Q8BRB7 · KAT6B_MOUSE

  • Protein
    Histone acetyltransferase KAT6B
  • Gene
    Kat6b
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (By similarity).
Involved in cerebral cortex development

Catalytic activity

Features

Showing features for binding site, active site.

118722004006008001,0001,2001,4001,6001,800
TypeIDPosition(s)Description
Binding site674-678acetyl-CoA (UniProtKB | ChEBI)
Binding site683-689acetyl-CoA (UniProtKB | ChEBI)
Active site709Proton donor/acceptor
Binding site713acetyl-CoA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchromatin
Cellular ComponentMOZ/MORF histone acetyltransferase complex
Cellular Componentnucleosome
Cellular Componentnucleus
Molecular Functionchromatin binding
Molecular FunctionDNA binding
Molecular Functionhistone acetyltransferase activity
Molecular Functionhistone H3 acetyltransferase activity
Molecular Functionmetal ion binding
Molecular Functionpeptide-lysine-N-acetyltransferase activity
Molecular Functionprotein-containing complex binding
Molecular Functiontranscription coactivator activity
Molecular Functiontranscription coregulator activity
Biological Processcellular response to leukemia inhibitory factor
Biological Processnegative regulation of DNA-templated transcription
Biological Processnucleosome assembly
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of developmental process
Biological Processregulation of DNA-templated transcription
Biological Processregulation of hemopoiesis
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone acetyltransferase KAT6B
  • EC number
  • Alternative names
    • MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4 (MYST-4)
    • Protein querkopf

Gene names

    • Name
      Kat6b
    • Synonyms
      Myst4

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8BRB7
  • Secondary accessions
    • E9QK86
    • Q7TNW5
    • Q8BG35
    • Q8C441
    • Q9JKX5

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Mice have a low body weight, craniofacial abnormalities, and defects in cortex development. Mice carrying a gene trap insertion in the gene, produces approximately 5% of the normal amount of mRNA. The hypomorphic mutant displays a number of defects that mirror SBBYSS syndrome, although the phenotype is milder. Mice are of normal size at birth but fail to thrive and have brain developmental defects as well as craniofacial defects. Observed abnormalities include short and narrow palpebral fissures, low set ears, and malocclusion. Similar to individuals with SBBYSS, mice carrying the gene trap insertion have long, slender feet and disproportionally long first digits.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 142 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue, cross-link.

TypeIDPosition(s)Description
ChainPRO_00000515771-1872Histone acetyltransferase KAT6B
Modified residue356Phosphoserine
Cross-link491Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue633N6-acetyllysine; by autocatalysis
Modified residue856N6-acetyllysine
Modified residue860N6-acetyllysine
Modified residue862N6-acetyllysine
Modified residue866Phosphoserine

Post-translational modification

Autoacetylation at Lys-633 is required for proper function.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Ubiquitously expressed.

Developmental stage

Strongly expressed in the ventricular zone of the developing cerebral cortex.

Gene expression databases

Interaction

Subunit

Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with RUNX1 and RUNX2.
View interactors in UniProtKB
View CPX-803 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, zinc finger, compositional bias.

TypeIDPosition(s)Description
Domain1-77SAMD1-like winged helix (WH)
Region70-103Disordered
Domain104-177H15
Region168-207Disordered
Zinc finger214-273PHD-type 1
Zinc finger270-321PHD-type 2
Region361-417Disordered
Region362-535Negatively regulates HAT activity
Domain533-807MYST-type HAT
Region536-826Catalytic
Zinc finger566-591C2HC MYST-type
Region570-826Interaction with BRPF1
Compositional bias846-861Polar residues
Region846-1018Disordered
Compositional bias885-909Acidic residues
Compositional bias928-943Basic residues
Compositional bias947-961Polar residues
Compositional bias1001-1018Basic and acidic residues
Region1031-1252Disordered
Compositional bias1090-1109Basic and acidic residues
Compositional bias1151-1178Acidic residues
Compositional bias1179-1206Basic and acidic residues
Compositional bias1207-1233Acidic residues
Compositional bias1234-1252Basic and acidic residues
Region1283-1358Disordered
Compositional bias1306-1324Basic and acidic residues
Region1359-1872Interaction with RUNX1 and RUNX2
Region1388-1418Disordered

Domain

The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.

