Significant sex differences were observed with Adnp(+/-) males being more susceptible to stress in the object and social recognition tests and the females more susceptible in the open field and elevated plus maze tests.
Sonography and immunofluorescence staining of epidermal layers revealed that the dermis was thinner in the patient than in a healthy control. Adnp haploinsufficient mice (Adnp(+/-)) mimicked the human condition showing reduced dermal thickness.
The Adnp haploinsufficient mouse mimics the human ADNP syndrome in terms of synapse density and gene expression patterns as well as in developmental motor and cognitive abilities.
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