Q8BQ33 · TICRR_MOUSE

  • Protein
    Treslin
  • Gene
    Ticrr
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular Functionchromatin binding
Biological ProcessDNA repair
Biological ProcessDNA replication
Biological Processmitotic DNA replication checkpoint signaling
Biological Processmitotic G2 DNA damage checkpoint signaling
Biological Processregulation of DNA-templated DNA replication initiation
Biological Processresponse to ionizing radiation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Treslin
  • Alternative names
    • TopBP1-interacting checkpoint and replication regulator
    • TopBP1-interacting, replication-stimulating protein

Gene names

    • Name
      Ticrr

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8BQ33
  • Secondary accessions
    • B2RY55
    • Q8C9N4
    • Q8CCI2

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Note: Associates with chromatin.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002966241-1889Treslin
Modified residue295Phosphoserine
Modified residue599Phosphoserine
Modified residue820Phosphoserine
Modified residue861Phosphoserine
Modified residue919Phosphoserine
Modified residue934Phosphoserine
Modified residue1002Phosphoserine
Modified residue1027Phosphoserine
Modified residue1078Phosphoserine
Modified residue1134Phosphothreonine
Modified residue1141Phosphoserine
Modified residue1406Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with TOPBP1 (via BRCT domains); interaction takes place in a CDK2-dependent manner (By similarity).
Component of the replisome complex composed of at least DONSON, MCM2, MCM7, PCNA and TICRR (By similarity).

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region812-836Disordered
Region979-1063Disordered
Compositional bias984-1014Basic and acidic residues
Compositional bias1016-1063Polar residues
Compositional bias1098-1223Polar residues
Region1098-1421Disordered
Compositional bias1254-1282Polar residues
Compositional bias1315-1351Polar residues
Compositional bias1352-1372Pro residues
Compositional bias1399-1421Polar residues
Region1471-1508Disordered
Region1520-1543Disordered
Compositional bias1522-1543Polar residues
Region1629-1714Disordered
Compositional bias1644-1662Polar residues
Region1730-1751Disordered
Compositional bias1737-1751Polar residues
Region1841-1875Disordered

