We identify de novo DNA sequence motifs associated with individual components that define temporally varying modes of gene expression control. Analysis of SDA components also led us to identify a rare population of macrophages within the seminiferous tubules of Mlh3(-/-) and Hormad1(-/-) mice an area typically associated with immune privilege
Double mutant mice homozygous for the Mlh3DN/DN and Mus81-/- mutations show losses in chiasmata close to those observed in Mlh3-/- males indicating that the MUS81-EME1-regulated crossover pathway can only partially account for the increased residual chiasmata in Mlh3DN/DN spermatocytes
these data identify Mlh1 and Mlh3 as novel critical genetic modifiers of HTT CAG instability point to Mlh1 genetic variation as the likely source of the instability difference in B6 and 129 strains
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