Sequence similarities

Belongs to the MYST (SAS/MOZ) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q8BRB7-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,872
  • Mass (Da)
    208,526
  • Last updated
    2011-07-27 v3
  • Checksum
    2807D9D473EE22C7
MVKLANPLYTEWILEAVQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGTFPKPTKGSKGPPCNDLRNVDWNKLLKRAIEGLEEPNGSSLKNIEKYLRSQSDLTGTTNHPAFQQRLRLGAKRAVNNGRLLKEGPQYRVNSGSSDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTANVKALRWQCIECKTCSACRVQGKNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVTSDEGSMSAFTGRGSPGRGQKTKVSTTPSSGHAASGKHSSSRLAVTDPTRPGATTKTTTSSTYISASTLKVNKKTKGLIDGLTKFFTPSPDGRRSRGEIIDFSKHYRPRKKVSQKQSCTSHVLATDTDIKISIKQESADVSLVGNKELVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYPQEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNMSKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQHQRQGFGRFLIDFSYLLSRREGQAGSPEKPLSDLGRLSYLAYWKSVILEYLYRHHERHISIKAISRATGMCPHDIATTLQHLHMIDRRDGRFVIIRREKLILGHMEKLKNCSRPNELDPESLRWTPMLISNAVVSEEEREAEKEAERLMEQASCWEKEEQEILSSRVSSRQSSAKVQSKNKYLHSPERRPVAGERGQLLELSKESSEEEEEEEEEDDEEEEEEEEEESIQTSPPRLTKPQSVSIKRKRPFVVKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMPQLEPTCEIPVEEGGRKPVLRKAFPHQPGKKRQTEEEEGEDNHFFKTAALCRKDVDDDAEHLKEGSKDNPEPLKCRQVWPKGAKRGLSKWKQSKERKTGFKLNLYTPPETPMEPEDQVTIEEQKELSEDKGSPVGMEREVTETVDALLPQEGSRREETGIPVSPHKSPGGKVDEEDLIRGEEEGEEEGEEEGEREEQEEEEEVTTEKDLDGAKSKENPEPEISMEKEDPVHLGDHEEDEDEEEEPSHNEDHDADDEDDGHMEAANMERGDLPRETFKDALEGQEAFLDLSIQPSHSNPEVLMNCGVDLTMSCNSEPKELAGDTGTAPESDAEPPEEQTQKQDQKNSDGVDAELEEGGPAAVEIDSETAQAVQSLTQENREHDDTFPDCAETQEACRSLQNYTHTDQSPQIATTLDECQQSDHSSPVSSVHSHPGQSVRSVNSPSVPALENSYAQISPDQTAITVPPLQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNGSSQNSCSYSSLTSSNLTQNSCAVTQQMSNISGSCSMLQQTSISSPPTCSVKSPQGCVVERPPSSSQQLAQCSMAANFTPPMQLADIPETSNANIGLYERMGQSDFGAGHYPQPSATFSLAKLQQLTNTLIDHSLPYSHSAAVTSYANSASLSTPLSNTGLVQLSQSPHSVPGGPQAQATMTPPPNLTPPPMNLPPPLLQRNMAASNIGISHSQRLQTQIASKGHVSMRTKAASLSPAAATHQSQIYGRSQTVAMQGPARTLTMQRGMNMSVNLMPAPAYNVNSVNMNMNTLNAMNGYSMSQPMMNSGYHSNHGYMNQTPQYPMQMQMGMMGSQPYAQQPMQTPPHANMMYTAPGHHGYMNTGMSKQSLNGSYMRR

Q8BRB7-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F8MQ39A0A5F8MQ39_MOUSEKat6b2054
S4R2Q8S4R2Q8_MOUSEKat6b79

Sequence caution

The sequence BAC33305.1 differs from that shown. Reason: Miscellaneous discrepancy Probable intron retention.
The sequence BAC34930.1 differs from that shown. Reason: Miscellaneous discrepancy Probable intron retention.
The sequence BAC38771.1 differs from that shown. Reason: Miscellaneous discrepancy Probable intron retention.

Features

Showing features for alternative sequence, compositional bias, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_014592374-482in isoform 2
Compositional bias846-861Polar residues
Compositional bias885-909Acidic residues
Compositional bias928-943Basic residues
Compositional bias947-961Polar residues
Compositional bias1001-1018Basic and acidic residues
Sequence conflict1033in Ref. 1; AAF26744
Compositional bias1090-1109Basic and acidic residues
Compositional bias1151-1178Acidic residues
Compositional bias1179-1206Basic and acidic residues
Compositional bias1207-1233Acidic residues
Compositional bias1234-1252Basic and acidic residues
Compositional bias1306-1324Basic and acidic residues
Sequence conflict1418in Ref. 1; AAF26744

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF222800
EMBL· GenBank· DDBJ
AAF26744.1
EMBL· GenBank· DDBJ
mRNA
AK045188
EMBL· GenBank· DDBJ
BAC32253.2
EMBL· GenBank· DDBJ
mRNA
AK048336
EMBL· GenBank· DDBJ
BAC33305.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AK052307
EMBL· GenBank· DDBJ
BAC34930.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AK083123
EMBL· GenBank· DDBJ
BAC38771.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AC115122
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC148978
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AY294423
EMBL· GenBank· DDBJ
AAQ01512.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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