Q8BZB3 · TM266_MOUSE

  • Protein
    Transmembrane protein 266
  • Gene
    Tmem266
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum. Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear. Undergoes both rapid and slow structural rearrangements in response to changes in voltage. Contains a zinc-binding site that can regulate the slow conformational transition.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentdendrite
Cellular Componentperikaryon
Cellular Componentplasma membrane
Molecular Functionprotein homodimerization activity
Biological Processmonoatomic ion transport
Biological Processtransmembrane transport

Names & Taxonomy

Protein names

  • Recommended name
    Transmembrane protein 266

Gene names

    • Name
      Tmem266

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8BZB3
  • Secondary accessions
    • B1B1B3
    • Q6NVG3

Proteomes

Organism-specific databases

Subcellular Location

Perikaryon
Note: Present in the dendrites and soma of cerebellar granule neurons, but not in their axon.

Isoform 1

Cell membrane
; Multi-pass membrane protein

Isoform 2

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-102Cytoplasmic
Transmembrane103-123Helical; Name=Segment S1
Topological domain124-130Extracellular
Transmembrane131-151Helical; Name=Segment S2
Topological domain152-169Cytoplasmic
Transmembrane170-190Helical; Name=Segment S3
Topological domain191-199Extracellular
Transmembrane200-220Helical; Name=Segment S4
Topological domain221-538Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

TMEM266-deficient mice show no significant difference in rota-rod test and gait analysis but show a significant reduction in stereotypic behaviors.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis252Loss of homodimerization.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 26 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002440961-538Transmembrane protein 266

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

In brain, present in the granule layer of the cerebellar cortex (PubMed:25165868).
Localizes on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum (at protein level) (PubMed:25165868).

Isoform 1

Predominantly expressed in granule cells in cerebellum (at protein level) (PubMed:35574701).

Isoform 2

Predominantly expressed in granule cells in cerebellum (at protein level) (PubMed:35574701).

Gene expression databases

Interaction

Subunit

Isoform 1

Homodimer; disulfide-linked.

Isoform 2

Homodimer; disulfide-linked.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for coiled coil, compositional bias, region.

TypeIDPosition(s)Description
Coiled coil232-278
Compositional bias380-420Polar residues
Region380-435Disordered
Region453-483Disordered

Domain

The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Transplantation of the transmembrane segment S4 into HVCN1, generates a functional voltage-activated proton channel.
The coiled coil mediates homodimerization.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q8BZB3-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    538
  • Mass (Da)
    58,897
  • Last updated
    2007-01-09 v3
  • Checksum
    D3F14858BD140C65
MALVTSFNMANPQPAIEGGISEVEIISQQVDEETKSIAPVQLVNFAYRDLPLAAVDLSTGGSQLLSNLDEEYQREGSDWLKPCCGKRAAVWQVFLLSASLNSFLVACVILVVILLTLELLIDTKLLQFSNAFQFAGVIHWISLVILSVFFSETVLRIVVLGIWDYIENKIEVFDGAVIILSLAPMVASTVANGPRSPWDAISLIIMFRIWRVKRVIDAYVLPVKLEMEMVTQQYEKAKAIQDEQLERLTQICQEQGFEIRQLRAHLAQQDLDLAAEREAALQAPHVLSQPRSRYKVVEAGTWAEETAAESIVEELRPSQEATVKDDMNSYISQYYNGPSSDSGAPEPAVCVVTTAAIDIHQPNVPSDLFSVDLPLKLSGNSTCASATSETTSHSTCGSVTRAQSASSQTLGSSTDCSTPREELLPSKPRSSPLPLLLPPQQLVAEATVQDLMSSLSKDPCPSHKALDPAPLAQPTPLGSVQTSPELEHRVSLFNQKNQEALPVLQINPVIHLQPTAGLEEKFRSLESKEPKLHTVPEA

Q8BZB3-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-65: Missing
    • 66-76: SNLDEEYQREG → MMLFQPHRAFR
    • 341-363: DSGAPEPAVCVVTTAAIDIHQPN → GKSGLGLFACTMQPQDTCDPSKP
    • 364-538: Missing

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0221091-65in isoform 2
Alternative sequenceVSP_02211066-76in isoform 2
Alternative sequenceVSP_019514341-363in isoform 2
Alternative sequenceVSP_019515364-538in isoform 2
Compositional bias380-420Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK036040
EMBL· GenBank· DDBJ
BAC29283.1
EMBL· GenBank· DDBJ
mRNA
CT025532
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC068128
EMBL· GenBank· DDBJ
AAH68128.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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