Q8BPM2 · M4K5_MOUSE
- ProteinMitogen-activated protein kinase kinase kinase kinase 5
- GeneMap4k5
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids847 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (By similarity).
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | MAP kinase kinase kinase kinase activity | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | intracellular signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitogen-activated protein kinase kinase kinase kinase 5
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8BPM2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000086283 | 1-847 | Mitogen-activated protein kinase kinase kinase kinase 5 | |||
Sequence: MEAPLRPAADILRRNPQHDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSEMQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVGQPGLSRALAVELLDKVSNPDNHAPYSEGDEDDLEPHAIIRHTIRSTNRNSRAERTASEINFDKLQFEPPLRKETEARDEMGLSSEPNFILHWNPFVDGANTGRSTSKRAIPPPLPPKPRVNTYPEDSLPDEEKSSTIKRCPDLEARAPQVLRRQSSPSCVPVAETSSSIGNGDGISKLISENTEGSAQAPQLPRKKDKRDFPKPTINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEQAKKPGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGSDSSQVVQFETINLNSASSWFTEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPAAHSNLYILAGHENSY | ||||||
Modified residue | 335 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 433 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 20-277 | Protein kinase | ||||
Sequence: YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSEMQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV | ||||||
Region | 378-487 | Disordered | ||||
Sequence: NTGRSTSKRAIPPPLPPKPRVNTYPEDSLPDEEKSSTIKRCPDLEARAPQVLRRQSSPSCVPVAETSSSIGNGDGISKLISENTEGSAQAPQLPRKKDKRDFPKPTINGL | ||||||
Compositional bias | 402-418 | Basic and acidic residues | ||||
Sequence: PEDSLPDEEKSSTIKRC | ||||||
Compositional bias | 429-467 | Polar residues | ||||
Sequence: LRRQSSPSCVPVAETSSSIGNGDGISKLISENTEGSAQA | ||||||
Domain | 507-820 | CNH | ||||
Sequence: PLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEQAKKPGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGSDSSQVVQFETINLNSASSWFTEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRV |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q8BPM2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length847
- Mass (Da)95,045
- Last updated2003-04-30 v2
- Checksum377F0EFFC6EECFA3
Q8BPM2-2
- Name2
- Differences from canonical
- 294-312: Missing
Features
Showing features for sequence conflict, alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 79 | in Ref. 1; BAC35517 | ||||
Sequence: A → P | ||||||
Sequence conflict | 103 | in Ref. 1; BAC35517 | ||||
Sequence: Q → H | ||||||
Sequence conflict | 118 | in Ref. 1; BAC35517 | ||||
Sequence: A → P | ||||||
Alternative sequence | VSP_050478 | 294-312 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 402-418 | Basic and acidic residues | ||||
Sequence: PEDSLPDEEKSSTIKRC | ||||||
Compositional bias | 429-467 | Polar residues | ||||
Sequence: LRRQSSPSCVPVAETSSSIGNGDGISKLISENTEGSAQA | ||||||
Sequence conflict | 441 | in Ref. 2; AAH40381 | ||||
Sequence: A → V | ||||||
Sequence conflict | 727 | in Ref. 1; BAB31739 | ||||
Sequence: L → Q |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK019468 EMBL· GenBank· DDBJ | BAB31739.1 EMBL· GenBank· DDBJ | mRNA | ||
AK053775 EMBL· GenBank· DDBJ | BAC35517.1 EMBL· GenBank· DDBJ | mRNA | ||
AK084891 EMBL· GenBank· DDBJ | BAC39305.1 EMBL· GenBank· DDBJ | mRNA | ||
BC002309 EMBL· GenBank· DDBJ | AAH02309.1 EMBL· GenBank· DDBJ | mRNA | ||
BC040381 EMBL· GenBank· DDBJ | AAH40381.2 EMBL· GenBank· DDBJ | mRNA | ||
BC057930 EMBL· GenBank· DDBJ | AAH57930.1 EMBL· GenBank· DDBJ | mRNA |