Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L.[...], Ponting C.P.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]StrainC57BL/6JCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCPLoS Biol. 7:E1000112-E1000112 (2009)Cited in99+99+
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]TissueBrainCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
The transcriptional landscape of the mammalian genome.Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B.[...], Hayashizaki Y.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-552StrainC57BL/6JTissueBrain cortex, Medulla oblongataCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 309:1559-1563 (2005)Cited in99+16Mapped to99+
Induced adiposity and adipocyte hypertrophy in mice lacking the AMP- activated protein kinase-alpha2 subunit.Villena J.A., Viollet B., Andreelli F., Kahn A., Vaulont S., Sul H.S.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCDiabetes 53:2242-2249 (2004)Cited in1Mapped to1
The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading.Jorgensen S.B., Nielsen J.N., Birk J.B., Olsen G.S., Viollet B., Andreelli F., Schjerling P., Vaulont S., Hardie D.G.[...], Wojtaszewski J.F.View abstractCited forFUNCTION IN PHOSPHORYLATION OF GYS1CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCDiabetes 53:3074-3081 (2004)Cited in2
The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases.Hurley R.L., Anderson K.A., Franzone J.M., Kemp B.E., Means A.R., Witters L.A.View abstractCited forPHOSPHORYLATION AT THR-172, ACTIVITY REGULATIONCategoriesPTM / Processing, FunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 280:29060-29066 (2005)Cited in4
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism.Koo S.-H., Flechner L., Qi L., Zhang X., Screaton R.A., Jeffries S., Hedrick S., Xu W., Boussouar F.[...], Montminy M.View abstractCited forFUNCTION IN PHOSPHORYLATION OF CRTC2CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 437:1109-1111 (2005)Cited in4Mapped to23
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.Shaw R.J., Lamia K.A., Vasquez D., Koo S.-H., Bardeesy N., Depinho R.A., Montminy M., Cantley L.C.View abstractCited forFUNCTION IN PHOSPHORYLATION OF CRTC2, PHOSPHORYLATION AT THR-172CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 310:1642-1646 (2005)Cited in4Mapped to18
AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits.Treebak J.T., Glund S., Deshmukh A., Klein D.K., Long Y.C., Jensen T.E., Jorgensen S.B., Viollet B., Andersson L.[...], Wojtaszewski J.F.View abstractCited forFUNCTION IN PHOSPHORYLATION OF TBC1D4CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCDiabetes 55:2051-2058 (2006)Cited in3Mapped to10
Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle.Kramer H.F., Witczak C.A., Fujii N., Jessen N., Taylor E.B., Arnolds D.E., Sakamoto K., Hirshman M.F., Goodyear L.J.View abstractCited forFUNCTION IN PHOSPHORYLATION OF TBC1D4CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCDiabetes 55:2067-2076 (2006)Cited in3Mapped to16
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.Jager S., Handschin C., St-Pierre J., Spiegelman B.M.View abstractCited forFUNCTION IN PHOSPHORYLATION OF PPARGC1ACategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 104:12017-12022 (2007)Cited in2Mapped to14
Large-scale phosphorylation analysis of mouse liver.Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.View abstractCited forPHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-377, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]TissueLiverCategoriesPTM / Processing, SequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 104:1488-1493 (2007)Cited in99+99+Mapped to1
Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)- linked polyubiquitin chains.Al-Hakim A.K., Zagorska A., Chapman L., Deak M., Peggie M., Alessi D.R.View abstractCited forUBIQUITINATIONCategoriesPTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochem. J. 411:249-260 (2008)Cited in5Mapped to6
