Q8BQ93 · Q8BQ93_MOUSE
- ProteinAldehyde dehydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids487 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
Catalytic activity
- (2E)-hexadecenal + NAD+ + H2O = (E)-hexadec-2-enoate + NADH + 2 H+
- hexadecanoate + NADH + 2 H+ = hexadecanal + NAD+ + H2O
- 2,6,10,14-tetramethylpentadecanal + NAD+ + H2O = 2,6,10,14-tetramethylpentadecanoate + NADH + 2 H+
- 22-oxodocosanoate + NAD+ + H2O = docosanedioate + NADH + 2 H+
- octadecanal + NAD+ + H2O = octadecanoate + NADH + 2 H+
- octanal + NAD+ + H2O = octanoate + NADH + 2 H+
- tetradecanal + NAD+ + H2O = tetradecanoate + NADH + 2 H+
- heptanal + NAD+ + H2O = heptanoate + NADH + 2 H+
- a fatty aldehyde + NAD+ + H2O = a fatty acid + NADH + 2 H+
- decanal + NAD+ + H2O = decanoate + NADH + 2 H+
- dodecanoate + NADH + 2 H+ = dodecanal + NAD+ + H2O
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 207 | |||||
Sequence: E | ||||||
Active site | 241 | |||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | aldehyde dehydrogenase (NAD+) activity | |
Biological Process | cellular aldehyde metabolic process | |
Biological Process | fatty acid metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameAldehyde dehydrogenase
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8BQ93
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 464-484 | Helical | ||||
Sequence: LGMLLFVCLVAVAAVIVKFVL |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-421 | Aldehyde dehydrogenase | ||||
Sequence: RQAFRSGRSRPLRFRLQQLEALRRMVQEREKEILAAIAADLSKSELNAYSHEVITILGEIDFMLGNLPELASARPAKKNLLTMMDEAYVQPEPLGVVLIIGAWNYPFVLTMQPLVGAIAAGNAAIVKPSELSENTAKILAELLPQYLDQDLYAIVNGGIPETTELLKQRFDHILYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDRDCDLDVACRRIAWGKYMNCGQACIAPDYILCEASLQNQIVQKIKETVKDFYGENIKASPDYERIINLRHFKRLQSLLKGQKIAFGGEMDEATRYLAPTILTDVDPNSKVMQEEIFGPILPIVSVKNVDEAINFINDREKPLALYVFSRNNKLIKRVIDETSSGGVTGNDVIMHFTVNSLPFGGVGASGMGAYHGKYSFDTFSH |
Sequence similarities
Belongs to the aldehyde dehydrogenase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length487
- Mass (Da)54,300
- Last updated2003-03-01 v1
- ChecksumBF0EE346B26FF6C1