PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197; SER-200; SER-206; SER-211; SER-212; SER-214 AND SER-711, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
Quercetin ameliorated insulin resistance via regulating METTL3-mediated N6-methyladenosine modification of PRKD2 mRNA in skeletal muscle and C2C12 myocyte cell line.
The results indicate that down-regulation of PRKD2 is involved in the pathogenesis of hyperinsulinemia which in turn results in insulin resistance and metabolic disorders.
Our studies demonstrate that PKD1/2 is a key regulator of MVB maturation and exosome secretion and constitutes a mediator of the DGK alpha effect on MVB secretory traffic.
Results reveal that whereas protein kinase D1 and protein kinase D2 are essential for neuronal polarity there exists a functional redundancy between the two proteins.
PKD2 acted as an amplification checkpoint for antigen-stimulated digital cytokine responses and translated the differential strength of TCR signaling to determine the number of naive CD8(+) T cells that became effector cells.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.