Q8BWQ5 · DCLK3_MOUSE
- ProteinSerine/threonine-protein kinase DCLK3
- GeneDclk3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids790 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site, active site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | protein kinase activity | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | intracellular signal transduction | |
Biological Process | negative regulation of protein localization to nucleus | |
Biological Process | protein localization to nucleus |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase DCLK3
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8BWQ5
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000252255 | 1-790 | Serine/threonine-protein kinase DCLK3 | |||
Sequence: MPAAPVLRPPPPPATPAPPAPSRPAPPIPGHRGPCDHSLKCLSSKISERKLPGPWLPAGRGPLEKPVLGPRGAVMPLFSPQSSLHSVRAEHSPLKPRVVTVVKLGGQPLRKATLLLNRRSVQTFEQLLSDISEALGFPRWKNDRVRKLFTLKGREVKSVSDFFREGDAFIAMGKEPLTLKSIQLAMEELYPKNRALALAPHSRVPSPRLRSRLPSKLLKGSHRCGEAGSYSAEMESKAVSRHQGKTSTVLAPEDKARAQKWVRGKQESEPGGPPSPGAATQEETHASGEKHLGVEIEKTSGEIVRCEKCKRERELQLGLQREPCPLGTSELDLGRAQKRDSEKLVRTKSCRRPSEAKSTDGEEGWKGDSHRGSPRDPPQELRRPNSNSDKKEIRGSESQDSHPQGAPKAQKDLVEGPPAVEEGPIDMRREDRHTCRSKHAAWLRREQQAEPPQLPRTRGEEKQAEHEKKPGGLGERRAPEKESKRKLEEKRPERPSGRKPRPKGIISADVEKHYDIGGVIGDGNFATVKECRHRETKQAYAMKMIDKSQLKGKEDIVDSEILIIQSLSHPNIVKLHEVYETEAEIYLIMEYVQGGDLFDAIVENVKFPEPEAAVMITDLCKALVHMHDKNIVHRDVKPENLLVQRNEDKSITLKLADFGLAKYVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQVGQFEFLSPYWDNISDAAKDLVRNLLEVDPKKRYTAEQVLQHPWIEMVGHTNTGNSQKEESPNS |
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in brain and to a lower extent in liver and kidney.
Gene expression databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
XENO | Q8BWQ5 | TADA3 O75528 | 2 | EBI-16518538, EBI-473249 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-31 | Pro residues | ||||
Sequence: MPAAPVLRPPPPPATPAPPAPSRPAPPIPGH | ||||||
Region | 1-37 | Disordered | ||||
Sequence: MPAAPVLRPPPPPATPAPPAPSRPAPPIPGHRGPCDH | ||||||
Domain | 97-183 | Doublecortin | ||||
Sequence: RVVTVVKLGGQPLRKATLLLNRRSVQTFEQLLSDISEALGFPRWKNDRVRKLFTLKGREVKSVSDFFREGDAFIAMGKEPLTLKSIQ | ||||||
Region | 201-290 | Disordered | ||||
Sequence: HSRVPSPRLRSRLPSKLLKGSHRCGEAGSYSAEMESKAVSRHQGKTSTVLAPEDKARAQKWVRGKQESEPGGPPSPGAATQEETHASGEK | ||||||
Region | 315-506 | Disordered | ||||
Sequence: LQLGLQREPCPLGTSELDLGRAQKRDSEKLVRTKSCRRPSEAKSTDGEEGWKGDSHRGSPRDPPQELRRPNSNSDKKEIRGSESQDSHPQGAPKAQKDLVEGPPAVEEGPIDMRREDRHTCRSKHAAWLRREQQAEPPQLPRTRGEEKQAEHEKKPGGLGERRAPEKESKRKLEEKRPERPSGRKPRPKGII | ||||||
Compositional bias | 333-398 | Basic and acidic residues | ||||
Sequence: LGRAQKRDSEKLVRTKSCRRPSEAKSTDGEEGWKGDSHRGSPRDPPQELRRPNSNSDKKEIRGSES | ||||||
Compositional bias | 422-445 | Basic and acidic residues | ||||
Sequence: EGPIDMRREDRHTCRSKHAAWLRR | ||||||
Compositional bias | 455-506 | Basic and acidic residues | ||||
Sequence: PRTRGEEKQAEHEKKPGGLGERRAPEKESKRKLEEKRPERPSGRKPRPKGII | ||||||
Domain | 514-771 | Protein kinase | ||||
Sequence: YDIGGVIGDGNFATVKECRHRETKQAYAMKMIDKSQLKGKEDIVDSEILIIQSLSHPNIVKLHEVYETEAEIYLIMEYVQGGDLFDAIVENVKFPEPEAAVMITDLCKALVHMHDKNIVHRDVKPENLLVQRNEDKSITLKLADFGLAKYVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQVGQFEFLSPYWDNISDAAKDLVRNLLEVDPKKRYTAEQVLQHPWI |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length790
- Mass (Da)88,228
- Last updated2011-05-31 v2
- Checksum23A56EBD3453BBAD
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-31 | Pro residues | ||||
Sequence: MPAAPVLRPPPPPATPAPPAPSRPAPPIPGH | ||||||
Compositional bias | 333-398 | Basic and acidic residues | ||||
Sequence: LGRAQKRDSEKLVRTKSCRRPSEAKSTDGEEGWKGDSHRGSPRDPPQELRRPNSNSDKKEIRGSES | ||||||
Compositional bias | 422-445 | Basic and acidic residues | ||||
Sequence: EGPIDMRREDRHTCRSKHAAWLRR | ||||||
Compositional bias | 455-506 | Basic and acidic residues | ||||
Sequence: PRTRGEEKQAEHEKKPGGLGERRAPEKESKRKLEEKRPERPSGRKPRPKGII |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ286388 EMBL· GenBank· DDBJ | ABB89470.1 EMBL· GenBank· DDBJ | mRNA | ||
AK050312 EMBL· GenBank· DDBJ | BAC34182.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
BC056929 EMBL· GenBank· DDBJ | AAH56929.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |