Q8BZB3 · TM266_MOUSE
- ProteinTransmembrane protein 266
- GeneTmem266
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids538 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum. Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear. Undergoes both rapid and slow structural rearrangements in response to changes in voltage. Contains a zinc-binding site that can regulate the slow conformational transition.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | dendrite | |
Cellular Component | perikaryon | |
Cellular Component | plasma membrane | |
Molecular Function | protein homodimerization activity | |
Biological Process | monoatomic ion transport | |
Biological Process | transmembrane transport |
Names & Taxonomy
Protein names
- Recommended nameTransmembrane protein 266
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8BZB3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Present in the dendrites and soma of cerebellar granule neurons, but not in their axon.
Isoform 1
Cell membrane ; Multi-pass membrane protein
Isoform 2
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-102 | Cytoplasmic | ||||
Sequence: MALVTSFNMANPQPAIEGGISEVEIISQQVDEETKSIAPVQLVNFAYRDLPLAAVDLSTGGSQLLSNLDEEYQREGSDWLKPCCGKRAAVWQVFLLSASLNS | ||||||
Transmembrane | 103-123 | Helical; Name=Segment S1 | ||||
Sequence: FLVACVILVVILLTLELLIDT | ||||||
Topological domain | 124-130 | Extracellular | ||||
Sequence: KLLQFSN | ||||||
Transmembrane | 131-151 | Helical; Name=Segment S2 | ||||
Sequence: AFQFAGVIHWISLVILSVFFS | ||||||
Topological domain | 152-169 | Cytoplasmic | ||||
Sequence: ETVLRIVVLGIWDYIENK | ||||||
Transmembrane | 170-190 | Helical; Name=Segment S3 | ||||
Sequence: IEVFDGAVIILSLAPMVASTV | ||||||
Topological domain | 191-199 | Extracellular | ||||
Sequence: ANGPRSPWD | ||||||
Transmembrane | 200-220 | Helical; Name=Segment S4 | ||||
Sequence: AISLIIMFRIWRVKRVIDAYV | ||||||
Topological domain | 221-538 | Cytoplasmic | ||||
Sequence: LPVKLEMEMVTQQYEKAKAIQDEQLERLTQICQEQGFEIRQLRAHLAQQDLDLAAEREAALQAPHVLSQPRSRYKVVEAGTWAEETAAESIVEELRPSQEATVKDDMNSYISQYYNGPSSDSGAPEPAVCVVTTAAIDIHQPNVPSDLFSVDLPLKLSGNSTCASATSETTSHSTCGSVTRAQSASSQTLGSSTDCSTPREELLPSKPRSSPLPLLLPPQQLVAEATVQDLMSSLSKDPCPSHKALDPAPLAQPTPLGSVQTSPELEHRVSLFNQKNQEALPVLQINPVIHLQPTAGLEEKFRSLESKEPKLHTVPEA |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
TMEM266-deficient mice show no significant difference in rota-rod test and gait analysis but show a significant reduction in stereotypic behaviors.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 252 | Loss of homodimerization. | ||||
Sequence: C → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 26 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000244096 | 1-538 | Transmembrane protein 266 | |||
Sequence: MALVTSFNMANPQPAIEGGISEVEIISQQVDEETKSIAPVQLVNFAYRDLPLAAVDLSTGGSQLLSNLDEEYQREGSDWLKPCCGKRAAVWQVFLLSASLNSFLVACVILVVILLTLELLIDTKLLQFSNAFQFAGVIHWISLVILSVFFSETVLRIVVLGIWDYIENKIEVFDGAVIILSLAPMVASTVANGPRSPWDAISLIIMFRIWRVKRVIDAYVLPVKLEMEMVTQQYEKAKAIQDEQLERLTQICQEQGFEIRQLRAHLAQQDLDLAAEREAALQAPHVLSQPRSRYKVVEAGTWAEETAAESIVEELRPSQEATVKDDMNSYISQYYNGPSSDSGAPEPAVCVVTTAAIDIHQPNVPSDLFSVDLPLKLSGNSTCASATSETTSHSTCGSVTRAQSASSQTLGSSTDCSTPREELLPSKPRSSPLPLLLPPQQLVAEATVQDLMSSLSKDPCPSHKALDPAPLAQPTPLGSVQTSPELEHRVSLFNQKNQEALPVLQINPVIHLQPTAGLEEKFRSLESKEPKLHTVPEA |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
In brain, present in the granule layer of the cerebellar cortex (PubMed:25165868).
Localizes on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum (at protein level) (PubMed:25165868).
Localizes on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum (at protein level) (PubMed:25165868).
Isoform 1
Predominantly expressed in granule cells in cerebellum (at protein level) (PubMed:35574701).
Isoform 2
Predominantly expressed in granule cells in cerebellum (at protein level) (PubMed:35574701).
Gene expression databases
Structure
Family & Domains
Features
Showing features for coiled coil, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 232-278 | |||||
Sequence: QQYEKAKAIQDEQLERLTQICQEQGFEIRQLRAHLAQQDLDLAAERE | ||||||
Compositional bias | 380-420 | Polar residues | ||||
Sequence: NSTCASATSETTSHSTCGSVTRAQSASSQTLGSSTDCSTPR | ||||||
Region | 380-435 | Disordered | ||||
Sequence: NSTCASATSETTSHSTCGSVTRAQSASSQTLGSSTDCSTPREELLPSKPRSSPLPL | ||||||
Region | 453-483 | Disordered | ||||
Sequence: SSLSKDPCPSHKALDPAPLAQPTPLGSVQTS |
Domain
The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Transplantation of the transmembrane segment S4 into HVCN1, generates a functional voltage-activated proton channel.
The coiled coil mediates homodimerization.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q8BZB3-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length538
- Mass (Da)58,897
- Last updated2007-01-09 v3
- ChecksumD3F14858BD140C65
Q8BZB3-2
- Name2
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_022109 | 1-65 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_022110 | 66-76 | in isoform 2 | |||
Sequence: SNLDEEYQREG → MMLFQPHRAFR | ||||||
Alternative sequence | VSP_019514 | 341-363 | in isoform 2 | |||
Sequence: DSGAPEPAVCVVTTAAIDIHQPN → GKSGLGLFACTMQPQDTCDPSKP | ||||||
Alternative sequence | VSP_019515 | 364-538 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 380-420 | Polar residues | ||||
Sequence: NSTCASATSETTSHSTCGSVTRAQSASSQTLGSSTDCSTPR |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK036040 EMBL· GenBank· DDBJ | BAC29283.1 EMBL· GenBank· DDBJ | mRNA | ||
CT025532 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC068128 EMBL· GenBank· DDBJ | AAH68128.1 EMBL· GenBank· DDBJ | mRNA |