Q8BNS7 · Q8BNS7_MOUSE
- ProteinCollagen IV NC1 domain-containing protein
- GeneCol4a5
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids799 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Publications for Q8BNS7
Encyclopedia of the mouse genome III. October 1993. Mouse X chromosome.
- CategorySequences
- SourceMGI: 88456
Aberrant differentiation of neuromuscular junctions in mice lacking s- laminin/laminin beta 2.
- CategoryFunction
- SourceMGI: 88456
Loss of the collagen IV modifier prolyl 3-hydroxylase 2 causes thin basement membrane nephropathy.
- CategoriesFunction, Expression
- SourceMGI: 88456
Intravital imaging reveals glomerular capillary distension and endothelial and immune cell activation early in Alport syndrome.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 88456
Identification of an Altered Matrix Signature in Kidney Aging and Disease.
- CategoryFunction
- SourceMGI: 88456
Bidirectional, non-necrotizing glomerular crescents are the critical pathology in X-linked Alport syndrome mouse model harboring nonsense mutation of human COL4A5.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 88456
Glomerular endothelial cell heterogeneity in Alport syndrome.
- CategoryFunction
- SourceMGI: 88456
Development of an exon skipping therapy for X-linked Alport syndrome with truncating variants in COL4A5.
- AnnotationDevelopment of an exon skipping therapy for X-linked Alport syndrome with truncating variants in COL4A5.
- CategoryPhenotypes & Variants
Modification of an aggressive model of Alport Syndrome reveals early differences in disease pathogenesis due to genetic background.
- CategoryPhenotypes & Variants
- SourceMGI: 88456
Establishment of X-linked Alport syndrome model mice with a <i>Col4a5</i> R471X mutation.
- CategoryPhenotypes & Variants
- SourceMGI: 88456
Type IV collagen alpha6 chain is a regulator of keratin 10 in keratinization of oral mucosal epithelium.
- CategoriesFunction, Expression
- SourceMGI: 88456
Pathogenicity of a Human Laminin pii>betapi/i>2 Mutation Revealed in Models of Alport Syndrome.
- CategoriesSequences, Phenotypes & Variants
- SourceMGI: 88456
Amniotic fluid stem cell-derived vesicles protect from VEGF-induced endothelial damage.
- CategoryFunction
- SourceMGI: 88456
STAT3 inhibition attenuates the progressive phenotypes of Alport syndrome mouse model.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 88456
A step towards clinical application of acellular matrix: A clue from macrophage polarization.
- CategoryFunction
- SourceMGI: 88456
A potential target gene for the host-directed therapy of mycobacterial infection in murine macrophages.
- AnnotationFindings indicate a role for collagen alpha-5(IV) chain (Col4a5) in the regulation of macrophage responses to mycobacterial infection and identify Col4a5 as a potential target for the host-directed anti-mycobacterial therapy.
- CategorySequences
- SourceGeneRif: 12830
COL4A6 is dispensable for autosomal recessive Alport syndrome.
- Annotationalthough alpha5 and alpha6 (IV) chains are induced in the glomerular basement membrane in autosomal recessive Alport syndrome their induction does not seem to play a major compensatory role
- CategoriesFunction, Sequences
Minor Type IV Collagen alpha5 Chain Promotes Cancer Progression through Discoidin Domain Receptor-1.
- Annotationalpha5(IV) but not alpha1(IV) promotes lung cancer cell proliferation and tumor angiogenesis through non-integrin collagen receptor DDR1-mediated ERK activation.
- CategoriesFunction, Phenotypes & Variants
A mouse Col4a4 mutation causing Alport glomerulosclerosis with abnormal collagen alpha3alpha4alpha5(IV) trimers.
- AnnotationReport novel mouse model of Alport syndrome with accumulation abnormal collagen alpha3alpha4alpha5(IV) trimers in the glomerular basement membrane.
- CategorySequences
Mechanical response of wild-type and Alport murine lens capsules during osmotic swelling.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 88456