AMPK phosphorylation of raptor mediates a metabolic checkpoint.Gwinn D.M., Shackelford D.B., Egan D.F., Mihaylova M.M., Mery A., Vasquez D.S., Turk B.E., Shaw R.J.View abstractCited forFUNCTION IN PHOSPHORYLATION OF RPTORCategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell 30:214-226 (2008)Cited in5Mapped to43
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation.Lamia K.A., Sachdeva U.M., DiTacchio L., Williams E.C., Alvarez J.G., Egan D.F., Vasquez D.S., Juguilon H., Panda S.[...], Evans R.M.View abstractCited forFUNCTION IN PHOSPHORYLATION OF CRY1CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 326:437-440 (2009)Cited in3Mapped to12
AMP-activated protein kinase (AMPK) cross-talks with canonical Wnt signaling via phosphorylation of beta-catenin at Ser 552.Zhao J., Yue W., Zhu M.J., Sreejayan N., Du M.View abstractCited forFUNCTION IN PHOSPHORYLATION OF CTNNB1CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochem. Biophys. Res. Commun. 395:146-151 (2010)Cited in3Mapped to12
A tissue-specific atlas of mouse protein phosphorylation and expression.Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.View abstractCited forPHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-377, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]TissueBrain, Brown adipose tissue, Heart, Kidney, Liver, PancreasCategoriesPTM / Processing, SequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 143:1174-1189 (2010)Cited in99+99+Mapped to6
Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation.Bungard D., Fuerth B.J., Zeng P.Y., Faubert B., Maas N.L., Viollet B., Carling D., Thompson C.B., Jones R.G., Berger S.L.View abstractCited forFUNCTION IN PHOSPHORYLATION OF H2B, MUTAGENESIS OF ASP-157CategoriesFunction, PTM / Processing, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 329:1201-1205 (2010)Cited in13Mapped to26
AMP-activated protein kinase regulates beta-catenin transcription via histone deacetylase 5.Zhao J.X., Yue W.F., Zhu M.J., Du M.View abstractCited forFUNCTION IN PHOSPHORYLATION OF HDAC5, MUTAGENESIS OF LYS-45CategoriesFunction, PTM / Processing, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 286:16426-16434 (2011)Cited in2Mapped to10
Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.Loffler A.S., Alers S., Dieterle A.M., Keppeler H., Franz-Wachtel M., Kundu M., Campbell D.G., Wesselborg S., Alessi D.R., Stork B.View abstractCited forPHOSPHORYLATION BY ULK1CategoriesPTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCAutophagy 7:696-706 (2011)Cited in23Mapped to12
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.Li Y., Xu S., Mihaylova M.M., Zheng B., Hou X., Jiang B., Park O., Luo Z., Lefai E.[...], Zang M.View abstractCited forFUNCTION IN PHOSPHORYLATION OF SREBF1 AND SREBF2, ACTIVITY REGULATIONCategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell Metab. 13:376-388 (2011)Cited in4Mapped to14
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.Kim J., Kundu M., Viollet B., Guan K.L.View abstractCited forFUNCTION IN PHOSPHORYLATION OF ULK1CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Cell Biol. 13:132-141 (2011)Cited in6Mapped to60
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.Egan D.F., Shackelford D.B., Mihaylova M.M., Gelino S., Kohnz R.A., Mair W., Vasquez D.S., Joshi A., Gwinn D.M.[...], Shaw R.J.View abstractCited forFUNCTION IN PHOSPHORYLATION OF ULK1CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 331:456-461 (2011)Cited in7Mapped to19
The ancient drug salicylate directly activates AMP-activated protein kinase.Hawley S.A., Fullerton M.D., Ross F.A., Schertzer J.D., Chevtzoff C., Walker K.J., Peggie M.W., Zibrova D., Green K.A.[...], Hardie D.G.View abstractCited forACTIVITY REGULATION BY SALICYLATECategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 336:918-922 (2012)Cited in2
Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy.Kim J., Kim Y.C., Fang C., Russell R.C., Kim J.H., Fan W., Liu R., Zhong Q., Guan K.L.View abstractCited forFUNCTION, PHOSPHORYLATION AT THR-172, ACTIVITY REGULATIONCategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 152:290-303 (2013)Cited in5Mapped to20