the activation of PKA and cAMP/Epac1/Rap1 pathways could be required for basal mBAFF expression as well as being up-regulated in the TLR4-induced mBAFF expression
an important relationship between BAFF and c-MYC in CLL which may affect disease development and progression and suggests that inhibitors of the canonical NF-kappaB pathway may be effective in treatment of patients with this disease.
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