Sequence similarities

Belongs to the treslin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,889
  • Mass (Da)
    208,335
  • Last updated
    2007-07-24 v2
  • Checksum
    EF97B85B7BFD3027
MACCHKVMLLVDTAGVSAPHSPARRAALRLLTYLSCRFGLARVHWTFKFFDSQGARSRPSRVSDFRELGSRSWEDFEEELEARLGDRPPGAHLPGPTPRATHTHGALMETLLDYQWDRPEITSPTKPILRSSGRRLLDADGEAREAQAALGGFGNAVFLLAPCPHSQRELLQFVSGCEAQAQRVPLTPKQVMEKVLPKRVQEVMIARNITLYWVDTTERSKLWASPDHVGYWTVCELLHHGGGTILPAETWSLGFTKARETVLPCGGELSHKPHPSPWISALPIDATVNCLLYNSEYEASFPRIEGTLFLPVQGKEIEETWAISLEPLAMHQRHFQKPVRIVLRGSVAQWSLPVSSALGTDSWMLQSPEEHRSTQRLLFQELVSRLTAEEFHLVASVDPGEGWPPITGIISPFSANAMILTVFRAKEAEFQSHFLQTAATEGSQDTASLFSDVVDSVLNQSHNLFEDPASSAPCVPEWVQQELSHTSSWSPALVEKWFPFSNASGATSDLMESFWLLHAASPDNDESSKTESELTRCLSELYQRSHEESTVVNQERSRKKRGIPRTPVRQKMNTMSRSLKMLNVARLNVKAQKLHPDGSPDTAVEKGLQKAVIGRTADKLEDRGRILRSSKLKEFKTEEELLAYIHDNYQKAVATEEITLYSCAQNMVSTIKMFLKSKDIKELEVACLSHVNSNLLKTSKTLRQNLAGKMDTEDKVGECQLQVFLRLEMCEQCPSVLDRPDEVERIVEEVTDLLRLVCLTKDSAYLSEFLEEILRLYIGSIPGTIGQLYHSLGLKIPQKLAGVLPTGFFSDDSMSQESMSPPPSSSTHRSVSAITESEQLEELRTRSAKKRRKNALIRHKSIAEISQTLRQIEVPKVSKRATRNENSHSASIQLPVPRKDTIQEVTKVRRNLFNQEMLSPSKRGLKKGLPRSHSVSALECLHHKQDKFKKTKSSTFQGYCKLLTKSVAETPVHKQISRRLLHRQIKGRSSDPGPDIHVVEESPEKEDEMTLRRSPRIKQLSFSRTNSGSFYSVSQPKSRSVQRIHSSQQESEQRENFPVQSIQSPKTLLFGALSEIPSSSKKGSAQIKRSLRSMLDSEISTSYETPKKSNQKSPSFSKTTPRRFPRTAQTLLYTPERLQNSPTEMTSAEGTISEATIKTPSSHGYNSPFASKVTSQKTVSPAKEETSPPLTKLPSTPRESDVQPPQCSSDCTWPHSVNSSPEGPYYPASPPPMAGQARSQCLTPIRYSFRTPPRTALAGTSKQQEHQELPLPRASQTQEPPQGLEKKALKIPKKPAHTSTSPLSPEEHYSGCDVSPHQPRNSLSASPPPGELNWKEHQTSPSVTSSVSCPVPSTPPRTPQRMTCPIPPSPPSKLRRSCRKKSCPPQDFPECHPGPSAAPVLSSATSPGAVTGSREEQSQFSEGQSYLGTGFRSDCHVSSPVLTASDTKCLPLIDEAQLHGLKNQEVKSGILPGEEGEEPESTIADELPSVSDPGILVPAPSSVSSSSELLPYPLCCTADGKQRQDAAQQGSPRASEATSSPQTYEVELEMQASGLPKLRIKKIDPGVLLEAEALGKEAPLGEEGALPALCMPKASKSSGRTEHPYLSPPCLRPSHSTPGKNGGQTFICQSCTPSRCPPSTPSPFQADAGVSWTPSPKQSGKTTPEIIKDWPRRKRAVDCSAGPSAGRGEASMDLPGSLSLLEPEPEGKERSLEQDLSKVLISEEFELEGVCQLPDQSPPKDSASVTEETSWGQFGLGRKRFLSAKEESEYKVKRVCDSLSEDPQASKQKECSPRWSALPLHSVGDDEVFVSGSTPPSGCMVRSCLSASGLQALTQSPLLFQGRTPSSHSTDTRDEEVDVFPSTAEESPFSHTLSRKRPFRTYTRKKLIS

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0U1RQ28A0A0U1RQ28_MOUSETicrr409
A0A0U1RNX1A0A0U1RNX1_MOUSETicrr968
Q3UV49Q3UV49_MOUSETicrr718

Sequence caution

The sequence AAH58634.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence BAC28152.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence BAC34701.1 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict7in Ref. 3; BAC31045
Compositional bias984-1014Basic and acidic residues
Compositional bias1016-1063Polar residues
Compositional bias1098-1223Polar residues
Compositional bias1254-1282Polar residues
Compositional bias1315-1351Polar residues
Compositional bias1352-1372Pro residues
Compositional bias1399-1421Polar residues
Sequence conflict1513in Ref. 3; BAC28152
Compositional bias1522-1543Polar residues
Compositional bias1644-1662Polar residues
Compositional bias1737-1751Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC114988
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC158582
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC058634
EMBL· GenBank· DDBJ
AAH58634.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BC158103
EMBL· GenBank· DDBJ
AAI58104.1
EMBL· GenBank· DDBJ
mRNA
AK033104
EMBL· GenBank· DDBJ
BAC28152.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK041726
EMBL· GenBank· DDBJ
BAC31045.1
EMBL· GenBank· DDBJ
mRNA
AK051639
EMBL· GenBank· DDBJ
BAC34701.1
EMBL· GenBank· DDBJ
mRNA Frameshift

Genome annotation databases

Similar Proteins

Disclaimer

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