCGKAFTGHSSLQRHERIHSGEKP | ||||||
Domain | 561-588 | C2H2-type | ||||
Sequence: YVCKHCGKDFSSLSGCQRHEQIHTGEKP | ||||||
Domain | 589-616 | C2H2-type | ||||
Sequence: YVCKNCGKAFTNPSALRNHERIHSGEKP | ||||||
Domain | 617-644 | C2H2-type | ||||
Sequence: YVCGQCGKGFISFSKFRIHERIHTGEKP | ||||||
Domain | 645-672 | C2H2-type | ||||
Sequence: YKCKQCGKAFTGHSSLRRHERIHSGEKP | ||||||
Domain | 673-700 | C2H2-type | ||||
Sequence: FVCKHCGKSFYTLSDCQRHEQIHTGEKP | ||||||
Domain | 701-727 | C2H2-type | ||||
Sequence: SICKQCGKAFTRSSSLKIHDKTHSRSP |
Sequence similarities
Belongs to the class V-like SAM-binding methyltransferase superfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length727
- Mass (Da)84,205
- Last updated2003-03-01 v1
- Checksum69939EB83054B9DC
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK031294 EMBL· GenBank· DDBJ | BAC27336.1 EMBL· GenBank· DDBJ | mRNA |