Q8BYR8 · S41A2_MOUSE
- ProteinSolute carrier family 41 member 2
- GeneSlc41a2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids573 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Acts as a plasma-membrane magnesium transporter (PubMed:15809054).
Can also mediate the transport of other divalent metal cations in an order of Ba2+ > Ni2+ > Co2+ > Fe2+ > Mn2+ (PubMed:15809054).
Can also mediate the transport of other divalent metal cations in an order of Ba2+ > Ni2+ > Co2+ > Fe2+ > Mn2+ (PubMed:15809054).
Catalytic activity
- Mg2+(in) = Mg2+(out)
- Mn2+(in) = Mn2+(out)
- Co2+(in) = Co2+(out)
- Ni2+(in) = Ni2+(out)
- Fe2+(in) = Fe2+(out)
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
0.34 mM | Mg2+ |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | inorganic cation transmembrane transporter activity | |
Molecular Function | monoatomic cation transmembrane transporter activity | |
Biological Process | cobalt ion transport | |
Biological Process | iron ion transport | |
Biological Process | magnesium ion transport | |
Biological Process | manganese ion transport | |
Biological Process | metal ion transport | |
Biological Process | nickel cation transport |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSolute carrier family 41 member 2
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8BYR8
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-162 | Extracellular | |||
Transmembrane | 163-183 | Helical | |||
Topological domain | 184-195 | Cytoplasmic | |||
Transmembrane | 196-216 | Helical | |||
Topological domain | 217-245 | Extracellular | |||
Transmembrane | 246-266 | Helical | |||
Topological domain | 267-282 | Cytoplasmic | |||
Transmembrane | 283-303 | Helical | |||
Topological domain | 304-313 | Extracellular | |||
Transmembrane | 314-334 | Helical | |||
Topological domain | 335-347 | Cytoplasmic | |||
Transmembrane | 348-368 | Helical | |||
Topological domain | 369-376 | Extracellular | |||
Transmembrane | 377-397 | Helical | |||
Topological domain | 398-406 | Cytoplasmic | |||
Transmembrane | 407-427 | Helical | |||
Topological domain | 428-469 | Extracellular | |||
Transmembrane | 470-490 | Helical | |||
Topological domain | 491-498 | Cytoplasmic | |||
Transmembrane | 499-519 | Helical | |||
Topological domain | 520-543 | Extracellular | |||
Transmembrane | 544-564 | Helical | |||
Topological domain | 565-573 | Cytoplasmic | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Chain | PRO_0000295042 | 1-573 | UniProt | Solute carrier family 41 member 2 | ||
Modified residue (large scale data) | 113 | PTMeXchange | Phosphotyrosine | |||
Modified residue (large scale data) | 116 | PTMeXchange | Phosphotyrosine | |||
Modified residue (large scale data) | 118 | PTMeXchange | Phosphotyrosine | |||
Modified residue | 137 | UniProt | Phosphoserine | |||
Modified residue (large scale data) | 137 | PTMeXchange | Phosphoserine | |||
Modified residue | 138 | UniProt | Phosphoserine | |||
Modified residue (large scale data) | 138 | PTMeXchange | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length573
- Mass (Da)62,305
- Last updated2003-03-01 v1
- MD5 Checksum54CD74794F96BC59EF1517DDCD5C3E89
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK038549 EMBL· GenBank· DDBJ | BAC30038.1 EMBL· GenBank· DDBJ | mRNA |